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Antioxidant and hepatoprotective activity of ethanol extract of Arachniodes exilis (Hance) Ching.
J Ethnopharmacol. 2010 May 27; 129(2):232-7.JE

Abstract

AIM OF THE STUDY

The study was aimed to investigate the ethanol extract of Arachniodes exilis for the antioxidant and hepatoprotective activity.

MATERIALS AND METHODS

Antioxidant activity was evaluated by different assays, including reducing power, lipid peroxidation, 2, 2'-diphenyl-1-picrylhydrazyl (DPPH), 2, 2'-azinobis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS), superoxide anion, hydroxyl radicals and hydrogen peroxide. The hepatoprotective activity of ethanol extract was studied on mice liver damage induced by CCL(4) by monitoring biochemical parameters.

RESULTS

The extract showed potent activities on reducing power, lipid peroxide, DPPH, ABTS, superoxide anion, hydroxyl radical and hydrogen peroxide. And oral administration of Arachniodes exilis at different doses resulted in significant improvement on the levels of glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, malondialchehyche and superoxidedismutase.

CONCLUSION

The results indicate that this plant possesses potential antioxidant and hepatoprotective properties and has therapeutic potential for the treatment of liver diseases.

Authors+Show Affiliations

Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation of Hubei Province, College of Pharmacy, Huazhong University of Science and Technology, Wuhan, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20347029

Citation

Zhou, Daonian, et al. "Antioxidant and Hepatoprotective Activity of Ethanol Extract of Arachniodes Exilis (Hance) Ching." Journal of Ethnopharmacology, vol. 129, no. 2, 2010, pp. 232-7.
Zhou D, Ruan J, Cai Y, et al. Antioxidant and hepatoprotective activity of ethanol extract of Arachniodes exilis (Hance) Ching. J Ethnopharmacol. 2010;129(2):232-7.
Zhou, D., Ruan, J., Cai, Y., Xiong, Z., Fu, W., & Wei, A. (2010). Antioxidant and hepatoprotective activity of ethanol extract of Arachniodes exilis (Hance) Ching. Journal of Ethnopharmacology, 129(2), 232-7. https://doi.org/10.1016/j.jep.2010.03.016
Zhou D, et al. Antioxidant and Hepatoprotective Activity of Ethanol Extract of Arachniodes Exilis (Hance) Ching. J Ethnopharmacol. 2010 May 27;129(2):232-7. PubMed PMID: 20347029.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant and hepatoprotective activity of ethanol extract of Arachniodes exilis (Hance) Ching. AU - Zhou,Daonian, AU - Ruan,Jinlan, AU - Cai,Yaling, AU - Xiong,Zhaomei, AU - Fu,Wei, AU - Wei,Anhua, Y1 - 2010/03/25/ PY - 2009/03/11/received PY - 2010/01/13/revised PY - 2010/03/17/accepted PY - 2010/3/30/entrez PY - 2010/3/30/pubmed PY - 2010/10/29/medline SP - 232 EP - 7 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 129 IS - 2 N2 - AIM OF THE STUDY: The study was aimed to investigate the ethanol extract of Arachniodes exilis for the antioxidant and hepatoprotective activity. MATERIALS AND METHODS: Antioxidant activity was evaluated by different assays, including reducing power, lipid peroxidation, 2, 2'-diphenyl-1-picrylhydrazyl (DPPH), 2, 2'-azinobis-3-ethylbenzothiazoline-6-sulphonic acid (ABTS), superoxide anion, hydroxyl radicals and hydrogen peroxide. The hepatoprotective activity of ethanol extract was studied on mice liver damage induced by CCL(4) by monitoring biochemical parameters. RESULTS: The extract showed potent activities on reducing power, lipid peroxide, DPPH, ABTS, superoxide anion, hydroxyl radical and hydrogen peroxide. And oral administration of Arachniodes exilis at different doses resulted in significant improvement on the levels of glutamate oxaloacetate transaminase, glutamate pyruvate transaminase, malondialchehyche and superoxidedismutase. CONCLUSION: The results indicate that this plant possesses potential antioxidant and hepatoprotective properties and has therapeutic potential for the treatment of liver diseases. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/20347029/Antioxidant_and_hepatoprotective_activity_of_ethanol_extract_of_Arachniodes_exilis__Hance__Ching_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(10)00178-9 DB - PRIME DP - Unbound Medicine ER -