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Case-control study of risk of Parkinson's disease in relation to hypertension, hypercholesterolemia, and diabetes in Japan.
J Neurol Sci 2010; 293(1-2):82-6JN

Abstract

This case-control study investigated the associations of a history of hypertension, hypercholesterolemia, and diabetes mellitus with the risk of Parkinson's disease (PD) in Japan. Included were 249 cases within 6 years of onset of PD. Controls were 368 inpatients and outpatients without a neurodegenerative disease. Data on the vascular risk factors and confounders were obtained from a self-administered questionnaire. The vascular risk factors were defined based on drug treatment. Adjustment was made for sex, age, region of residence, pack-years of smoking, years of education, leisure-time exercise, body mass index, dietary intake of energy, cholesterol, vitamin E, alcohol, and coffee and the dietary glycemic index. The proportions of hypertension, hypercholesterolemia, and diabetes mellitus prior to the onset of PD were 23.7%, 9.6%, and 4.0%, respectively, in cases. Hypertension, hypercholesterolemia, and diabetes mellitus were significantly associated with a decreased risk of PD: the adjusted ORs were 0.43 (95% CI: 0.29-0.64), 0.58 (95% CI: 0.33-0.97), and 0.38 (95% CI: 0.17-0.79), respectively. No significant differences were observed in the association of vascular risk factors with the risk of PD between men and women. We found evidence of significant inverse associations of hypertension, hypercholesterolemia, and diabetes mellitus with the risk of PD in Japan. Further well-designed investigations of the association of vascular risk factors with the risk of PD are needed, particularly large-scale prospective studies in Asia.

Authors+Show Affiliations

Department of Public Health, Faculty of Medicine, Fukuoka University, Jonan-ku, Fukuoka, Japan. miyake-y@fukuoka-u.ac.jpNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20347450

Citation

Miyake, Yoshihiro, et al. "Case-control Study of Risk of Parkinson's Disease in Relation to Hypertension, Hypercholesterolemia, and Diabetes in Japan." Journal of the Neurological Sciences, vol. 293, no. 1-2, 2010, pp. 82-6.
Miyake Y, Tanaka K, Fukushima W, et al. Case-control study of risk of Parkinson's disease in relation to hypertension, hypercholesterolemia, and diabetes in Japan. J Neurol Sci. 2010;293(1-2):82-6.
Miyake, Y., Tanaka, K., Fukushima, W., Sasaki, S., Kiyohara, C., Tsuboi, Y., ... Nagai, M. (2010). Case-control study of risk of Parkinson's disease in relation to hypertension, hypercholesterolemia, and diabetes in Japan. Journal of the Neurological Sciences, 293(1-2), pp. 82-6. doi:10.1016/j.jns.2010.03.002.
Miyake Y, et al. Case-control Study of Risk of Parkinson's Disease in Relation to Hypertension, Hypercholesterolemia, and Diabetes in Japan. J Neurol Sci. 2010 Jun 15;293(1-2):82-6. PubMed PMID: 20347450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Case-control study of risk of Parkinson's disease in relation to hypertension, hypercholesterolemia, and diabetes in Japan. AU - Miyake,Yoshihiro, AU - Tanaka,Keiko, AU - Fukushima,Wakaba, AU - Sasaki,Satoshi, AU - Kiyohara,Chikako, AU - Tsuboi,Yoshio, AU - Yamada,Tatsuo, AU - Oeda,Tomoko, AU - Miki,Takami, AU - Kawamura,Nobutoshi, AU - Sakae,Nobutaka, AU - Fukuyama,Hidenao, AU - Hirota,Yoshio, AU - Nagai,Masaki, AU - ,, Y1 - 2010/03/29/ PY - 2010/01/15/received PY - 2010/03/01/revised PY - 2010/03/05/accepted PY - 2010/3/30/entrez PY - 2010/3/30/pubmed PY - 2010/8/13/medline SP - 82 EP - 6 JF - Journal of the neurological sciences JO - J. Neurol. Sci. VL - 293 IS - 1-2 N2 - This case-control study investigated the associations of a history of hypertension, hypercholesterolemia, and diabetes mellitus with the risk of Parkinson's disease (PD) in Japan. Included were 249 cases within 6 years of onset of PD. Controls were 368 inpatients and outpatients without a neurodegenerative disease. Data on the vascular risk factors and confounders were obtained from a self-administered questionnaire. The vascular risk factors were defined based on drug treatment. Adjustment was made for sex, age, region of residence, pack-years of smoking, years of education, leisure-time exercise, body mass index, dietary intake of energy, cholesterol, vitamin E, alcohol, and coffee and the dietary glycemic index. The proportions of hypertension, hypercholesterolemia, and diabetes mellitus prior to the onset of PD were 23.7%, 9.6%, and 4.0%, respectively, in cases. Hypertension, hypercholesterolemia, and diabetes mellitus were significantly associated with a decreased risk of PD: the adjusted ORs were 0.43 (95% CI: 0.29-0.64), 0.58 (95% CI: 0.33-0.97), and 0.38 (95% CI: 0.17-0.79), respectively. No significant differences were observed in the association of vascular risk factors with the risk of PD between men and women. We found evidence of significant inverse associations of hypertension, hypercholesterolemia, and diabetes mellitus with the risk of PD in Japan. Further well-designed investigations of the association of vascular risk factors with the risk of PD are needed, particularly large-scale prospective studies in Asia. SN - 1878-5883 UR - https://www.unboundmedicine.com/medline/citation/20347450/Case_control_study_of_risk_of_Parkinson's_disease_in_relation_to_hypertension_hypercholesterolemia_and_diabetes_in_Japan_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(10)00105-X DB - PRIME DP - Unbound Medicine ER -