Tags

Type your tag names separated by a space and hit enter

The role of essential metals in the placental transfer of lead from mother to child.
Reprod Toxicol. 2010 Jul; 29(4):443-6.RT

Abstract

Epidemiological studies have found adverse birth and child health outcomes from prenatal lead exposure, but little is known about factors influencing placental transfer. In this study we describe the placental transfer of lead in a Taiwanese population, and investigate whether three essential metals - zinc, manganese, or selenium - influence transfer. Maternal and cord blood samples (308 pairs) from a birth cohort study were analyzed using multiple linear regression. There was a clear correlation between mother and child lead concentration (r=0.48, p<0.001), although lead concentration in cord blood (mean=1.29, SD=0.72 microg/dL) was lower than that for mothers (mean=1.58, SD=1.11 microg/dL). Cord blood lead was lower where the mother had a higher blood concentration of zinc (p<0.001) or manganese (p=0.02). Thus maternal blood zinc and manganese, but not selenium, appeared to decrease the placental transfer of lead. These findings raise the possibility of reducing placental transfer of lead by increasing zinc levels via nutritional supplementation during pregnancy.

Authors+Show Affiliations

Department of Epidemiology and Population Health, London School of Hygiene and Tropical Medicine, Keppel Street, London WC1E 7HT, United Kingdom.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20347956

Citation

Lin, Chien-Mu, et al. "The Role of Essential Metals in the Placental Transfer of Lead From Mother to Child." Reproductive Toxicology (Elmsford, N.Y.), vol. 29, no. 4, 2010, pp. 443-6.
Lin CM, Doyle P, Wang D, et al. The role of essential metals in the placental transfer of lead from mother to child. Reprod Toxicol. 2010;29(4):443-6.
Lin, C. M., Doyle, P., Wang, D., Hwang, Y. H., & Chen, P. C. (2010). The role of essential metals in the placental transfer of lead from mother to child. Reproductive Toxicology (Elmsford, N.Y.), 29(4), 443-6. https://doi.org/10.1016/j.reprotox.2010.03.004
Lin CM, et al. The Role of Essential Metals in the Placental Transfer of Lead From Mother to Child. Reprod Toxicol. 2010;29(4):443-6. PubMed PMID: 20347956.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The role of essential metals in the placental transfer of lead from mother to child. AU - Lin,Chien-Mu, AU - Doyle,Pat, AU - Wang,Duolao, AU - Hwang,Yaw-Huei, AU - Chen,Pau-Chung, Y1 - 2010/03/27/ PY - 2009/10/29/received PY - 2010/02/27/revised PY - 2010/03/21/accepted PY - 2010/3/30/entrez PY - 2010/3/30/pubmed PY - 2010/9/23/medline SP - 443 EP - 6 JF - Reproductive toxicology (Elmsford, N.Y.) JO - Reprod Toxicol VL - 29 IS - 4 N2 - Epidemiological studies have found adverse birth and child health outcomes from prenatal lead exposure, but little is known about factors influencing placental transfer. In this study we describe the placental transfer of lead in a Taiwanese population, and investigate whether three essential metals - zinc, manganese, or selenium - influence transfer. Maternal and cord blood samples (308 pairs) from a birth cohort study were analyzed using multiple linear regression. There was a clear correlation between mother and child lead concentration (r=0.48, p<0.001), although lead concentration in cord blood (mean=1.29, SD=0.72 microg/dL) was lower than that for mothers (mean=1.58, SD=1.11 microg/dL). Cord blood lead was lower where the mother had a higher blood concentration of zinc (p<0.001) or manganese (p=0.02). Thus maternal blood zinc and manganese, but not selenium, appeared to decrease the placental transfer of lead. These findings raise the possibility of reducing placental transfer of lead by increasing zinc levels via nutritional supplementation during pregnancy. SN - 1873-1708 UR - https://www.unboundmedicine.com/medline/citation/20347956/The_role_of_essential_metals_in_the_placental_transfer_of_lead_from_mother_to_child_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0890-6238(10)00046-8 DB - PRIME DP - Unbound Medicine ER -