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Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses.
Nat Neurosci. 2010 May; 13(5):592-600.NN

Abstract

When chronic alterations in neuronal activity occur, network gain is maintained by global homeostatic scaling of synaptic strength, but the stability of microcircuits can be controlled by unique adaptations that differ from the global changes. It is not understood how specificity of synaptic tuning is achieved. We found that, although a large population of inhibitory synapses was homeostatically scaled down after chronic inactivity, decreased endocannabinoid tone specifically strengthened a subset of GABAergic synapses that express cannabinoid receptors. In rat hippocampal slice cultures, a 3-5-d blockade of neuronal firing facilitated uptake and degradation of anandamide. The consequent reduction in basal stimulation of cannabinoid receptors augmented GABA release probability, fostering rapid depression of synaptic inhibition and on-demand disinhibition. This regulatory mechanism, mediated by activity-dependent changes in tonic endocannabinoid level, permits selective local tuning of inhibitory synapses in hippocampal networks.

Authors+Show Affiliations

Departments of Physiology, University of Maryland School of Medicine, Baltimore, Maryland, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20348918

Citation

Kim, Jimok, and Bradley E. Alger. "Reduction in Endocannabinoid Tone Is a Homeostatic Mechanism for Specific Inhibitory Synapses." Nature Neuroscience, vol. 13, no. 5, 2010, pp. 592-600.
Kim J, Alger BE. Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses. Nat Neurosci. 2010;13(5):592-600.
Kim, J., & Alger, B. E. (2010). Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses. Nature Neuroscience, 13(5), 592-600. https://doi.org/10.1038/nn.2517
Kim J, Alger BE. Reduction in Endocannabinoid Tone Is a Homeostatic Mechanism for Specific Inhibitory Synapses. Nat Neurosci. 2010;13(5):592-600. PubMed PMID: 20348918.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Reduction in endocannabinoid tone is a homeostatic mechanism for specific inhibitory synapses. AU - Kim,Jimok, AU - Alger,Bradley E, Y1 - 2010/03/28/ PY - 2009/12/24/received PY - 2010/02/16/accepted PY - 2010/3/30/entrez PY - 2010/3/30/pubmed PY - 2010/5/8/medline SP - 592 EP - 600 JF - Nature neuroscience JO - Nat Neurosci VL - 13 IS - 5 N2 - When chronic alterations in neuronal activity occur, network gain is maintained by global homeostatic scaling of synaptic strength, but the stability of microcircuits can be controlled by unique adaptations that differ from the global changes. It is not understood how specificity of synaptic tuning is achieved. We found that, although a large population of inhibitory synapses was homeostatically scaled down after chronic inactivity, decreased endocannabinoid tone specifically strengthened a subset of GABAergic synapses that express cannabinoid receptors. In rat hippocampal slice cultures, a 3-5-d blockade of neuronal firing facilitated uptake and degradation of anandamide. The consequent reduction in basal stimulation of cannabinoid receptors augmented GABA release probability, fostering rapid depression of synaptic inhibition and on-demand disinhibition. This regulatory mechanism, mediated by activity-dependent changes in tonic endocannabinoid level, permits selective local tuning of inhibitory synapses in hippocampal networks. SN - 1546-1726 UR - https://www.unboundmedicine.com/medline/citation/20348918/Reduction_in_endocannabinoid_tone_is_a_homeostatic_mechanism_for_specific_inhibitory_synapses_ L2 - https://doi.org/10.1038/nn.2517 DB - PRIME DP - Unbound Medicine ER -