Tags

Type your tag names separated by a space and hit enter

Risk of pancreatic cancer by alcohol dose, duration, and pattern of consumption, including binge drinking: a population-based study.

Abstract

Alcohol consumption is postulated to be a risk factor for pancreatic cancer (PCA), but clarification of degree of risk related to consumption characteristics is lacking. We examined the association between alcohol consumption and PCA in a population-based case-control study (532 cases, 1,701 controls) in the San Francisco Bay Area. Population-based controls were frequency-matched by sex, age within 5-year categories and county of residence to cases identified by the cancer registry's rapid case ascertainment. Detailed alcohol consumption data, including binge drinking (>or=5 drinks/day), were collected during in-person interviews. Odds ratios (OR) and 95% confidence intervals (95% CI) were computed using adjusted unconditional logistic regression. Depending on dose, duration, and pattern of drinking, ORs were increased 1.5- to 6-fold among men but not women. In men, ORs increased with increasing overall alcohol consumption (22-35 drinks/week OR = 2.2, 95% CI = 1.1-4.0; >or=35 drinks/week OR = 2.6, 95% CI = 1.3-5.1, p-trend = 0.04). Most notable were effects with a history of binge drinking (OR = 3.5, 95% CI = 1.6-7.5) including increased number of drinks per day (p-trend = 0.002), and increased years of binge drinking (p-trend = 0.0006). In fully adjusted models that included smoking and other confounders, ORs for binge drinking in men were somewhat higher than in age-adjusted models. Results from our detailed analyses provide support for heavy alcohol consumption (including binge drinking) as a risk factor for PCA in men.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    Division of Digestive and Liver Diseases, Harold C Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas, TX 75390-8887, USA. samir.gupta@utsouthwestern.edu

    , ,

    Source

    Cancer causes & control : CCC 21:7 2010 Jul pg 1047-59

    MeSH

    Adult
    Aged
    Aged, 80 and over
    Alcohol Drinking
    Case-Control Studies
    Central Nervous System Depressants
    Ethanol
    Female
    Humans
    Logistic Models
    Male
    Middle Aged
    Multivariate Analysis
    Odds Ratio
    Pancreatic Neoplasms
    Population Surveillance
    Risk Assessment
    Risk Factors
    San Francisco
    Sex Factors
    Smoking
    Young Adult

    Pub Type(s)

    Journal Article
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    20349126

    Citation

    Gupta, Samir, et al. "Risk of Pancreatic Cancer By Alcohol Dose, Duration, and Pattern of Consumption, Including Binge Drinking: a Population-based Study." Cancer Causes & Control : CCC, vol. 21, no. 7, 2010, pp. 1047-59.
    Gupta S, Wang F, Holly EA, et al. Risk of pancreatic cancer by alcohol dose, duration, and pattern of consumption, including binge drinking: a population-based study. Cancer Causes Control. 2010;21(7):1047-59.
    Gupta, S., Wang, F., Holly, E. A., & Bracci, P. M. (2010). Risk of pancreatic cancer by alcohol dose, duration, and pattern of consumption, including binge drinking: a population-based study. Cancer Causes & Control : CCC, 21(7), pp. 1047-59. doi:10.1007/s10552-010-9533-6.
    Gupta S, et al. Risk of Pancreatic Cancer By Alcohol Dose, Duration, and Pattern of Consumption, Including Binge Drinking: a Population-based Study. Cancer Causes Control. 2010;21(7):1047-59. PubMed PMID: 20349126.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Risk of pancreatic cancer by alcohol dose, duration, and pattern of consumption, including binge drinking: a population-based study. AU - Gupta,Samir, AU - Wang,Furong, AU - Holly,Elizabeth A, AU - Bracci,Paige M, Y1 - 2010/03/27/ PY - 2009/11/16/received PY - 2010/03/04/accepted PY - 2010/3/30/entrez PY - 2010/3/30/pubmed PY - 2010/9/16/medline SP - 1047 EP - 59 JF - Cancer causes & control : CCC JO - Cancer Causes Control VL - 21 IS - 7 N2 - Alcohol consumption is postulated to be a risk factor for pancreatic cancer (PCA), but clarification of degree of risk related to consumption characteristics is lacking. We examined the association between alcohol consumption and PCA in a population-based case-control study (532 cases, 1,701 controls) in the San Francisco Bay Area. Population-based controls were frequency-matched by sex, age within 5-year categories and county of residence to cases identified by the cancer registry's rapid case ascertainment. Detailed alcohol consumption data, including binge drinking (>or=5 drinks/day), were collected during in-person interviews. Odds ratios (OR) and 95% confidence intervals (95% CI) were computed using adjusted unconditional logistic regression. Depending on dose, duration, and pattern of drinking, ORs were increased 1.5- to 6-fold among men but not women. In men, ORs increased with increasing overall alcohol consumption (22-35 drinks/week OR = 2.2, 95% CI = 1.1-4.0; >or=35 drinks/week OR = 2.6, 95% CI = 1.3-5.1, p-trend = 0.04). Most notable were effects with a history of binge drinking (OR = 3.5, 95% CI = 1.6-7.5) including increased number of drinks per day (p-trend = 0.002), and increased years of binge drinking (p-trend = 0.0006). In fully adjusted models that included smoking and other confounders, ORs for binge drinking in men were somewhat higher than in age-adjusted models. Results from our detailed analyses provide support for heavy alcohol consumption (including binge drinking) as a risk factor for PCA in men. SN - 1573-7225 UR - https://www.unboundmedicine.com/medline/citation/20349126/full_citation L2 - https://doi.org/10.1007/s10552-010-9533-6 DB - PRIME DP - Unbound Medicine ER -