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Tailoring of locust bean gum and development of hydrogel beads for controlled oral delivery of glipizide.
Drug Deliv. 2010 Jul; 17(5):288-300.DD

Abstract

In this study, carboxymethyl derivative of locust bean gum was prepared, characterized, and its gelling ability with different concentrations (1-5% w/v) of aluminum chloride (AlCl(3)) was utilized for the development of glipizide-loaded beads in a completely aqueous environment. The beads were spherical when observed under a scanning electron microscope. Increase in gelling ion concentration decreased the drug entrapment efficiency from 97.68% to 95.14%. The beads swelled more slowly in pH 1.2 KCl-HCl buffer and exhibited a slower drug release pattern than that observed in pH 7.4 phosphate buffer. Irrespective of the dissolution media, the drug release became slower at higher AlCl(3) concentration. The drug release in alkaline medium was found to be controlled by a combination of diffusion as well as polymer relaxation phenomena. Comparing the release profiles, it was observed that the beads treated with 5% AlCl(3) provided slower drug release up to 10 h in alkaline medium without any sign of disintegration and, thus, this formulation was selected for further studies. Fourier transform infrared (FTIR) spectroscopy indicated the stable nature of the drug in the beads. Differential scanning calorimetry and X-ray diffraction analysis showed that most of the drug remained in amorphous state in the beads. Stability study indicated no statistical significant difference in drug entrapment efficiency of the beads. In vivo activity of the beads was tested and a prolonged hypoglycemic effect was achieved. Hence, carboxymethyl locust bean beads could be a potential carrier for controlled oral delivery of glipizide.

Authors+Show Affiliations

Gupta College of Technological Sciences, Ashram More, G.T Road, Asansol-713301, West Bengal, India. sabya245@rediffmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20350054

Citation

Maiti, Sabyasachi, et al. "Tailoring of Locust Bean Gum and Development of Hydrogel Beads for Controlled Oral Delivery of Glipizide." Drug Delivery, vol. 17, no. 5, 2010, pp. 288-300.
Maiti S, Dey P, Banik A, et al. Tailoring of locust bean gum and development of hydrogel beads for controlled oral delivery of glipizide. Drug Deliv. 2010;17(5):288-300.
Maiti, S., Dey, P., Banik, A., Sa, B., Ray, S., & Kaity, S. (2010). Tailoring of locust bean gum and development of hydrogel beads for controlled oral delivery of glipizide. Drug Delivery, 17(5), 288-300. https://doi.org/10.3109/10717541003706265
Maiti S, et al. Tailoring of Locust Bean Gum and Development of Hydrogel Beads for Controlled Oral Delivery of Glipizide. Drug Deliv. 2010;17(5):288-300. PubMed PMID: 20350054.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Tailoring of locust bean gum and development of hydrogel beads for controlled oral delivery of glipizide. AU - Maiti,Sabyasachi, AU - Dey,Paramita, AU - Banik,Arunava, AU - Sa,Biswanath, AU - Ray,Somasree, AU - Kaity,Santanu, PY - 2010/3/31/entrez PY - 2010/3/31/pubmed PY - 2010/9/3/medline SP - 288 EP - 300 JF - Drug delivery JO - Drug Deliv VL - 17 IS - 5 N2 - In this study, carboxymethyl derivative of locust bean gum was prepared, characterized, and its gelling ability with different concentrations (1-5% w/v) of aluminum chloride (AlCl(3)) was utilized for the development of glipizide-loaded beads in a completely aqueous environment. The beads were spherical when observed under a scanning electron microscope. Increase in gelling ion concentration decreased the drug entrapment efficiency from 97.68% to 95.14%. The beads swelled more slowly in pH 1.2 KCl-HCl buffer and exhibited a slower drug release pattern than that observed in pH 7.4 phosphate buffer. Irrespective of the dissolution media, the drug release became slower at higher AlCl(3) concentration. The drug release in alkaline medium was found to be controlled by a combination of diffusion as well as polymer relaxation phenomena. Comparing the release profiles, it was observed that the beads treated with 5% AlCl(3) provided slower drug release up to 10 h in alkaline medium without any sign of disintegration and, thus, this formulation was selected for further studies. Fourier transform infrared (FTIR) spectroscopy indicated the stable nature of the drug in the beads. Differential scanning calorimetry and X-ray diffraction analysis showed that most of the drug remained in amorphous state in the beads. Stability study indicated no statistical significant difference in drug entrapment efficiency of the beads. In vivo activity of the beads was tested and a prolonged hypoglycemic effect was achieved. Hence, carboxymethyl locust bean beads could be a potential carrier for controlled oral delivery of glipizide. SN - 1521-0464 UR - https://www.unboundmedicine.com/medline/citation/20350054/Tailoring_of_locust_bean_gum_and_development_of_hydrogel_beads_for_controlled_oral_delivery_of_glipizide_ L2 - https://www.tandfonline.com/doi/full/10.3109/10717541003706265 DB - PRIME DP - Unbound Medicine ER -