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Effect of alpha-tocopherol and beta-carotene supplementation on macrovascular complications and total mortality from diabetes: results of the ATBC Study.

Abstract

AIM

To determine whether alpha-tocopherol or beta-carotene supplementation affects diabetic macrovascular complications and total mortality.

METHODS

This study was carried out as part of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, a double-blind, randomized trial with a 2x2 factorial design. A total of 29,133 middle-aged male smokers received either vitamin E 50 mg/day or beta-carotene 20 mg/day, or both, or placebo for a median of 6.1 years. At base-line, 1700 men had type 2 diabetes. Of these men, 662 were diagnosed with first-ever macrovascular complication, and 1142 died during the 19-year follow-up.

RESULTS

Neither supplementation affected the risk of macrovascular complication or total mortality during the intervention period. For the alpha-tocopherol-supplemented versus no alpha-tocopherol-supplemented, and beta-carotene-supplemented versus no beta-carotene-supplemented we found relative risk (RR) 0.84 (95% confidence interval (CI) 0.65-1.10) and RR 1.15 (95% CI 0.89-1.50) for macrovascular complication, respectively, and RR 1.00 (95% CI 0.80-1.25) and RR 1.06 (95% CI 0.85-1.33) for total mortality, respectively. No essential changes were found in these effects when the follow-up was extended up to 19 years.

CONCLUSION

Alpha-tocopherol or beta-carotene supplementation has no protective effect on macrovascular outcomes or total mortality of diabetic male smokers.

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  • Publisher Full Text
  • Authors+Show Affiliations

    ,

    National Institute for Health and Welfare, Mannerheimintie 166, Helsinki, Finland. merja.kataja-tuomola@thl.fi

    , , ,

    Source

    Annals of medicine 42:3 2010 Apr pg 178-86

    MeSH

    Aged
    Coronary Disease
    Diabetes Mellitus
    Diabetic Angiopathies
    Double-Blind Method
    Finland
    Humans
    Male
    Middle Aged
    Peripheral Vascular Diseases
    Smoking
    Stroke
    Survival Rate
    Treatment Outcome
    Vitamins
    alpha-Tocopherol
    beta Carotene

    Pub Type(s)

    Journal Article
    Randomized Controlled Trial
    Research Support, N.I.H., Extramural

    Language

    eng

    PubMed ID

    20350251

    Citation

    Kataja-Tuomola, Merja K., et al. "Effect of Alpha-tocopherol and Beta-carotene Supplementation On Macrovascular Complications and Total Mortality From Diabetes: Results of the ATBC Study." Annals of Medicine, vol. 42, no. 3, 2010, pp. 178-86.
    Kataja-Tuomola MK, Kontto JP, Männistö S, et al. Effect of alpha-tocopherol and beta-carotene supplementation on macrovascular complications and total mortality from diabetes: results of the ATBC Study. Ann Med. 2010;42(3):178-86.
    Kataja-Tuomola, M. K., Kontto, J. P., Männistö, S., Albanes, D., & Virtamo, J. R. (2010). Effect of alpha-tocopherol and beta-carotene supplementation on macrovascular complications and total mortality from diabetes: results of the ATBC Study. Annals of Medicine, 42(3), pp. 178-86. doi:10.3109/07853890903508887.
    Kataja-Tuomola MK, et al. Effect of Alpha-tocopherol and Beta-carotene Supplementation On Macrovascular Complications and Total Mortality From Diabetes: Results of the ATBC Study. Ann Med. 2010;42(3):178-86. PubMed PMID: 20350251.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Effect of alpha-tocopherol and beta-carotene supplementation on macrovascular complications and total mortality from diabetes: results of the ATBC Study. AU - Kataja-Tuomola,Merja K, AU - Kontto,Jukka P, AU - Männistö,Satu, AU - Albanes,Demetrius, AU - Virtamo,Jarmo R, PY - 2010/3/31/entrez PY - 2010/3/31/pubmed PY - 2010/6/19/medline SP - 178 EP - 86 JF - Annals of medicine JO - Ann. Med. VL - 42 IS - 3 N2 - AIM: To determine whether alpha-tocopherol or beta-carotene supplementation affects diabetic macrovascular complications and total mortality. METHODS: This study was carried out as part of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, a double-blind, randomized trial with a 2x2 factorial design. A total of 29,133 middle-aged male smokers received either vitamin E 50 mg/day or beta-carotene 20 mg/day, or both, or placebo for a median of 6.1 years. At base-line, 1700 men had type 2 diabetes. Of these men, 662 were diagnosed with first-ever macrovascular complication, and 1142 died during the 19-year follow-up. RESULTS: Neither supplementation affected the risk of macrovascular complication or total mortality during the intervention period. For the alpha-tocopherol-supplemented versus no alpha-tocopherol-supplemented, and beta-carotene-supplemented versus no beta-carotene-supplemented we found relative risk (RR) 0.84 (95% confidence interval (CI) 0.65-1.10) and RR 1.15 (95% CI 0.89-1.50) for macrovascular complication, respectively, and RR 1.00 (95% CI 0.80-1.25) and RR 1.06 (95% CI 0.85-1.33) for total mortality, respectively. No essential changes were found in these effects when the follow-up was extended up to 19 years. CONCLUSION: Alpha-tocopherol or beta-carotene supplementation has no protective effect on macrovascular outcomes or total mortality of diabetic male smokers. SN - 1365-2060 UR - https://www.unboundmedicine.com/medline/citation/20350251/Effect_of_alpha_tocopherol_and_beta_carotene_supplementation_on_macrovascular_complications_and_total_mortality_from_diabetes:_results_of_the_ATBC_Study_ L2 - http://www.tandfonline.com/doi/full/10.3109/07853890903508887 DB - PRIME DP - Unbound Medicine ER -