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Effect of alpha-tocopherol and beta-carotene supplementation on macrovascular complications and total mortality from diabetes: results of the ATBC Study.
Ann Med. 2010 Apr; 42(3):178-86.AM

Abstract

AIM

To determine whether alpha-tocopherol or beta-carotene supplementation affects diabetic macrovascular complications and total mortality.

METHODS

This study was carried out as part of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, a double-blind, randomized trial with a 2x2 factorial design. A total of 29,133 middle-aged male smokers received either vitamin E 50 mg/day or beta-carotene 20 mg/day, or both, or placebo for a median of 6.1 years. At base-line, 1700 men had type 2 diabetes. Of these men, 662 were diagnosed with first-ever macrovascular complication, and 1142 died during the 19-year follow-up.

RESULTS

Neither supplementation affected the risk of macrovascular complication or total mortality during the intervention period. For the alpha-tocopherol-supplemented versus no alpha-tocopherol-supplemented, and beta-carotene-supplemented versus no beta-carotene-supplemented we found relative risk (RR) 0.84 (95% confidence interval (CI) 0.65-1.10) and RR 1.15 (95% CI 0.89-1.50) for macrovascular complication, respectively, and RR 1.00 (95% CI 0.80-1.25) and RR 1.06 (95% CI 0.85-1.33) for total mortality, respectively. No essential changes were found in these effects when the follow-up was extended up to 19 years.

CONCLUSION

Alpha-tocopherol or beta-carotene supplementation has no protective effect on macrovascular outcomes or total mortality of diabetic male smokers.

Authors+Show Affiliations

National Institute for Health and Welfare, Mannerheimintie 166, Helsinki, Finland. merja.kataja-tuomola@thl.fiNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20350251

Citation

Kataja-Tuomola, Merja K., et al. "Effect of Alpha-tocopherol and Beta-carotene Supplementation On Macrovascular Complications and Total Mortality From Diabetes: Results of the ATBC Study." Annals of Medicine, vol. 42, no. 3, 2010, pp. 178-86.
Kataja-Tuomola MK, Kontto JP, Männistö S, et al. Effect of alpha-tocopherol and beta-carotene supplementation on macrovascular complications and total mortality from diabetes: results of the ATBC Study. Ann Med. 2010;42(3):178-86.
Kataja-Tuomola, M. K., Kontto, J. P., Männistö, S., Albanes, D., & Virtamo, J. R. (2010). Effect of alpha-tocopherol and beta-carotene supplementation on macrovascular complications and total mortality from diabetes: results of the ATBC Study. Annals of Medicine, 42(3), 178-86. https://doi.org/10.3109/07853890903508887
Kataja-Tuomola MK, et al. Effect of Alpha-tocopherol and Beta-carotene Supplementation On Macrovascular Complications and Total Mortality From Diabetes: Results of the ATBC Study. Ann Med. 2010;42(3):178-86. PubMed PMID: 20350251.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of alpha-tocopherol and beta-carotene supplementation on macrovascular complications and total mortality from diabetes: results of the ATBC Study. AU - Kataja-Tuomola,Merja K, AU - Kontto,Jukka P, AU - Männistö,Satu, AU - Albanes,Demetrius, AU - Virtamo,Jarmo R, PY - 2010/3/31/entrez PY - 2010/3/31/pubmed PY - 2010/6/19/medline SP - 178 EP - 86 JF - Annals of medicine JO - Ann. Med. VL - 42 IS - 3 N2 - AIM: To determine whether alpha-tocopherol or beta-carotene supplementation affects diabetic macrovascular complications and total mortality. METHODS: This study was carried out as part of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study, a double-blind, randomized trial with a 2x2 factorial design. A total of 29,133 middle-aged male smokers received either vitamin E 50 mg/day or beta-carotene 20 mg/day, or both, or placebo for a median of 6.1 years. At base-line, 1700 men had type 2 diabetes. Of these men, 662 were diagnosed with first-ever macrovascular complication, and 1142 died during the 19-year follow-up. RESULTS: Neither supplementation affected the risk of macrovascular complication or total mortality during the intervention period. For the alpha-tocopherol-supplemented versus no alpha-tocopherol-supplemented, and beta-carotene-supplemented versus no beta-carotene-supplemented we found relative risk (RR) 0.84 (95% confidence interval (CI) 0.65-1.10) and RR 1.15 (95% CI 0.89-1.50) for macrovascular complication, respectively, and RR 1.00 (95% CI 0.80-1.25) and RR 1.06 (95% CI 0.85-1.33) for total mortality, respectively. No essential changes were found in these effects when the follow-up was extended up to 19 years. CONCLUSION: Alpha-tocopherol or beta-carotene supplementation has no protective effect on macrovascular outcomes or total mortality of diabetic male smokers. SN - 1365-2060 UR - https://www.unboundmedicine.com/medline/citation/20350251/Effect_of_alpha_tocopherol_and_beta_carotene_supplementation_on_macrovascular_complications_and_total_mortality_from_diabetes:_results_of_the_ATBC_Study_ L2 - http://www.tandfonline.com/doi/full/10.3109/07853890903508887 DB - PRIME DP - Unbound Medicine ER -