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A prospective study of salvage high-intensity focused ultrasound for locally radiorecurrent prostate cancer: early results.
Scand J Urol Nephrol. 2010 Sep; 44(4):223-7.SJ

Abstract

OBJECTIVE

After radical external beam radiation therapy (EBRT), local recurrence may benefit from definitive local therapy. The objective of this study was to evaluate the safety and short-term biochemical results and morbidity after salvage high-intensity focused ultrasound (HIFU) treatment in patients with biopsy-proven local prostate cancer recurrence after EBRT.

MATERIAL AND METHODS

From October 2006 46 patients were treated with HIFU. Bone scan and abdominal CT/MRI scan were negative. Median follow-up was 9 months (range 3-24 months).

RESULTS

The median prostate-specific antigen (PSA) nadir was 0.3 ng/ml (range 0-24 ng/ml). Eighteen patients (39.1%) were classified as failures. In addition, there were four patients (8.7%) with post-HIFU PSA nadir > 0.5 ng/ml. No patients died during follow-up. One patient developed urethrorectal fistulae and was successfully treated conservatively. Two patients developed urethrocutaneous fistulae. Seven patients (15.2%) and one patient (2.1%) developed grade 2 and grade 3 incontinence, respectively. Seven men (15.2%) had erectile function sufficient for intercourse pre-HIFU and only two men (4.3%) post-HIFU.

CONCLUSIONS

Early results of salvage HIFU in patients with local recurrence of prostate cancer after radical EBRT indicate the procedure to be a reasonable treatment option, but better patient selection criteria are needed. The side-effects are not negligible.

Authors+Show Affiliations

Department of Urology, Oslo University Hospital, Aker, Oslo, Norway. viktbe@online.noNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

20350272

Citation

Berge, Viktor, et al. "A Prospective Study of Salvage High-intensity Focused Ultrasound for Locally Radiorecurrent Prostate Cancer: Early Results." Scandinavian Journal of Urology and Nephrology, vol. 44, no. 4, 2010, pp. 223-7.
Berge V, Baco E, Karlsen SJ. A prospective study of salvage high-intensity focused ultrasound for locally radiorecurrent prostate cancer: early results. Scand J Urol Nephrol. 2010;44(4):223-7.
Berge, V., Baco, E., & Karlsen, S. J. (2010). A prospective study of salvage high-intensity focused ultrasound for locally radiorecurrent prostate cancer: early results. Scandinavian Journal of Urology and Nephrology, 44(4), 223-7. https://doi.org/10.3109/00365591003727551
Berge V, Baco E, Karlsen SJ. A Prospective Study of Salvage High-intensity Focused Ultrasound for Locally Radiorecurrent Prostate Cancer: Early Results. Scand J Urol Nephrol. 2010;44(4):223-7. PubMed PMID: 20350272.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A prospective study of salvage high-intensity focused ultrasound for locally radiorecurrent prostate cancer: early results. AU - Berge,Viktor, AU - Baco,Eduard, AU - Karlsen,Steinar Johan, PY - 2010/3/31/entrez PY - 2010/3/31/pubmed PY - 2010/12/17/medline SP - 223 EP - 7 JF - Scandinavian journal of urology and nephrology JO - Scand J Urol Nephrol VL - 44 IS - 4 N2 - OBJECTIVE: After radical external beam radiation therapy (EBRT), local recurrence may benefit from definitive local therapy. The objective of this study was to evaluate the safety and short-term biochemical results and morbidity after salvage high-intensity focused ultrasound (HIFU) treatment in patients with biopsy-proven local prostate cancer recurrence after EBRT. MATERIAL AND METHODS: From October 2006 46 patients were treated with HIFU. Bone scan and abdominal CT/MRI scan were negative. Median follow-up was 9 months (range 3-24 months). RESULTS: The median prostate-specific antigen (PSA) nadir was 0.3 ng/ml (range 0-24 ng/ml). Eighteen patients (39.1%) were classified as failures. In addition, there were four patients (8.7%) with post-HIFU PSA nadir > 0.5 ng/ml. No patients died during follow-up. One patient developed urethrorectal fistulae and was successfully treated conservatively. Two patients developed urethrocutaneous fistulae. Seven patients (15.2%) and one patient (2.1%) developed grade 2 and grade 3 incontinence, respectively. Seven men (15.2%) had erectile function sufficient for intercourse pre-HIFU and only two men (4.3%) post-HIFU. CONCLUSIONS: Early results of salvage HIFU in patients with local recurrence of prostate cancer after radical EBRT indicate the procedure to be a reasonable treatment option, but better patient selection criteria are needed. The side-effects are not negligible. SN - 1651-2065 UR - https://www.unboundmedicine.com/medline/citation/20350272/A_prospective_study_of_salvage_high_intensity_focused_ultrasound_for_locally_radiorecurrent_prostate_cancer:_early_results_ L2 - https://www.tandfonline.com/doi/full/10.3109/00365591003727551 DB - PRIME DP - Unbound Medicine ER -