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Nigral neurodegeneration triggered by striatal AdIL-1 administration can be exacerbated by systemic IL-1 expression.
J Neuroimmunol. 2010 May; 222(1-2):29-39.JN

Abstract

Neuroinflammation has been proposed as an important component of Parkinson's Disease (PD) aetiology and/or progression. However, the inflammatory components and the mechanisms underlying their effects are only partially known. By injecting an adenovirus expressing IL-1 in the striatum, we provoked progressive neurodegeneration of dopaminergic cells in the substantia nigra, motor symptoms and microglial activation. All these effects were attenuated by an anti-inflammatory treatment. Interestingly, peripheral inflammatory stimuli exacerbated IL-1beta induced neurodegeneration and the central inflammatory reaction. These data provide evidence that central, chronic IL-1beta expression can trigger and systemic IL-1beta exacerbate nigral neurodegeneration and highlight the functional relevance of this cytokine in PD.

Authors+Show Affiliations

Laboratory of Regenerative and Protective Therapies of the Nervous System, Foundation Leloir Institute, IIBBA-CONICET, 435, Av Patricias Argentinas, (1405) Buenos Aires, Argentina.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20350768

Citation

Pott Godoy, María Clara, et al. "Nigral Neurodegeneration Triggered By Striatal AdIL-1 Administration Can Be Exacerbated By Systemic IL-1 Expression." Journal of Neuroimmunology, vol. 222, no. 1-2, 2010, pp. 29-39.
Pott Godoy MC, Ferrari CC, Pitossi FJ. Nigral neurodegeneration triggered by striatal AdIL-1 administration can be exacerbated by systemic IL-1 expression. J Neuroimmunol. 2010;222(1-2):29-39.
Pott Godoy, M. C., Ferrari, C. C., & Pitossi, F. J. (2010). Nigral neurodegeneration triggered by striatal AdIL-1 administration can be exacerbated by systemic IL-1 expression. Journal of Neuroimmunology, 222(1-2), 29-39. https://doi.org/10.1016/j.jneuroim.2010.02.018
Pott Godoy MC, Ferrari CC, Pitossi FJ. Nigral Neurodegeneration Triggered By Striatal AdIL-1 Administration Can Be Exacerbated By Systemic IL-1 Expression. J Neuroimmunol. 2010;222(1-2):29-39. PubMed PMID: 20350768.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nigral neurodegeneration triggered by striatal AdIL-1 administration can be exacerbated by systemic IL-1 expression. AU - Pott Godoy,María Clara, AU - Ferrari,Carina Cintia, AU - Pitossi,Fernando Juan, Y1 - 2010/03/29/ PY - 2010/01/04/received PY - 2010/02/22/revised PY - 2010/02/22/accepted PY - 2010/3/31/entrez PY - 2010/3/31/pubmed PY - 2010/6/15/medline SP - 29 EP - 39 JF - Journal of neuroimmunology JO - J Neuroimmunol VL - 222 IS - 1-2 N2 - Neuroinflammation has been proposed as an important component of Parkinson's Disease (PD) aetiology and/or progression. However, the inflammatory components and the mechanisms underlying their effects are only partially known. By injecting an adenovirus expressing IL-1 in the striatum, we provoked progressive neurodegeneration of dopaminergic cells in the substantia nigra, motor symptoms and microglial activation. All these effects were attenuated by an anti-inflammatory treatment. Interestingly, peripheral inflammatory stimuli exacerbated IL-1beta induced neurodegeneration and the central inflammatory reaction. These data provide evidence that central, chronic IL-1beta expression can trigger and systemic IL-1beta exacerbate nigral neurodegeneration and highlight the functional relevance of this cytokine in PD. SN - 1872-8421 UR - https://www.unboundmedicine.com/medline/citation/20350768/Nigral_neurodegeneration_triggered_by_striatal_AdIL_1_administration_can_be_exacerbated_by_systemic_IL_1_expression_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-5728(10)00085-8 DB - PRIME DP - Unbound Medicine ER -