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Assessment of World Health Organization definition of dengue hemorrhagic fever in North India.
J Infect Dev Ctries. 2010 Mar 29; 4(3):150-5.JI

Abstract

BACKGROUND

Classification of symptomatic dengue according to current World Health Organization (WHO) criteria is not straightforward. In this prospective study of dengue infection during an epidemic in India in 2004, we applied the WHO classification of dengue to assess its usefulness for our patients.

METHODOLOGY

The study included 145 clinically suspected cases of dengue infection of all ages. Dengue was confirmed by serological methods (IgM ELISA and HI test). WHO criteria were applied to classify dengue positive patients into Dengue Fever (DF), Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). Clinical and laboratory parameters were compared between dengue patients with bleeding and those without bleeding.

RESULTS

Out of the 50 serologically positive cases of dengue enrolled in the study, only 3 met the WHO criteria for DHF and 1 met the criteria for DSS; however, 21 (42%) cases had one or more bleeding manifestations.

CONCLUSION

By using WHO criteria of DHF on Indian patients, all severe cases of dengue cannot be correctly classified. A new definition of DHF that considers geographic and age-related variations in laboratory and clinical parameters is urgently required.

Authors+Show Affiliations

1Department of Microbiology, Chhatrapati Shahuji Maharaj Medical University, Lucknow, UP, India. prashantgupta46@hotmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Evaluation Study
Journal Article

Language

eng

PubMed ID

20351455

Citation

Gupta, Prashant, et al. "Assessment of World Health Organization Definition of Dengue Hemorrhagic Fever in North India." Journal of Infection in Developing Countries, vol. 4, no. 3, 2010, pp. 150-5.
Gupta P, Khare V, Tripathi S, et al. Assessment of World Health Organization definition of dengue hemorrhagic fever in North India. J Infect Dev Ctries. 2010;4(3):150-5.
Gupta, P., Khare, V., Tripathi, S., Nag, V. L., Kumar, R., Khan, M. Y., & Dhole, T. K. (2010). Assessment of World Health Organization definition of dengue hemorrhagic fever in North India. Journal of Infection in Developing Countries, 4(3), 150-5.
Gupta P, et al. Assessment of World Health Organization Definition of Dengue Hemorrhagic Fever in North India. J Infect Dev Ctries. 2010 Mar 29;4(3):150-5. PubMed PMID: 20351455.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Assessment of World Health Organization definition of dengue hemorrhagic fever in North India. AU - Gupta,Prashant, AU - Khare,Vineeta, AU - Tripathi,Sanjeev, AU - Nag,Vijaya Lakshmi, AU - Kumar,Rashmi, AU - Khan,Mohammad Yahiya, AU - Dhole,Tapan Kumar Nirod Chandra, Y1 - 2010/03/29/ PY - 2009/11/28/received PY - 2009/12/01/accepted PY - 2010/01/13/revised PY - 2010/3/31/entrez PY - 2010/3/31/pubmed PY - 2010/6/17/medline SP - 150 EP - 5 JF - Journal of infection in developing countries JO - J Infect Dev Ctries VL - 4 IS - 3 N2 - BACKGROUND: Classification of symptomatic dengue according to current World Health Organization (WHO) criteria is not straightforward. In this prospective study of dengue infection during an epidemic in India in 2004, we applied the WHO classification of dengue to assess its usefulness for our patients. METHODOLOGY: The study included 145 clinically suspected cases of dengue infection of all ages. Dengue was confirmed by serological methods (IgM ELISA and HI test). WHO criteria were applied to classify dengue positive patients into Dengue Fever (DF), Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). Clinical and laboratory parameters were compared between dengue patients with bleeding and those without bleeding. RESULTS: Out of the 50 serologically positive cases of dengue enrolled in the study, only 3 met the WHO criteria for DHF and 1 met the criteria for DSS; however, 21 (42%) cases had one or more bleeding manifestations. CONCLUSION: By using WHO criteria of DHF on Indian patients, all severe cases of dengue cannot be correctly classified. A new definition of DHF that considers geographic and age-related variations in laboratory and clinical parameters is urgently required. SN - 1972-2680 UR - https://www.unboundmedicine.com/medline/citation/20351455/Assessment_of_World_Health_Organization_definition_of_dengue_hemorrhagic_fever_in_North_India_ L2 - http://www.jidc.org/index.php/journal/article/view/20351455 DB - PRIME DP - Unbound Medicine ER -