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Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet.
Int J Obes (Lond) 2010; 34(8):1341-4IJ

Abstract

High-calorie diet has been shown to impair learning ability and hippocampal synaptic plasticity in rodents. This study examined effects of daily treatment with the glucagon-like peptide-1 mimetic, exendin-4, on cognitive function and hippocampal synaptic plasticity in a model of diet-induced obesity, which exhibits compromised cognitive performance. Mice fed a high-fat diet were treated with exendin-4 (25 nmol kg(-1) bodyweight; twice daily) or saline vehicle (0.9% (w/v) NaCl) over 21 days. In addition to improving metabolic control, exendin-4-treated mice exhibited a marked increase in recognition index highlighting improved learning and memory. High-fat diet resulted in the elimination of in vivo electrophysiological long-term potentiation, which was rescued following exendin-4 treatment. This study shows that exendin-4 therapy improves cognitive function and ameliorates impaired hippocampal synaptic plasticity in dietary-induced obesity.

Authors+Show Affiliations

The SAAD Centre for Pharmacy and Diabetes, School of Biomedical Sciences, University of Ulster, Coleraine, Northern Ireland, UK. va.gault@ulster.ac.ukNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20351729

Citation

Gault, V A., et al. "Actions of Exendin-4 Therapy On Cognitive Function and Hippocampal Synaptic Plasticity in Mice Fed a High-fat Diet." International Journal of Obesity (2005), vol. 34, no. 8, 2010, pp. 1341-4.
Gault VA, Porter WD, Flatt PR, et al. Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet. Int J Obes (Lond). 2010;34(8):1341-4.
Gault, V. A., Porter, W. D., Flatt, P. R., & Hölscher, C. (2010). Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet. International Journal of Obesity (2005), 34(8), pp. 1341-4. doi:10.1038/ijo.2010.59.
Gault VA, et al. Actions of Exendin-4 Therapy On Cognitive Function and Hippocampal Synaptic Plasticity in Mice Fed a High-fat Diet. Int J Obes (Lond). 2010;34(8):1341-4. PubMed PMID: 20351729.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Actions of exendin-4 therapy on cognitive function and hippocampal synaptic plasticity in mice fed a high-fat diet. AU - Gault,V A, AU - Porter,W D, AU - Flatt,P R, AU - Hölscher,C, Y1 - 2010/03/30/ PY - 2010/3/31/entrez PY - 2010/3/31/pubmed PY - 2011/2/10/medline SP - 1341 EP - 4 JF - International journal of obesity (2005) JO - Int J Obes (Lond) VL - 34 IS - 8 N2 - High-calorie diet has been shown to impair learning ability and hippocampal synaptic plasticity in rodents. This study examined effects of daily treatment with the glucagon-like peptide-1 mimetic, exendin-4, on cognitive function and hippocampal synaptic plasticity in a model of diet-induced obesity, which exhibits compromised cognitive performance. Mice fed a high-fat diet were treated with exendin-4 (25 nmol kg(-1) bodyweight; twice daily) or saline vehicle (0.9% (w/v) NaCl) over 21 days. In addition to improving metabolic control, exendin-4-treated mice exhibited a marked increase in recognition index highlighting improved learning and memory. High-fat diet resulted in the elimination of in vivo electrophysiological long-term potentiation, which was rescued following exendin-4 treatment. This study shows that exendin-4 therapy improves cognitive function and ameliorates impaired hippocampal synaptic plasticity in dietary-induced obesity. SN - 1476-5497 UR - https://www.unboundmedicine.com/medline/citation/20351729/Actions_of_exendin_4_therapy_on_cognitive_function_and_hippocampal_synaptic_plasticity_in_mice_fed_a_high_fat_diet_ L2 - http://dx.doi.org/10.1038/ijo.2010.59 DB - PRIME DP - Unbound Medicine ER -