Tags

Type your tag names separated by a space and hit enter

[Risk factors for Parkinson disease: an epidemiologic study].
Acta Med Port 2010 Jan-Feb; 23(1):15-24AM

Abstract

The etiology of Parkinson's disease (PD) remains in a certain part unknown. Both genetic susceptibility and environmental factors are sometimes considered to be putative contributors to its origin. Recent epidemiologic studies have focused on the possible role of environmental risk factors present during adult life or aging, once pure genetic forms of PD are rare. The purpose of this study was to investigate possible environmental and familial risk factors for PD. We performed a hospital based case-control study using 88 PD patients with neurologist confirmed diagnostic, and 176 sex, age, and residence similar controls. Several possible risk factors were evaluated related to life style, past history, family history, occupational history and other exposures to potential neurotoxin agents. Statistical differences, using a 95% confidence interval, were observed in positive family history of PD (p = 0,002), occupation category (p = 0,001), rural living (p = 0,037), living/working near a industry (p = 0,017), exposure to pesticides, herbicides and in-secticides (p < 0,001), coffee consumption (p = 0,036) and tea consumption (p = 0,001). Sex and age adjusted logistic regression showed as potential risk factors, a positive family history of PD (odds ratio [OR] = 9,996; 95% confidence interval [CI] = 2,19-45,597), blue collar occupations (OR = 3,967; 95% CI = 1,670-9,426), exposure to pesticides, herbicides and insecticides (OR = 2,619 ; 95% CI = 1,170-5,862). An inverse relationship was found between tea consumption and the risk of PD (OR = 0,356; 95% CI = 0,174-0,727). The results of the study show that both familial and environmental factors may contribute to the development of PD. Like other studies suggest, PD is of unknown, but presumably multifactorial etiology.

Authors+Show Affiliations

Serviço de Higiene e Epidemiologia, Faculdade de Medicina da Universidade do Porto, Porto.No affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

por

PubMed ID

20353703

Citation

Pereira, Duarte, and Carolina Garrett. "[Risk Factors for Parkinson Disease: an Epidemiologic Study]." Acta Medica Portuguesa, vol. 23, no. 1, 2010, pp. 15-24.
Pereira D, Garrett C. [Risk factors for Parkinson disease: an epidemiologic study]. Acta Med Port. 2010;23(1):15-24.
Pereira, D., & Garrett, C. (2010). [Risk factors for Parkinson disease: an epidemiologic study]. Acta Medica Portuguesa, 23(1), pp. 15-24.
Pereira D, Garrett C. [Risk Factors for Parkinson Disease: an Epidemiologic Study]. Acta Med Port. 2010;23(1):15-24. PubMed PMID: 20353703.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Risk factors for Parkinson disease: an epidemiologic study]. AU - Pereira,Duarte, AU - Garrett,Carolina, Y1 - 2010/02/10/ PY - 2008/09/17/received PY - 2009/03/24/accepted PY - 2010/4/1/entrez PY - 2010/4/1/pubmed PY - 2010/7/21/medline SP - 15 EP - 24 JF - Acta medica portuguesa JO - Acta Med Port VL - 23 IS - 1 N2 - The etiology of Parkinson's disease (PD) remains in a certain part unknown. Both genetic susceptibility and environmental factors are sometimes considered to be putative contributors to its origin. Recent epidemiologic studies have focused on the possible role of environmental risk factors present during adult life or aging, once pure genetic forms of PD are rare. The purpose of this study was to investigate possible environmental and familial risk factors for PD. We performed a hospital based case-control study using 88 PD patients with neurologist confirmed diagnostic, and 176 sex, age, and residence similar controls. Several possible risk factors were evaluated related to life style, past history, family history, occupational history and other exposures to potential neurotoxin agents. Statistical differences, using a 95% confidence interval, were observed in positive family history of PD (p = 0,002), occupation category (p = 0,001), rural living (p = 0,037), living/working near a industry (p = 0,017), exposure to pesticides, herbicides and in-secticides (p < 0,001), coffee consumption (p = 0,036) and tea consumption (p = 0,001). Sex and age adjusted logistic regression showed as potential risk factors, a positive family history of PD (odds ratio [OR] = 9,996; 95% confidence interval [CI] = 2,19-45,597), blue collar occupations (OR = 3,967; 95% CI = 1,670-9,426), exposure to pesticides, herbicides and insecticides (OR = 2,619 ; 95% CI = 1,170-5,862). An inverse relationship was found between tea consumption and the risk of PD (OR = 0,356; 95% CI = 0,174-0,727). The results of the study show that both familial and environmental factors may contribute to the development of PD. Like other studies suggest, PD is of unknown, but presumably multifactorial etiology. SN - 1646-0758 UR - https://www.unboundmedicine.com/medline/citation/20353703/[Risk_factors_for_Parkinson_disease:_an_epidemiologic_study]_ L2 - http://www.actamedicaportuguesa.com/revista/index.php/amp/article/view/599/283 DB - PRIME DP - Unbound Medicine ER -