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Primary graft dysfunction: definition, risk factors, short- and long-term outcomes.
Semin Respir Crit Care Med 2010; 31(2):161-71SR

Abstract

Primary graft dysfunction (PGD) is a form of early lung graft dysfunction that is a major cause of early morbidity and mortality following lung transplantation. Survivors of PGD have decreased long-term lung function and an increased risk of developing bronchiolitis obliterans syndrome (BOS), a manifestation of chronic graft dysfunction. This article reviews the current definition, contributing factors, and guidelines for grading clinical PGD, as well as controversies surrounding them. The current literature examining clinical risk factors for PGD is summarized, as are studies exploring molecular and biochemical markers for PGD prediction and severity. Studies examining the short- and long-term effects of PGD on lung transplant outcomes are reviewed. Lastly, we highlight the emerging concepts in lung transplantation that will potentially impact PGD incidence and outcomes.

Authors+Show Affiliations

Division of Pulmonary, Allergy, and Critical Care Medicine, University of Pennsylvania School of Medicine, Philadelphia, Pennsylvania 19104, USA. james.lee@uphs.upenn.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20354929

Citation

Lee, James C., et al. "Primary Graft Dysfunction: Definition, Risk Factors, Short- and Long-term Outcomes." Seminars in Respiratory and Critical Care Medicine, vol. 31, no. 2, 2010, pp. 161-71.
Lee JC, Christie JD, Keshavjee S. Primary graft dysfunction: definition, risk factors, short- and long-term outcomes. Semin Respir Crit Care Med. 2010;31(2):161-71.
Lee, J. C., Christie, J. D., & Keshavjee, S. (2010). Primary graft dysfunction: definition, risk factors, short- and long-term outcomes. Seminars in Respiratory and Critical Care Medicine, 31(2), pp. 161-71. doi:10.1055/s-0030-1249111.
Lee JC, Christie JD, Keshavjee S. Primary Graft Dysfunction: Definition, Risk Factors, Short- and Long-term Outcomes. Semin Respir Crit Care Med. 2010;31(2):161-71. PubMed PMID: 20354929.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Primary graft dysfunction: definition, risk factors, short- and long-term outcomes. AU - Lee,James C, AU - Christie,Jason D, AU - Keshavjee,Shaf, Y1 - 2010/03/30/ PY - 2010/4/1/entrez PY - 2010/4/1/pubmed PY - 2010/7/2/medline SP - 161 EP - 71 JF - Seminars in respiratory and critical care medicine JO - Semin Respir Crit Care Med VL - 31 IS - 2 N2 - Primary graft dysfunction (PGD) is a form of early lung graft dysfunction that is a major cause of early morbidity and mortality following lung transplantation. Survivors of PGD have decreased long-term lung function and an increased risk of developing bronchiolitis obliterans syndrome (BOS), a manifestation of chronic graft dysfunction. This article reviews the current definition, contributing factors, and guidelines for grading clinical PGD, as well as controversies surrounding them. The current literature examining clinical risk factors for PGD is summarized, as are studies exploring molecular and biochemical markers for PGD prediction and severity. Studies examining the short- and long-term effects of PGD on lung transplant outcomes are reviewed. Lastly, we highlight the emerging concepts in lung transplantation that will potentially impact PGD incidence and outcomes. SN - 1098-9048 UR - https://www.unboundmedicine.com/medline/citation/20354929/Primary_graft_dysfunction:_definition_risk_factors_short__and_long_term_outcomes_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0030-1249111 DB - PRIME DP - Unbound Medicine ER -