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Analgesic and anti-inflammatory effects of Pistacia integerrima extracts in mice.
J Ethnopharmacol. 2010 May 27; 129(2):250-3.JE

Abstract

AIM OF STUDY

Extracts of Pistacia integerrima galls have been dispensed by Traditional Practitioners of Subcontinent for chest diseases as well as for aches and pains in the body. This study was planned to evaluate the possible analgesic and antiinflammatory effects of Pistacia integerrima extracts.

MATERIALS AND METHODS

Analgesia was determined using acetic acid induced abdominal constriction and formalin induced paw licking in mice. Antinociceptive effect was observed by thermally induced algesia in mice.

RESULTS

Pistacia integerrima leaves extracts showed significant response against chemically induced pain (P<0.001) whereas galls extracts had highly significant protection (P<0.0001) in a dose dependent manner. In thermally induced algesia, Pistacia integerrima galls extracts 200 mg/kg (p.o.), showed significant (P<0.05) response but less than pentazocine and diclofenac, positive references. The extracts of Pistacia integerrima 50-200 mg/kg (p.o.) had modest activity against hind paw acute and chronic inflammation induced by formalin (P<0.01).

CONCLUSION

These results demonstrate that Pistacia integerrima extracts have antinociceptive and analgesic effects and no apparent acute toxicity on oral administration.

Authors+Show Affiliations

Department of Pharmacology, Wah Medical College Wah Cantt, University of Health Sciences, Lahore, Khayaban-e-Jamia Punjab, Lahore, Pakistan. saudnaseem@yahoo.comNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20359528

Citation

Ahmad, Naseem Saud, et al. "Analgesic and Anti-inflammatory Effects of Pistacia Integerrima Extracts in Mice." Journal of Ethnopharmacology, vol. 129, no. 2, 2010, pp. 250-3.
Ahmad NS, Waheed A, Farman M, et al. Analgesic and anti-inflammatory effects of Pistacia integerrima extracts in mice. J Ethnopharmacol. 2010;129(2):250-3.
Ahmad, N. S., Waheed, A., Farman, M., & Qayyum, A. (2010). Analgesic and anti-inflammatory effects of Pistacia integerrima extracts in mice. Journal of Ethnopharmacology, 129(2), 250-3. https://doi.org/10.1016/j.jep.2010.03.017
Ahmad NS, et al. Analgesic and Anti-inflammatory Effects of Pistacia Integerrima Extracts in Mice. J Ethnopharmacol. 2010 May 27;129(2):250-3. PubMed PMID: 20359528.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Analgesic and anti-inflammatory effects of Pistacia integerrima extracts in mice. AU - Ahmad,Naseem Saud, AU - Waheed,Akbar, AU - Farman,Muhammad, AU - Qayyum,Aisha, Y1 - 2010/03/30/ PY - 2009/07/21/received PY - 2010/03/01/revised PY - 2010/03/18/accepted PY - 2010/4/3/entrez PY - 2010/4/3/pubmed PY - 2010/10/29/medline SP - 250 EP - 3 JF - Journal of ethnopharmacology JO - J Ethnopharmacol VL - 129 IS - 2 N2 - AIM OF STUDY: Extracts of Pistacia integerrima galls have been dispensed by Traditional Practitioners of Subcontinent for chest diseases as well as for aches and pains in the body. This study was planned to evaluate the possible analgesic and antiinflammatory effects of Pistacia integerrima extracts. MATERIALS AND METHODS: Analgesia was determined using acetic acid induced abdominal constriction and formalin induced paw licking in mice. Antinociceptive effect was observed by thermally induced algesia in mice. RESULTS: Pistacia integerrima leaves extracts showed significant response against chemically induced pain (P<0.001) whereas galls extracts had highly significant protection (P<0.0001) in a dose dependent manner. In thermally induced algesia, Pistacia integerrima galls extracts 200 mg/kg (p.o.), showed significant (P<0.05) response but less than pentazocine and diclofenac, positive references. The extracts of Pistacia integerrima 50-200 mg/kg (p.o.) had modest activity against hind paw acute and chronic inflammation induced by formalin (P<0.01). CONCLUSION: These results demonstrate that Pistacia integerrima extracts have antinociceptive and analgesic effects and no apparent acute toxicity on oral administration. SN - 1872-7573 UR - https://www.unboundmedicine.com/medline/citation/20359528/Analgesic_and_anti_inflammatory_effects_of_Pistacia_integerrima_extracts_in_mice_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-8741(10)00179-0 DB - PRIME DP - Unbound Medicine ER -