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Immunostimulating effects of a sulfated galactan from Codium fragile.
Carbohydr Res. 2010 Jul 02; 345(10):1452-4.CR

Abstract

A pyruvylated sulfated galactan from Codium fragile is a highly ramified polysaccharide consisting of 3-linked, 3,6-linked, and non-reducing terminal d-galactose with pyruvate and sulfate groups; the glycan exerts anti-herpes simplex virus type 2 effects in vitro and in vivo. This particular polysaccharide was found to stimulate the production of nitric oxide by inducing iNOS at the mRNA and protein levels. In addition, the polysaccharide also induced several cytokine mRNA expressions such as IL-1beta, IL-6, IL-10 and TNF-alpha. Therefore, it appears that the sulfated galactan might possess the immunostimulating effects via activation of macrophages.

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Authors+Show Affiliations

Lee JB
Graduate School of Medicine and Pharmaceutical Sciences for Research, University of Toyama, 2630 Sugitani, Toyama, Toyama 930-0194, Japan.
Ohta Y
No affiliation info available
Hayashi K
No affiliation info available
Hayashi T
No affiliation info available

MeSH

Adjuvants, ImmunologicAnimalsCell LineChlorophytaCytokinesGalactansGene Expression Regulation, EnzymologicMacrophagesMiceNitric OxideNitric Oxide Synthase Type IIRNA, MessengerSulfuric Acids

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20362278

Citation

Lee, Jung-Bum, et al. "Immunostimulating Effects of a Sulfated Galactan From Codium Fragile." Carbohydrate Research, vol. 345, no. 10, 2010, pp. 1452-4.
Lee JB, Ohta Y, Hayashi K, et al. Immunostimulating effects of a sulfated galactan from Codium fragile. Carbohydr Res. 2010;345(10):1452-4.
Lee, J. B., Ohta, Y., Hayashi, K., & Hayashi, T. (2010). Immunostimulating effects of a sulfated galactan from Codium fragile. Carbohydrate Research, 345(10), 1452-4. https://doi.org/10.1016/j.carres.2010.02.026
Lee JB, et al. Immunostimulating Effects of a Sulfated Galactan From Codium Fragile. Carbohydr Res. 2010 Jul 2;345(10):1452-4. PubMed PMID: 20362278.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Immunostimulating effects of a sulfated galactan from Codium fragile. AU - Lee,Jung-Bum, AU - Ohta,Yuko, AU - Hayashi,Kyoko, AU - Hayashi,Toshimitsu, Y1 - 2010/03/03/ PY - 2010/01/06/received PY - 2010/02/24/revised PY - 2010/02/26/accepted PY - 2010/4/6/entrez PY - 2010/4/7/pubmed PY - 2010/10/29/medline SP - 1452 EP - 4 JF - Carbohydrate research JO - Carbohydr Res VL - 345 IS - 10 N2 - A pyruvylated sulfated galactan from Codium fragile is a highly ramified polysaccharide consisting of 3-linked, 3,6-linked, and non-reducing terminal d-galactose with pyruvate and sulfate groups; the glycan exerts anti-herpes simplex virus type 2 effects in vitro and in vivo. This particular polysaccharide was found to stimulate the production of nitric oxide by inducing iNOS at the mRNA and protein levels. In addition, the polysaccharide also induced several cytokine mRNA expressions such as IL-1beta, IL-6, IL-10 and TNF-alpha. Therefore, it appears that the sulfated galactan might possess the immunostimulating effects via activation of macrophages. SN - 1873-426X UR - https://www.unboundmedicine.com/medline/citation/20362278/Immunostimulating_effects_of_a_sulfated_galactan_from_Codium_fragile_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0008-6215(10)00084-4 DB - PRIME DP - Unbound Medicine ER -