TY - JOUR T1 - Antihyperglycemic effect of diosmin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats. AU - Pari,Leelavinothan, AU - Srinivasan,Subramani, Y1 - 2010/02/23/ PY - 2009/09/17/received PY - 2010/02/01/accepted PY - 2010/4/6/entrez PY - 2010/4/7/pubmed PY - 2011/2/15/medline SP - 477 EP - 81 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed Pharmacother VL - 64 IS - 7 N2 - The purpose of this study was to investigate the effect of diosmin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats. Diosmin was administered to streptozotocin-induced (45 mg/kg b.w) diabetic rats at different doses (25, 50, 100 mg/kg b.w) for 45 days to assess its effect on fasting plasma glucose, insulin, glycosylated hemoglobin, hemoglobin and carbohydrate metabolic enzymes, it was found that plasma glucose was significantly reduced in a dose-dependent manner when compared to the diabetic control. In addition, oral administration of diosmin (100mg/kg b.w) significantly decreased glycosylated hemoglobin and increased hemoglobin and plasma insulin. The activities of the hepatic key enzymes such as hexokinase and glucose-6-phosphate dehydrogenase were significantly increased whereas, glucose-6-phosphatase and fructose-1,6-bisphosphatase were significantly decreased. Furthermore, protection against body weight loss of diabetic animals was also observed. These results showed that diosmin has potential antihyperglycemic activity in streptozotocin-nicotinamide-induced diabetic rats. SN - 1950-6007 UR - https://www.unboundmedicine.com/medline/citation/20362409/Antihyperglycemic_effect_of_diosmin_on_hepatic_key_enzymes_of_carbohydrate_metabolism_in_streptozotocin_nicotinamide_induced_diabetic_rats_ DB - PRIME DP - Unbound Medicine ER -