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Antihyperglycemic effect of diosmin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats.
Biomed Pharmacother. 2010 Sep; 64(7):477-81.BP

Abstract

The purpose of this study was to investigate the effect of diosmin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats. Diosmin was administered to streptozotocin-induced (45 mg/kg b.w) diabetic rats at different doses (25, 50, 100 mg/kg b.w) for 45 days to assess its effect on fasting plasma glucose, insulin, glycosylated hemoglobin, hemoglobin and carbohydrate metabolic enzymes, it was found that plasma glucose was significantly reduced in a dose-dependent manner when compared to the diabetic control. In addition, oral administration of diosmin (100mg/kg b.w) significantly decreased glycosylated hemoglobin and increased hemoglobin and plasma insulin. The activities of the hepatic key enzymes such as hexokinase and glucose-6-phosphate dehydrogenase were significantly increased whereas, glucose-6-phosphatase and fructose-1,6-bisphosphatase were significantly decreased. Furthermore, protection against body weight loss of diabetic animals was also observed. These results showed that diosmin has potential antihyperglycemic activity in streptozotocin-nicotinamide-induced diabetic rats.

Authors+Show Affiliations

Department of Biochemistry and Biotechnology, Faculty of Science, Annamalai University, Annamalai Nagar, Chidambaram, 608002 Tamilnadu, India. paribalaji@gmail.comNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20362409

Citation

Pari, Leelavinothan, and Subramani Srinivasan. "Antihyperglycemic Effect of Diosmin On Hepatic Key Enzymes of Carbohydrate Metabolism in Streptozotocin-nicotinamide-induced Diabetic Rats." Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, vol. 64, no. 7, 2010, pp. 477-81.
Pari L, Srinivasan S. Antihyperglycemic effect of diosmin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats. Biomed Pharmacother. 2010;64(7):477-81.
Pari, L., & Srinivasan, S. (2010). Antihyperglycemic effect of diosmin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats. Biomedicine & Pharmacotherapy = Biomedecine & Pharmacotherapie, 64(7), 477-81. https://doi.org/10.1016/j.biopha.2010.02.001
Pari L, Srinivasan S. Antihyperglycemic Effect of Diosmin On Hepatic Key Enzymes of Carbohydrate Metabolism in Streptozotocin-nicotinamide-induced Diabetic Rats. Biomed Pharmacother. 2010;64(7):477-81. PubMed PMID: 20362409.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antihyperglycemic effect of diosmin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats. AU - Pari,Leelavinothan, AU - Srinivasan,Subramani, Y1 - 2010/02/23/ PY - 2009/09/17/received PY - 2010/02/01/accepted PY - 2010/4/6/entrez PY - 2010/4/7/pubmed PY - 2011/2/15/medline SP - 477 EP - 81 JF - Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie JO - Biomed Pharmacother VL - 64 IS - 7 N2 - The purpose of this study was to investigate the effect of diosmin on hepatic key enzymes of carbohydrate metabolism in streptozotocin-nicotinamide-induced diabetic rats. Diosmin was administered to streptozotocin-induced (45 mg/kg b.w) diabetic rats at different doses (25, 50, 100 mg/kg b.w) for 45 days to assess its effect on fasting plasma glucose, insulin, glycosylated hemoglobin, hemoglobin and carbohydrate metabolic enzymes, it was found that plasma glucose was significantly reduced in a dose-dependent manner when compared to the diabetic control. In addition, oral administration of diosmin (100mg/kg b.w) significantly decreased glycosylated hemoglobin and increased hemoglobin and plasma insulin. The activities of the hepatic key enzymes such as hexokinase and glucose-6-phosphate dehydrogenase were significantly increased whereas, glucose-6-phosphatase and fructose-1,6-bisphosphatase were significantly decreased. Furthermore, protection against body weight loss of diabetic animals was also observed. These results showed that diosmin has potential antihyperglycemic activity in streptozotocin-nicotinamide-induced diabetic rats. SN - 1950-6007 UR - https://www.unboundmedicine.com/medline/citation/20362409/Antihyperglycemic_effect_of_diosmin_on_hepatic_key_enzymes_of_carbohydrate_metabolism_in_streptozotocin_nicotinamide_induced_diabetic_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0753-3322(10)00032-6 DB - PRIME DP - Unbound Medicine ER -