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The impact of early-onset cannabis use on functional brain correlates of working memory.
Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16; 34(6):837-45.PN

Abstract

Cannabis is the most commonly used illicit drug. Prevalence rates are particularly high among adolescents. Neuropsychological studies have identified cannabis-associated memory deficits, particularly linked to an early onset of use. However, it remains unclear, whether the age of onset accounts for altered cortical activation patterns usually observed in cannabis users. Functional magnetic resonance imaging was used to examine cortical activation during verbal working memory challenge in (1) early-onset (onset before the age of sixteen; n=26) and (2) late-onset cannabis users (age at onset at least sixteen; n=17). Early-onset users showed increased activation in the left superior parietal lobe. Correlational analyses confirmed the association between an earlier start of use and increased activity. Contrariwise neither cumulative dose, frequency nor time since last use was significantly associated with cortical activity. Our findings suggest that an early start of cannabis use is associated with increased cortical activation in adult cannabis users, possibly reflecting suboptimal cortical efficiency during cognitive challenge. The maturing brain might be more vulnerable to the harmful effects of cannabis use. However, due to a lack of a non-using control group we cannot exclude alternative interpretations.

Authors+Show Affiliations

Department of Psychiatry and Psychotherapy, University of Cologne, Cologne, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20363277

Citation

Becker, Benjamin, et al. "The Impact of Early-onset Cannabis Use On Functional Brain Correlates of Working Memory." Progress in Neuro-psychopharmacology & Biological Psychiatry, vol. 34, no. 6, 2010, pp. 837-45.
Becker B, Wagner D, Gouzoulis-Mayfrank E, et al. The impact of early-onset cannabis use on functional brain correlates of working memory. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34(6):837-45.
Becker, B., Wagner, D., Gouzoulis-Mayfrank, E., Spuentrup, E., & Daumann, J. (2010). The impact of early-onset cannabis use on functional brain correlates of working memory. Progress in Neuro-psychopharmacology & Biological Psychiatry, 34(6), 837-45. https://doi.org/10.1016/j.pnpbp.2010.03.032
Becker B, et al. The Impact of Early-onset Cannabis Use On Functional Brain Correlates of Working Memory. Prog Neuropsychopharmacol Biol Psychiatry. 2010 Aug 16;34(6):837-45. PubMed PMID: 20363277.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The impact of early-onset cannabis use on functional brain correlates of working memory. AU - Becker,Benjamin, AU - Wagner,Daniel, AU - Gouzoulis-Mayfrank,Euphrosyne, AU - Spuentrup,Elmar, AU - Daumann,Jörg, Y1 - 2010/04/02/ PY - 2009/12/21/received PY - 2010/03/18/revised PY - 2010/03/25/accepted PY - 2010/4/6/entrez PY - 2010/4/7/pubmed PY - 2010/11/3/medline SP - 837 EP - 45 JF - Progress in neuro-psychopharmacology & biological psychiatry JO - Prog. Neuropsychopharmacol. Biol. Psychiatry VL - 34 IS - 6 N2 - Cannabis is the most commonly used illicit drug. Prevalence rates are particularly high among adolescents. Neuropsychological studies have identified cannabis-associated memory deficits, particularly linked to an early onset of use. However, it remains unclear, whether the age of onset accounts for altered cortical activation patterns usually observed in cannabis users. Functional magnetic resonance imaging was used to examine cortical activation during verbal working memory challenge in (1) early-onset (onset before the age of sixteen; n=26) and (2) late-onset cannabis users (age at onset at least sixteen; n=17). Early-onset users showed increased activation in the left superior parietal lobe. Correlational analyses confirmed the association between an earlier start of use and increased activity. Contrariwise neither cumulative dose, frequency nor time since last use was significantly associated with cortical activity. Our findings suggest that an early start of cannabis use is associated with increased cortical activation in adult cannabis users, possibly reflecting suboptimal cortical efficiency during cognitive challenge. The maturing brain might be more vulnerable to the harmful effects of cannabis use. However, due to a lack of a non-using control group we cannot exclude alternative interpretations. SN - 1878-4216 UR - https://www.unboundmedicine.com/medline/citation/20363277/The_impact_of_early_onset_cannabis_use_on_functional_brain_correlates_of_working_memory_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0278-5846(10)00125-9 DB - PRIME DP - Unbound Medicine ER -