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Complete recovery from undertreated Wernicke-Korsakoff syndrome following aggressive thiamine treatment.
In Vivo. 2010 Mar-Apr; 24(2):231-3.V

Abstract

BACKGROUND

Wernicke-Korsakoff syndrome (WKS) is a neuropsychiatric condition which results from thiamine deficiency, most commonly due to alcohol abuse. The prognosis of WKS is poor and its outcome depends mainly on prompt treatment.

CASE REPORT

A 52-year-old male with a ten-year history of heavy alcohol abuse was admitted in hospital and treated for WKS. Ataxic and oculomotor symptoms promptly reversed following standard treatment but no change was observed in higher mental functioning. Although the protracted WK symptoms made the patient's improvement unlikely, aggressive treatment with thiamine (600 mg/day orally and 300 mg/day intramuscularly) fully reversed the condition within two months.

CONCLUSION

Even though prolongation of undertreatment of WKS typically precludes significant improvement of symptoms due to irreversible damage of the brain, at least in some cases, higher thiamine doses (over 500 mg/day) for a longer period (at least three months) than usually recommended should be tried.

Authors+Show Affiliations

Athens University Medical School, First Department of Psychiatry, Eginition Hospital, 115 28 Athens, Greece. tpaparrig@med.uoa.grNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article

Language

eng

PubMed ID

20364001

Citation

Paparrigopoulos, Thomas, et al. "Complete Recovery From Undertreated Wernicke-Korsakoff Syndrome Following Aggressive Thiamine Treatment." In Vivo (Athens, Greece), vol. 24, no. 2, 2010, pp. 231-3.
Paparrigopoulos T, Tzavellas E, Karaiskos D, et al. Complete recovery from undertreated Wernicke-Korsakoff syndrome following aggressive thiamine treatment. In Vivo. 2010;24(2):231-3.
Paparrigopoulos, T., Tzavellas, E., Karaiskos, D., Kouzoupis, A., & Liappas, I. (2010). Complete recovery from undertreated Wernicke-Korsakoff syndrome following aggressive thiamine treatment. In Vivo (Athens, Greece), 24(2), 231-3.
Paparrigopoulos T, et al. Complete Recovery From Undertreated Wernicke-Korsakoff Syndrome Following Aggressive Thiamine Treatment. In Vivo. 2010 Mar-Apr;24(2):231-3. PubMed PMID: 20364001.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Complete recovery from undertreated Wernicke-Korsakoff syndrome following aggressive thiamine treatment. AU - Paparrigopoulos,Thomas, AU - Tzavellas,Elias, AU - Karaiskos,Dimitris, AU - Kouzoupis,Anastasios, AU - Liappas,Ioannis, PY - 2010/4/6/entrez PY - 2010/4/7/pubmed PY - 2010/5/8/medline SP - 231 EP - 3 JF - In vivo (Athens, Greece) JO - In Vivo VL - 24 IS - 2 N2 - BACKGROUND: Wernicke-Korsakoff syndrome (WKS) is a neuropsychiatric condition which results from thiamine deficiency, most commonly due to alcohol abuse. The prognosis of WKS is poor and its outcome depends mainly on prompt treatment. CASE REPORT: A 52-year-old male with a ten-year history of heavy alcohol abuse was admitted in hospital and treated for WKS. Ataxic and oculomotor symptoms promptly reversed following standard treatment but no change was observed in higher mental functioning. Although the protracted WK symptoms made the patient's improvement unlikely, aggressive treatment with thiamine (600 mg/day orally and 300 mg/day intramuscularly) fully reversed the condition within two months. CONCLUSION: Even though prolongation of undertreatment of WKS typically precludes significant improvement of symptoms due to irreversible damage of the brain, at least in some cases, higher thiamine doses (over 500 mg/day) for a longer period (at least three months) than usually recommended should be tried. SN - 0258-851X UR - https://www.unboundmedicine.com/medline/citation/20364001/Complete_recovery_from_undertreated_Wernicke_Korsakoff_syndrome_following_aggressive_thiamine_treatment_ L2 - http://iv.iiarjournals.org/cgi/pmidlookup?view=long&pmid=20364001 DB - PRIME DP - Unbound Medicine ER -