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hRad21 overexpresses and localizes to the ALT-associated promyelocytic leukemia body in ALT cells.
Cancer Biol Ther. 2010 Jun 15; 9(12):978-83.CB

Abstract

Telomerase-negative immortalized cells maintain their telomeres through a telomerase-independent pathway termed alternative lengthening of telomeres (ALT). The mechanism of ALT is based on homologous recombination (HR). A hallmark of ALT cells is presence of a nuclear structure termed ALT-associated promyelocytic leukemia body (APB). Here, we demonstrated that hRAD21, an important subunit of cohesin complex, was overexpressed in ALT cells. We additionally showed that hRAD21 protein localized to APB in ALT cells. Thus, one role of hRAD21 appeared to involve telomere maintenance in ALT cells. We suggested that hRAD21 facilitated telomere HR in ALT cells by participating in APB formation.

Authors+Show Affiliations

Department of General Surgery, Beijing Chaoyang Hospital, Capital Medical University, Chaoyang District, Beijing, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20364118

Citation

Zhao, Bo, et al. "HRad21 Overexpresses and Localizes to the ALT-associated Promyelocytic Leukemia Body in ALT Cells." Cancer Biology & Therapy, vol. 9, no. 12, 2010, pp. 978-83.
Zhao B, Wang ZJ, Yi BQ, et al. HRad21 overexpresses and localizes to the ALT-associated promyelocytic leukemia body in ALT cells. Cancer Biol Ther. 2010;9(12):978-83.
Zhao, B., Wang, Z. J., Yi, B. Q., Ma, H. C., & Xu, H. M. (2010). HRad21 overexpresses and localizes to the ALT-associated promyelocytic leukemia body in ALT cells. Cancer Biology & Therapy, 9(12), 978-83.
Zhao B, et al. HRad21 Overexpresses and Localizes to the ALT-associated Promyelocytic Leukemia Body in ALT Cells. Cancer Biol Ther. 2010 Jun 15;9(12):978-83. PubMed PMID: 20364118.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - hRad21 overexpresses and localizes to the ALT-associated promyelocytic leukemia body in ALT cells. AU - Zhao,Bo, AU - Wang,Zhen Jun, AU - Yi,Bing Qiang, AU - Ma,Hua Chong, AU - Xu,Hui Min, Y1 - 2010/06/26/ PY - 2010/4/6/entrez PY - 2010/4/7/pubmed PY - 2011/2/22/medline SP - 978 EP - 83 JF - Cancer biology & therapy JO - Cancer Biol. Ther. VL - 9 IS - 12 N2 - Telomerase-negative immortalized cells maintain their telomeres through a telomerase-independent pathway termed alternative lengthening of telomeres (ALT). The mechanism of ALT is based on homologous recombination (HR). A hallmark of ALT cells is presence of a nuclear structure termed ALT-associated promyelocytic leukemia body (APB). Here, we demonstrated that hRAD21, an important subunit of cohesin complex, was overexpressed in ALT cells. We additionally showed that hRAD21 protein localized to APB in ALT cells. Thus, one role of hRAD21 appeared to involve telomere maintenance in ALT cells. We suggested that hRAD21 facilitated telomere HR in ALT cells by participating in APB formation. SN - 1555-8576 UR - https://www.unboundmedicine.com/medline/citation/20364118/hRad21_overexpresses_and_localizes_to_the_ALT_associated_promyelocytic_leukemia_body_in_ALT_cells_ L2 - http://www.tandfonline.com/doi/full/10.4161/cbt.9.12.11636 DB - PRIME DP - Unbound Medicine ER -