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Disseminated, histologically confirmed Cryptococcus spp infection in a domestic ferret.
J Am Vet Med Assoc. 2010 Apr 01; 236(7):770-4.JA

Abstract

CASE DESCRIPTION

A 4-year-old castrated male domestic ferret from central Massachusetts was evaluated for weight loss over a 1.5-month period and for 2 days of retching, diarrhea, and signs of lethargy. It had been housed indoors, with 2 other ferrets, 2 cats, and humans that lacked signs or symptoms of disease.

CLINICAL FINDINGS

Physical examination revealed a thin body condition, tachypnea, an increase in respiratory effort, and retching. Splenomegaly was detected during abdominal palpation. Clinicopathologic analysis revealed lymphopenia, lactic acidosis, hypoglycemia, hypocalcemia, hypoalbuminemia, and hyperglobulinemia. A pulmonary bronchointerstitial pattern was evident on radiographs, and abdominal ultrasonography revealed a suspected pancreatic mass and mesenteric lymphadenopathy.

TREATMENT AND OUTCOME

After 2 weeks of medical treatment and once clinical signs resolved, an exploratory laparotomy was performed and a lymph node biopsy specimen was collected. Histologic evaluation of the specimen revealed Cryptococcus-like organisms. Antifungal treatment was initiated with itraconazole (PO) and amphotericin B (IV). The ferret died after 2 days of treatment. A full necropsy was performed, revealing multicentric cryptococcosis affecting the lungs, brain, spleen, and multiple lymph nodes. Paraffin-embedded, formalin-fixed lung tissue was submitted for DNA extraction, and the organism was identified as Cryptococcus neoformans var grubii.

CLINICAL RELEVANCE

To the authors' knowledge, this is the first report of disseminated cryptococcosis in a North American ferret. This case is unique in that the ferret lived indoors, in a geographic region in which reports of cryptococcosis are rare. The genotyping technique used to identify the Cryptococcus strain can aid in better understanding the epidemiology of cryptococcosis.

Authors+Show Affiliations

Department of Clinical Sciences, Cummings School of Veterinary Medicine, Tufts University, North Grafton, MA 01536, USA. dreshard@gmail.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20367045

Citation

Eshar, David, et al. "Disseminated, Histologically Confirmed Cryptococcus Spp Infection in a Domestic Ferret." Journal of the American Veterinary Medical Association, vol. 236, no. 7, 2010, pp. 770-4.
Eshar D, Mayer J, Parry NM, et al. Disseminated, histologically confirmed Cryptococcus spp infection in a domestic ferret. J Am Vet Med Assoc. 2010;236(7):770-4.
Eshar, D., Mayer, J., Parry, N. M., Williams-Fritze, M. J., & Bradway, D. S. (2010). Disseminated, histologically confirmed Cryptococcus spp infection in a domestic ferret. Journal of the American Veterinary Medical Association, 236(7), 770-4. https://doi.org/10.2460/javma.236.7.770
Eshar D, et al. Disseminated, Histologically Confirmed Cryptococcus Spp Infection in a Domestic Ferret. J Am Vet Med Assoc. 2010 Apr 1;236(7):770-4. PubMed PMID: 20367045.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Disseminated, histologically confirmed Cryptococcus spp infection in a domestic ferret. AU - Eshar,David, AU - Mayer,Jörg, AU - Parry,Nicola M, AU - Williams-Fritze,Misty J, AU - Bradway,Daniel S, PY - 2010/4/7/entrez PY - 2010/4/7/pubmed PY - 2010/5/5/medline SP - 770 EP - 4 JF - Journal of the American Veterinary Medical Association JO - J Am Vet Med Assoc VL - 236 IS - 7 N2 - CASE DESCRIPTION: A 4-year-old castrated male domestic ferret from central Massachusetts was evaluated for weight loss over a 1.5-month period and for 2 days of retching, diarrhea, and signs of lethargy. It had been housed indoors, with 2 other ferrets, 2 cats, and humans that lacked signs or symptoms of disease. CLINICAL FINDINGS: Physical examination revealed a thin body condition, tachypnea, an increase in respiratory effort, and retching. Splenomegaly was detected during abdominal palpation. Clinicopathologic analysis revealed lymphopenia, lactic acidosis, hypoglycemia, hypocalcemia, hypoalbuminemia, and hyperglobulinemia. A pulmonary bronchointerstitial pattern was evident on radiographs, and abdominal ultrasonography revealed a suspected pancreatic mass and mesenteric lymphadenopathy. TREATMENT AND OUTCOME: After 2 weeks of medical treatment and once clinical signs resolved, an exploratory laparotomy was performed and a lymph node biopsy specimen was collected. Histologic evaluation of the specimen revealed Cryptococcus-like organisms. Antifungal treatment was initiated with itraconazole (PO) and amphotericin B (IV). The ferret died after 2 days of treatment. A full necropsy was performed, revealing multicentric cryptococcosis affecting the lungs, brain, spleen, and multiple lymph nodes. Paraffin-embedded, formalin-fixed lung tissue was submitted for DNA extraction, and the organism was identified as Cryptococcus neoformans var grubii. CLINICAL RELEVANCE: To the authors' knowledge, this is the first report of disseminated cryptococcosis in a North American ferret. This case is unique in that the ferret lived indoors, in a geographic region in which reports of cryptococcosis are rare. The genotyping technique used to identify the Cryptococcus strain can aid in better understanding the epidemiology of cryptococcosis. SN - 0003-1488 UR - https://www.unboundmedicine.com/medline/citation/20367045/Disseminated_histologically_confirmed_Cryptococcus_spp_infection_in_a_domestic_ferret_ L2 - https://avmajournals.avma.org/doi/10.2460/javma.236.7.770?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -