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Longitudinal comparison of pre- and postoperative diffusion tensor imaging parameters in young children with hydrocephalus.
J Neurosurg Pediatr. 2010 Apr; 5(4):385-91.JN

Abstract

OBJECT

The goal in this study was to compare the integrity of white matter before and after ventriculoperitoneal (VP) shunt insertion by evaluating the anisotropic diffusion properties with the aid of diffusion tensor (DT) imaging in young children with hydrocephalus.

METHODS

The authors retrospectively identified 10 children with hydrocephalus who underwent both pre- and postoperative DT imaging studies. The DT imaging parameters (fractional anisotropy [FA], mean diffusivity, axial diffusivity, and radial diffusivity) were computed and compared longitudinally in the splenium and genu of the corpus callosum (gCC) and in the anterior and posterior limbs of the internal capsule (PLIC). The patients' values on DT imaging at the pre- and postshunt stages were compared with the corresponding age-matched controls as well as with a large cohort of healthy children in the database.

RESULTS

In the gCC, 7 of 10 children had abnormally low preoperative FA values, 6 of which normalized postoperatively. All 3 of the 10 children who had normal preoperative FA values had normal FA values postoperatively as well. In the PLIC, 7 of 10 children had abnormally high FA values, 6 of which normalized postoperatively, whereas the other one had abnormally low postoperative FA. Of the remaining 3 children, 2 had abnormally low preoperative FA values in the PLIC; this normalized in 1 patient after surgery. The other child had a normal preoperative FA value that became abnormally low postoperatively. When comparing the presurgery frequency of abnormally low, normal, and abnormally high FA values to those postsurgery, there was a statistically significant longitudinal difference in both gCC (p = 0.02) and PLIC (p = 0.002).

CONCLUSIONS

In this first longitudinal DT imaging study of young children with hydrocephalus, DT imaging anisotropy yielded abnormal results in several white matter regions of the brain, and trended toward normalization following VP shunt placement.

Authors+Show Affiliations

Department of Pediatric Neurosurgery, Pediatric Neuroimaging Research Consortium, University of Cincinnati College of Medicine, Cincinnati, Ohio, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20367345

Citation

Air, Ellen L., et al. "Longitudinal Comparison of Pre- and Postoperative Diffusion Tensor Imaging Parameters in Young Children With Hydrocephalus." Journal of Neurosurgery. Pediatrics, vol. 5, no. 4, 2010, pp. 385-91.
Air EL, Yuan W, Holland SK, et al. Longitudinal comparison of pre- and postoperative diffusion tensor imaging parameters in young children with hydrocephalus. J Neurosurg Pediatr. 2010;5(4):385-91.
Air, E. L., Yuan, W., Holland, S. K., Jones, B. V., Bierbrauer, K., Altaye, M., & Mangano, F. T. (2010). Longitudinal comparison of pre- and postoperative diffusion tensor imaging parameters in young children with hydrocephalus. Journal of Neurosurgery. Pediatrics, 5(4), 385-91. https://doi.org/10.3171/2009.11.PEDS09343
Air EL, et al. Longitudinal Comparison of Pre- and Postoperative Diffusion Tensor Imaging Parameters in Young Children With Hydrocephalus. J Neurosurg Pediatr. 2010;5(4):385-91. PubMed PMID: 20367345.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Longitudinal comparison of pre- and postoperative diffusion tensor imaging parameters in young children with hydrocephalus. AU - Air,Ellen L, AU - Yuan,Weihong, AU - Holland,Scott K, AU - Jones,Blaise V, AU - Bierbrauer,Karin, AU - Altaye,Mekibib, AU - Mangano,Francesco T, PY - 2010/4/7/entrez PY - 2010/4/7/pubmed PY - 2010/4/23/medline SP - 385 EP - 91 JF - Journal of neurosurgery. Pediatrics JO - J Neurosurg Pediatr VL - 5 IS - 4 N2 - OBJECT: The goal in this study was to compare the integrity of white matter before and after ventriculoperitoneal (VP) shunt insertion by evaluating the anisotropic diffusion properties with the aid of diffusion tensor (DT) imaging in young children with hydrocephalus. METHODS: The authors retrospectively identified 10 children with hydrocephalus who underwent both pre- and postoperative DT imaging studies. The DT imaging parameters (fractional anisotropy [FA], mean diffusivity, axial diffusivity, and radial diffusivity) were computed and compared longitudinally in the splenium and genu of the corpus callosum (gCC) and in the anterior and posterior limbs of the internal capsule (PLIC). The patients' values on DT imaging at the pre- and postshunt stages were compared with the corresponding age-matched controls as well as with a large cohort of healthy children in the database. RESULTS: In the gCC, 7 of 10 children had abnormally low preoperative FA values, 6 of which normalized postoperatively. All 3 of the 10 children who had normal preoperative FA values had normal FA values postoperatively as well. In the PLIC, 7 of 10 children had abnormally high FA values, 6 of which normalized postoperatively, whereas the other one had abnormally low postoperative FA. Of the remaining 3 children, 2 had abnormally low preoperative FA values in the PLIC; this normalized in 1 patient after surgery. The other child had a normal preoperative FA value that became abnormally low postoperatively. When comparing the presurgery frequency of abnormally low, normal, and abnormally high FA values to those postsurgery, there was a statistically significant longitudinal difference in both gCC (p = 0.02) and PLIC (p = 0.002). CONCLUSIONS: In this first longitudinal DT imaging study of young children with hydrocephalus, DT imaging anisotropy yielded abnormal results in several white matter regions of the brain, and trended toward normalization following VP shunt placement. SN - 1933-0715 UR - https://www.unboundmedicine.com/medline/citation/20367345/Longitudinal_comparison_of_pre__and_postoperative_diffusion_tensor_imaging_parameters_in_young_children_with_hydrocephalus_ L2 - https://thejns.org/doi/10.3171/2009.11.PEDS09343 DB - PRIME DP - Unbound Medicine ER -