Tags

Type your tag names separated by a space and hit enter

Functional Foods as Modifiers of Cardiovascular Disease.

Abstract

There is growing consensus that systemic inflammation is at the heart of cardiovascular disease (CVD). Inflammation is a key feature of the immune system, functioning to defend tissue integrity and function. However, chronic stimulation of inflammatory mediators leads to lasting vascular reactivity, insulin resistance, hyperlipidemia, and, subsequently, chronic disease. Dietary practices to minimize inflammatory stimuli and CVD risk include regular intakes of fatty fish rich in the eicosapentaenoic and docosahexaenoic acids that compete with the more pervasive membrane fatty acid, arachidonic acid, disrupting the metabolic cascades that stimulate inflammation. Another effective dietary strategy is to consume less arachidonic acid by reducing beef, poultry, fish, and eggs from the diet (e.g., adopting a vegetarian-like diet). Since oxidative stress plays a prominent role in immune system activation, regular ingestion of ample amounts of fruits and vegetables (8+ servings/d) rich in antioxidant compounds, the polyphenols, carotenoids, and vitamin C (e.g., citrus, tomatoes, berries, carrots, and greens), lowers inflammatory mediators and risk for chronic disease. Whole grains, legumes, and nuts have also been demonstrated in clinical trials to effectively reduce inflammatory mediators and risk for CVD. Hence, as proclaimed in antiquity, 'let food be thy medicine and medicine be thy food'.

Links

  • PMC Free PDF
  • PMC Free Full Text
  • Authors+Show Affiliations

    Department of Nutrition, Arizona State University, Mesa AZ 85212.

    Source

    American journal of lifestyle medicine 3:1 Suppl 2009 Jul pg 39S-43S

    Pub Type(s)

    Journal Article

    Language

    eng

    PubMed ID

    20368755

    Citation

    Johnston, Carol. "Functional Foods as Modifiers of Cardiovascular Disease." American Journal of Lifestyle Medicine, vol. 3, no. 1 Suppl, 2009, 39S-43S.
    Johnston C. Functional Foods as Modifiers of Cardiovascular Disease. Am J Lifestyle Med. 2009;3(1 Suppl):39S-43S.
    Johnston, C. (2009). Functional Foods as Modifiers of Cardiovascular Disease. American Journal of Lifestyle Medicine, 3(1 Suppl), 39S-43S.
    Johnston C. Functional Foods as Modifiers of Cardiovascular Disease. Am J Lifestyle Med. 2009;3(1 Suppl):39S-43S. PubMed PMID: 20368755.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Functional Foods as Modifiers of Cardiovascular Disease. A1 - Johnston,Carol, PY - 2010/4/7/entrez PY - 2010/4/7/pubmed PY - 2010/4/7/medline SP - 39S EP - 43S JF - American journal of lifestyle medicine JO - Am J Lifestyle Med VL - 3 IS - 1 Suppl N2 - There is growing consensus that systemic inflammation is at the heart of cardiovascular disease (CVD). Inflammation is a key feature of the immune system, functioning to defend tissue integrity and function. However, chronic stimulation of inflammatory mediators leads to lasting vascular reactivity, insulin resistance, hyperlipidemia, and, subsequently, chronic disease. Dietary practices to minimize inflammatory stimuli and CVD risk include regular intakes of fatty fish rich in the eicosapentaenoic and docosahexaenoic acids that compete with the more pervasive membrane fatty acid, arachidonic acid, disrupting the metabolic cascades that stimulate inflammation. Another effective dietary strategy is to consume less arachidonic acid by reducing beef, poultry, fish, and eggs from the diet (e.g., adopting a vegetarian-like diet). Since oxidative stress plays a prominent role in immune system activation, regular ingestion of ample amounts of fruits and vegetables (8+ servings/d) rich in antioxidant compounds, the polyphenols, carotenoids, and vitamin C (e.g., citrus, tomatoes, berries, carrots, and greens), lowers inflammatory mediators and risk for chronic disease. Whole grains, legumes, and nuts have also been demonstrated in clinical trials to effectively reduce inflammatory mediators and risk for CVD. Hence, as proclaimed in antiquity, 'let food be thy medicine and medicine be thy food'. SN - 1559-8276 UR - https://www.unboundmedicine.com/medline/citation/20368755/full_citation L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20368755/ DB - PRIME DP - Unbound Medicine ER -