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Functional Foods as Modifiers of Cardiovascular Disease.
Am J Lifestyle Med 2009; 3(1 Suppl):39S-43SAJ

Abstract

There is growing consensus that systemic inflammation is at the heart of cardiovascular disease (CVD). Inflammation is a key feature of the immune system, functioning to defend tissue integrity and function. However, chronic stimulation of inflammatory mediators leads to lasting vascular reactivity, insulin resistance, hyperlipidemia, and, subsequently, chronic disease. Dietary practices to minimize inflammatory stimuli and CVD risk include regular intakes of fatty fish rich in the eicosapentaenoic and docosahexaenoic acids that compete with the more pervasive membrane fatty acid, arachidonic acid, disrupting the metabolic cascades that stimulate inflammation. Another effective dietary strategy is to consume less arachidonic acid by reducing beef, poultry, fish, and eggs from the diet (e.g., adopting a vegetarian-like diet). Since oxidative stress plays a prominent role in immune system activation, regular ingestion of ample amounts of fruits and vegetables (8+ servings/d) rich in antioxidant compounds, the polyphenols, carotenoids, and vitamin C (e.g., citrus, tomatoes, berries, carrots, and greens), lowers inflammatory mediators and risk for chronic disease. Whole grains, legumes, and nuts have also been demonstrated in clinical trials to effectively reduce inflammatory mediators and risk for CVD. Hence, as proclaimed in antiquity, 'let food be thy medicine and medicine be thy food'.

Authors+Show Affiliations

Department of Nutrition, Arizona State University, Mesa AZ 85212.

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20368755

Citation

Johnston, Carol. "Functional Foods as Modifiers of Cardiovascular Disease." American Journal of Lifestyle Medicine, vol. 3, no. 1 Suppl, 2009, 39S-43S.
Johnston C. Functional Foods as Modifiers of Cardiovascular Disease. Am J Lifestyle Med. 2009;3(1 Suppl):39S-43S.
Johnston, C. (2009). Functional Foods as Modifiers of Cardiovascular Disease. American Journal of Lifestyle Medicine, 3(1 Suppl), 39S-43S.
Johnston C. Functional Foods as Modifiers of Cardiovascular Disease. Am J Lifestyle Med. 2009;3(1 Suppl):39S-43S. PubMed PMID: 20368755.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Functional Foods as Modifiers of Cardiovascular Disease. A1 - Johnston,Carol, PY - 2010/4/7/entrez PY - 2010/4/7/pubmed PY - 2010/4/7/medline SP - 39S EP - 43S JF - American journal of lifestyle medicine JO - Am J Lifestyle Med VL - 3 IS - 1 Suppl N2 - There is growing consensus that systemic inflammation is at the heart of cardiovascular disease (CVD). Inflammation is a key feature of the immune system, functioning to defend tissue integrity and function. However, chronic stimulation of inflammatory mediators leads to lasting vascular reactivity, insulin resistance, hyperlipidemia, and, subsequently, chronic disease. Dietary practices to minimize inflammatory stimuli and CVD risk include regular intakes of fatty fish rich in the eicosapentaenoic and docosahexaenoic acids that compete with the more pervasive membrane fatty acid, arachidonic acid, disrupting the metabolic cascades that stimulate inflammation. Another effective dietary strategy is to consume less arachidonic acid by reducing beef, poultry, fish, and eggs from the diet (e.g., adopting a vegetarian-like diet). Since oxidative stress plays a prominent role in immune system activation, regular ingestion of ample amounts of fruits and vegetables (8+ servings/d) rich in antioxidant compounds, the polyphenols, carotenoids, and vitamin C (e.g., citrus, tomatoes, berries, carrots, and greens), lowers inflammatory mediators and risk for chronic disease. Whole grains, legumes, and nuts have also been demonstrated in clinical trials to effectively reduce inflammatory mediators and risk for CVD. Hence, as proclaimed in antiquity, 'let food be thy medicine and medicine be thy food'. SN - 1559-8276 UR - https://www.unboundmedicine.com/medline/citation/20368755/full_citation L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/20368755/ DB - PRIME DP - Unbound Medicine ER -