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Oridamycins A and B, anti-Saprolegnia parasitica indolosesquiterpenes isolated from Streptomyces sp. KS84.
J Nat Prod. 2010 Apr 23; 73(4):698-701.JN

Abstract

Oridamycins A (1) and B (2) were isolated from the fermentation broth of Streptomyces sp. strain KS84 as selective anti-Saprolegnia parasitica antibiotics. Their structures were elucidated as pentacyclic indolosesquiterpenes by the combination of NMR and spectroscopic analyses. The absolute configuration of 1 was determined by ROESY analyses after the advanced Mosher analysis. Compound 1 exhibited anti-S. parasitica activity with an MIC value of 3.0 microg/mL, but was much less active against the phytopathogenic fungus Phoma sp. and the yeast Saccharomyces cerevisiae.

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Publisher Full Text (DOI)

Authors+Show Affiliations

Takada K
Laboratory of Microbial Chemistry, College of Pharmaceutical Sciences, Ritsumeikan University, 1-1-1 Noji-Higashi, Kusatsu, Shiga 525-8577, Japan.
Kajiwara H
No affiliation info available
Imamura N
No affiliation info available

MeSH

Anti-Bacterial AgentsAnti-Infective AgentsAntifungal AgentsAscomycotaMicrobial Sensitivity TestsMolecular StructureSaccharomyces cerevisiaeSaprolegniaSesquiterpenesStreptomyces

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20369841

Citation

Takada, Kentaro, et al. "Oridamycins a and B, anti-Saprolegnia Parasitica Indolosesquiterpenes Isolated From Streptomyces Sp. KS84." Journal of Natural Products, vol. 73, no. 4, 2010, pp. 698-701.
Takada K, Kajiwara H, Imamura N. Oridamycins A and B, anti-Saprolegnia parasitica indolosesquiterpenes isolated from Streptomyces sp. KS84. J Nat Prod. 2010;73(4):698-701.
Takada, K., Kajiwara, H., & Imamura, N. (2010). Oridamycins A and B, anti-Saprolegnia parasitica indolosesquiterpenes isolated from Streptomyces sp. KS84. Journal of Natural Products, 73(4), 698-701. https://doi.org/10.1021/np1000522
Takada K, Kajiwara H, Imamura N. Oridamycins a and B, anti-Saprolegnia Parasitica Indolosesquiterpenes Isolated From Streptomyces Sp. KS84. J Nat Prod. 2010 Apr 23;73(4):698-701. PubMed PMID: 20369841.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Oridamycins A and B, anti-Saprolegnia parasitica indolosesquiterpenes isolated from Streptomyces sp. KS84. AU - Takada,Kentaro, AU - Kajiwara,Hisatsugu, AU - Imamura,Nobutaka, PY - 2010/4/8/entrez PY - 2010/4/8/pubmed PY - 2010/6/4/medline SP - 698 EP - 701 JF - Journal of natural products JO - J Nat Prod VL - 73 IS - 4 N2 - Oridamycins A (1) and B (2) were isolated from the fermentation broth of Streptomyces sp. strain KS84 as selective anti-Saprolegnia parasitica antibiotics. Their structures were elucidated as pentacyclic indolosesquiterpenes by the combination of NMR and spectroscopic analyses. The absolute configuration of 1 was determined by ROESY analyses after the advanced Mosher analysis. Compound 1 exhibited anti-S. parasitica activity with an MIC value of 3.0 microg/mL, but was much less active against the phytopathogenic fungus Phoma sp. and the yeast Saccharomyces cerevisiae. SN - 1520-6025 UR - https://www.unboundmedicine.com/medline/citation/20369841/Oridamycins_A_and_B_anti_Saprolegnia_parasitica_indolosesquiterpenes_isolated_from_Streptomyces_sp__KS84_ DB - PRIME DP - Unbound Medicine ER -