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The effect of periodontal treatment on serum leptin, interleukin-6, and C-reactive protein.
J Periodontol. 2010 Aug; 81(8):1118-23.JP

Abstract

BACKGROUND

Previous studies suggest that periodontitis is closely related to obesity and metabolic syndrome. Leptin, a pleiotrophic hormone produced by adipose tissue, has been reported to be related to periodontitis. This study investigates the effects of periodontal treatment on the serum levels of leptin and other cytokines in patients with chronic periodontitis (CP).

METHODS

Serum samples were taken from 33 CP patients (22 non-smokers, 11 smokers) and 18 healthy subjects. The serum leptin, adiponectin, tumor necrosis factor-alpha, interleukin (IL)-6, and C-reactive protein (CRP) levels were measured before and after non-surgical periodontal treatment.

RESULTS

Significant differences between healthy and CP patients were found in serum leptin, IL-6, and CRP levels (P = 0.0018, P = 0.0064, and P = 0.0095, respectively). The serum leptin level was associated with mean probing depth, mean clinical attachment level, mean alveolar bone loss, and body mass index. There were significant associations between serum leptin levels and IL-6 and CRP levels. After non-surgical periodontal treatment, serum leptin, IL-6, and CRP levels were significantly decreased (mean +/- SD before and after, P value, respectively: leptin, 8.02 +/- 5.5, 7.10 +/- 4.4, P = 0.015; IL-6, 1.73 +/- 1.02, 1.36 +/- 0.73, P = 0.048; and CRP, 802.0 +/- 1065, 491.2 +/- 479.3, P = 0.047).

CONCLUSIONS

Periodontal treatment is effective in reducing serum leptin, IL-6, and CRP levels. The results suggest that leptin, IL-6, and CRP could be mediating factors that connect metabolic syndrome and periodontitis.

Authors+Show Affiliations

Division of Periodontology, Niigata University Graduate School of Medical and Dental Sciences, Chuo-ku, Niigata, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20370420

Citation

Shimada, Yasuko, et al. "The Effect of Periodontal Treatment On Serum Leptin, Interleukin-6, and C-reactive Protein." Journal of Periodontology, vol. 81, no. 8, 2010, pp. 1118-23.
Shimada Y, Komatsu Y, Ikezawa-Suzuki I, et al. The effect of periodontal treatment on serum leptin, interleukin-6, and C-reactive protein. J Periodontol. 2010;81(8):1118-23.
Shimada, Y., Komatsu, Y., Ikezawa-Suzuki, I., Tai, H., Sugita, N., & Yoshie, H. (2010). The effect of periodontal treatment on serum leptin, interleukin-6, and C-reactive protein. Journal of Periodontology, 81(8), 1118-23. https://doi.org/10.1902/jop.2010.090741
Shimada Y, et al. The Effect of Periodontal Treatment On Serum Leptin, Interleukin-6, and C-reactive Protein. J Periodontol. 2010;81(8):1118-23. PubMed PMID: 20370420.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of periodontal treatment on serum leptin, interleukin-6, and C-reactive protein. AU - Shimada,Yasuko, AU - Komatsu,Yasutaka, AU - Ikezawa-Suzuki,Ikuyo, AU - Tai,Hideaki, AU - Sugita,Noriko, AU - Yoshie,Hiromasa, PY - 2010/4/8/entrez PY - 2010/4/8/pubmed PY - 2010/12/14/medline SP - 1118 EP - 23 JF - Journal of periodontology JO - J. Periodontol. VL - 81 IS - 8 N2 - BACKGROUND: Previous studies suggest that periodontitis is closely related to obesity and metabolic syndrome. Leptin, a pleiotrophic hormone produced by adipose tissue, has been reported to be related to periodontitis. This study investigates the effects of periodontal treatment on the serum levels of leptin and other cytokines in patients with chronic periodontitis (CP). METHODS: Serum samples were taken from 33 CP patients (22 non-smokers, 11 smokers) and 18 healthy subjects. The serum leptin, adiponectin, tumor necrosis factor-alpha, interleukin (IL)-6, and C-reactive protein (CRP) levels were measured before and after non-surgical periodontal treatment. RESULTS: Significant differences between healthy and CP patients were found in serum leptin, IL-6, and CRP levels (P = 0.0018, P = 0.0064, and P = 0.0095, respectively). The serum leptin level was associated with mean probing depth, mean clinical attachment level, mean alveolar bone loss, and body mass index. There were significant associations between serum leptin levels and IL-6 and CRP levels. After non-surgical periodontal treatment, serum leptin, IL-6, and CRP levels were significantly decreased (mean +/- SD before and after, P value, respectively: leptin, 8.02 +/- 5.5, 7.10 +/- 4.4, P = 0.015; IL-6, 1.73 +/- 1.02, 1.36 +/- 0.73, P = 0.048; and CRP, 802.0 +/- 1065, 491.2 +/- 479.3, P = 0.047). CONCLUSIONS: Periodontal treatment is effective in reducing serum leptin, IL-6, and CRP levels. The results suggest that leptin, IL-6, and CRP could be mediating factors that connect metabolic syndrome and periodontitis. SN - 1943-3670 UR - https://www.unboundmedicine.com/medline/citation/20370420/The_effect_of_periodontal_treatment_on_serum_leptin_interleukin_6_and_C_reactive_protein_ L2 - https://doi.org/10.1902/jop.2010.090741 DB - PRIME DP - Unbound Medicine ER -