Tags

Type your tag names separated by a space and hit enter

Attenuation of oxidative stress and alteration of hepatic tissue ultrastructure by D-pinitol in streptozotocin-induced diabetic rats.
Free Radic Res. 2010 Jun; 44(6):668-78.FR

Abstract

The present study was aimed to investigate the effect of D-pinitol on hyperglycaemia mediated oxidative stress by analysing the hepatic antioxidant competence, pro-inflammatory cytokines and ultrastructural changes in liver tissues of streptozotocin-induced diabetic rats. Oral administration of D-pinitol (50 mg/kg b.w.) resulted in significant (p < 0.05) attenuation in blood glucose, glycosylated haemoglobin and pro-inflammatory markers such as TNF-alpha, IL-1beta, IL-6, NF-kappaB p65 unit and NO and significant (p < 0.05) elevation in the plasma insulin level. In addition, D-pinitol instigated a significant escalation in the levels of hepatic tissue non-enzymatic antioxidants and the activities enzymatic antioxidants of diabetic rats with significant (p < 0.05) decrease in lipid peroxides and hydroperoxides formation, thus demonstrating the protective role of D-pinitol on the hepatic tissues from oxidative stress-induced liver damage. These biochemical observations were complemented by histological and ultrastructural examination of liver section. Thus, the present study demonstrates the hepatoprotective nature of D-pinitol by attenuating hyperglycaemia-mediated pro-inflammatory cytokines and oxidative stress.

Authors+Show Affiliations

Department of Biochemistry, University of Madras, Guindy Campus, Chennai 600 025, Tamilnadu, India.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20370563

Citation

Sivakumar, Selvaraj, et al. "Attenuation of Oxidative Stress and Alteration of Hepatic Tissue Ultrastructure By D-pinitol in Streptozotocin-induced Diabetic Rats." Free Radical Research, vol. 44, no. 6, 2010, pp. 668-78.
Sivakumar S, Palsamy P, Subramanian SP. Attenuation of oxidative stress and alteration of hepatic tissue ultrastructure by D-pinitol in streptozotocin-induced diabetic rats. Free Radic Res. 2010;44(6):668-78.
Sivakumar, S., Palsamy, P., & Subramanian, S. P. (2010). Attenuation of oxidative stress and alteration of hepatic tissue ultrastructure by D-pinitol in streptozotocin-induced diabetic rats. Free Radical Research, 44(6), 668-78. https://doi.org/10.3109/10715761003733901
Sivakumar S, Palsamy P, Subramanian SP. Attenuation of Oxidative Stress and Alteration of Hepatic Tissue Ultrastructure By D-pinitol in Streptozotocin-induced Diabetic Rats. Free Radic Res. 2010;44(6):668-78. PubMed PMID: 20370563.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Attenuation of oxidative stress and alteration of hepatic tissue ultrastructure by D-pinitol in streptozotocin-induced diabetic rats. AU - Sivakumar,Selvaraj, AU - Palsamy,Periyasamy, AU - Subramanian,Sorimuthu Pillai, PY - 2010/4/8/entrez PY - 2010/4/8/pubmed PY - 2010/8/14/medline SP - 668 EP - 78 JF - Free radical research JO - Free Radic Res VL - 44 IS - 6 N2 - The present study was aimed to investigate the effect of D-pinitol on hyperglycaemia mediated oxidative stress by analysing the hepatic antioxidant competence, pro-inflammatory cytokines and ultrastructural changes in liver tissues of streptozotocin-induced diabetic rats. Oral administration of D-pinitol (50 mg/kg b.w.) resulted in significant (p < 0.05) attenuation in blood glucose, glycosylated haemoglobin and pro-inflammatory markers such as TNF-alpha, IL-1beta, IL-6, NF-kappaB p65 unit and NO and significant (p < 0.05) elevation in the plasma insulin level. In addition, D-pinitol instigated a significant escalation in the levels of hepatic tissue non-enzymatic antioxidants and the activities enzymatic antioxidants of diabetic rats with significant (p < 0.05) decrease in lipid peroxides and hydroperoxides formation, thus demonstrating the protective role of D-pinitol on the hepatic tissues from oxidative stress-induced liver damage. These biochemical observations were complemented by histological and ultrastructural examination of liver section. Thus, the present study demonstrates the hepatoprotective nature of D-pinitol by attenuating hyperglycaemia-mediated pro-inflammatory cytokines and oxidative stress. SN - 1029-2470 UR - https://www.unboundmedicine.com/medline/citation/20370563/Attenuation_of_oxidative_stress_and_alteration_of_hepatic_tissue_ultrastructure_by_D_pinitol_in_streptozotocin_induced_diabetic_rats_ L2 - https://www.tandfonline.com/doi/full/10.3109/10715761003733901 DB - PRIME DP - Unbound Medicine ER -