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Spectrum of metabolic dysfunction in relationship with hyperandrogenemia in obese adolescent girls with polycystic ovary syndrome.
Eur J Endocrinol. 2010 Jun; 162(6):1093-9.EJ

Abstract

OBJECTIVE

Polycystic ovary syndrome (PCOS) in adult women is associated with increased risk of metabolic syndrome (MS) and atherosclerosis. We evaluated the spectrum of metabolic dysfunction in relationship with hyperandrogenemia (HA) in adolescent girls with PCOS.

MATERIALS AND METHODS

Ovulatory function, acne, hirsutism (HS), body mass index (BMI), body composition, fasting lipids, glucose, insulin, free testosterone (FT), high-sensitivity C-reactive protein (hs-CRP), and HbA1c were evaluated in 103 girls. The homeostatic assessment model equations (HOMA-IR and HOMA-%B) were used for determination of insulin resistance and beta-cell function respectively.

RESULTS

The oligo-ovulation (Oligo)+HA+HS (n=44), Oligo+HA (n=28), and Oligo+HS (n=31) phenotypes had similar BMI. However, hyperandrogenemic phenotypes had higher prevalence of acanthosis nigricans (AN) and acne (P<0.01) and higher insulin, HOMA-IR, HOMA-%B, HbA1c, and hs-CRP levels than Oligo+HS group (P<0.01). Serum FT was correlated with HOMA-IR (r=0.38, P<0.01), HOMA-%B (r=0.49, P<0.01), hs-CRP (r=0.42, P<0.01), AN (r=0.39, P<0.01), and HbA1c (r=0.27, P<0.01). Furthermore, 34% of girls met diagnostic criteria for MS displaying higher BMI, FT, HOMA-%B, HOMA-IR, hs-CRP, and HbA1c than subjects without MS (P<0.01). Using combined HOMA-IR>or=4.0 and hs-CRP>3.0 cut-off values, 71.4% of MS versus 23.5% non-MS group were considered at risk of diabetes and atherosclerosis (P<0.0001).

CONCLUSIONS

Hyperandrogenemic PCOS phenotypes have greatest degree of insulin resistance and inflammation. The use of insulin resistance and inflammatory markers may help identify adolescent girls with PCOS at risk of cardiometabolic syndrome.

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Authors+Show Affiliations

Alemzadeh R
Section of Pediatric Endocrinology and Metabolism, Department of Pediatrics, Medical College of Wisconsin, Milwaukee, Wisconsin 53226, USA. ralemzad@mcw.edu
Kichler J
No affiliation info available
Calhoun M
No affiliation info available

MeSH

AdolescentAnalysis of VarianceBlood GlucoseBlood PressureBody CompositionBody Mass IndexC-Reactive ProteinChi-Square DistributionFemaleHirsutismHumansHyperandrogenismInsulinInsulin ResistanceMetabolic SyndromeObesityPolycystic Ovary SyndromeRisk FactorsSurveys and QuestionnairesTestosteroneYoung Adult

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20371657

Citation

Alemzadeh, Ramin, et al. "Spectrum of Metabolic Dysfunction in Relationship With Hyperandrogenemia in Obese Adolescent Girls With Polycystic Ovary Syndrome." European Journal of Endocrinology, vol. 162, no. 6, 2010, pp. 1093-9.
Alemzadeh R, Kichler J, Calhoun M. Spectrum of metabolic dysfunction in relationship with hyperandrogenemia in obese adolescent girls with polycystic ovary syndrome. Eur J Endocrinol. 2010;162(6):1093-9.
Alemzadeh, R., Kichler, J., & Calhoun, M. (2010). Spectrum of metabolic dysfunction in relationship with hyperandrogenemia in obese adolescent girls with polycystic ovary syndrome. European Journal of Endocrinology, 162(6), 1093-9. https://doi.org/10.1530/EJE-10-0205
Alemzadeh R, Kichler J, Calhoun M. Spectrum of Metabolic Dysfunction in Relationship With Hyperandrogenemia in Obese Adolescent Girls With Polycystic Ovary Syndrome. Eur J Endocrinol. 2010;162(6):1093-9. PubMed PMID: 20371657.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Spectrum of metabolic dysfunction in relationship with hyperandrogenemia in obese adolescent girls with polycystic ovary syndrome. AU - Alemzadeh,Ramin, AU - Kichler,Jessica, AU - Calhoun,Mariaelena, Y1 - 2010/04/06/ PY - 2010/4/8/entrez PY - 2010/4/8/pubmed PY - 2010/6/29/medline SP - 1093 EP - 9 JF - European journal of endocrinology JO - Eur J Endocrinol VL - 162 IS - 6 N2 - OBJECTIVE: Polycystic ovary syndrome (PCOS) in adult women is associated with increased risk of metabolic syndrome (MS) and atherosclerosis. We evaluated the spectrum of metabolic dysfunction in relationship with hyperandrogenemia (HA) in adolescent girls with PCOS. MATERIALS AND METHODS: Ovulatory function, acne, hirsutism (HS), body mass index (BMI), body composition, fasting lipids, glucose, insulin, free testosterone (FT), high-sensitivity C-reactive protein (hs-CRP), and HbA1c were evaluated in 103 girls. The homeostatic assessment model equations (HOMA-IR and HOMA-%B) were used for determination of insulin resistance and beta-cell function respectively. RESULTS: The oligo-ovulation (Oligo)+HA+HS (n=44), Oligo+HA (n=28), and Oligo+HS (n=31) phenotypes had similar BMI. However, hyperandrogenemic phenotypes had higher prevalence of acanthosis nigricans (AN) and acne (P<0.01) and higher insulin, HOMA-IR, HOMA-%B, HbA1c, and hs-CRP levels than Oligo+HS group (P<0.01). Serum FT was correlated with HOMA-IR (r=0.38, P<0.01), HOMA-%B (r=0.49, P<0.01), hs-CRP (r=0.42, P<0.01), AN (r=0.39, P<0.01), and HbA1c (r=0.27, P<0.01). Furthermore, 34% of girls met diagnostic criteria for MS displaying higher BMI, FT, HOMA-%B, HOMA-IR, hs-CRP, and HbA1c than subjects without MS (P<0.01). Using combined HOMA-IR>or=4.0 and hs-CRP>3.0 cut-off values, 71.4% of MS versus 23.5% non-MS group were considered at risk of diabetes and atherosclerosis (P<0.0001). CONCLUSIONS: Hyperandrogenemic PCOS phenotypes have greatest degree of insulin resistance and inflammation. The use of insulin resistance and inflammatory markers may help identify adolescent girls with PCOS at risk of cardiometabolic syndrome. SN - 1479-683X UR - https://www.unboundmedicine.com/medline/citation/20371657/Spectrum_of_metabolic_dysfunction_in_relationship_with_hyperandrogenemia_in_obese_adolescent_girls_with_polycystic_ovary_syndrome_ L2 - https://eje.bioscientifica.com/doi/10.1530/EJE-10-0205 DB - PRIME DP - Unbound Medicine ER -