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Evaluating a bacterial hypothesis in IBS using a modification of Koch's postulates: part 1.
Am J Gastroenterol. 2010 Apr; 105(4):718-21.AJ

Abstract

It has recently been suggested that irritable bowel syndrome (IBS) symptoms are due partly to small intestinal bacterial overgrowth (SIBO). This "SIBO hypothesis" has led to the use of antibiotics to treat IBS. Koch's postulates have long been used to establish bacteria as a cause of diseases such as tuberculosis. Because SIBO is not a single organism, we use modified Koch's postulates to argue for antibiotics and an SIBO hypothesis in the pathophysiology of IBS. We show that there is evidence for SIBO, that it is culturable, that antibiotic elimination of the bacteria improves subjects clinically, and that when the bacteria return, the symptoms return. On the basis of proof of a bacterial cause of IBS, antibiotics may be a good choice of therapy.

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Authors+Show Affiliations

Pimentel M
GI Motility Program, Cedars-Sinai Medical Center, Los Angeles, California, USA. pimentelm@cshs.org

MeSH

Anti-Bacterial AgentsBacteriaBacterial InfectionsBreath TestsHumansIntestine, SmallIrritable Bowel Syndrome

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20372119

Citation

Pimentel, Mark. "Evaluating a Bacterial Hypothesis in IBS Using a Modification of Koch's Postulates: Part 1." The American Journal of Gastroenterology, vol. 105, no. 4, 2010, pp. 718-21.
Pimentel M. Evaluating a bacterial hypothesis in IBS using a modification of Koch's postulates: part 1. Am J Gastroenterol. 2010;105(4):718-21.
Pimentel, M. (2010). Evaluating a bacterial hypothesis in IBS using a modification of Koch's postulates: part 1. The American Journal of Gastroenterology, 105(4), 718-21. https://doi.org/10.1038/ajg.2009.678
Pimentel M. Evaluating a Bacterial Hypothesis in IBS Using a Modification of Koch's Postulates: Part 1. Am J Gastroenterol. 2010;105(4):718-21. PubMed PMID: 20372119.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluating a bacterial hypothesis in IBS using a modification of Koch's postulates: part 1. A1 - Pimentel,Mark, PY - 2010/4/8/entrez PY - 2010/4/8/pubmed PY - 2010/5/7/medline SP - 718 EP - 21 JF - The American journal of gastroenterology JO - Am J Gastroenterol VL - 105 IS - 4 N2 - It has recently been suggested that irritable bowel syndrome (IBS) symptoms are due partly to small intestinal bacterial overgrowth (SIBO). This "SIBO hypothesis" has led to the use of antibiotics to treat IBS. Koch's postulates have long been used to establish bacteria as a cause of diseases such as tuberculosis. Because SIBO is not a single organism, we use modified Koch's postulates to argue for antibiotics and an SIBO hypothesis in the pathophysiology of IBS. We show that there is evidence for SIBO, that it is culturable, that antibiotic elimination of the bacteria improves subjects clinically, and that when the bacteria return, the symptoms return. On the basis of proof of a bacterial cause of IBS, antibiotics may be a good choice of therapy. SN - 1572-0241 UR - https://www.unboundmedicine.com/medline/citation/20372119/Evaluating_a_bacterial_hypothesis_in_IBS_using_a_modification_of_Koch's_postulates:_part_1_ L2 - https://Insights.ovid.com/pubmed?pmid=20372119 DB - PRIME DP - Unbound Medicine ER -