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Pre- and post-therapy nodal status equally affects survival of patients with oesophageal squamous cell carcinoma receiving preoperative chemoradiation.
Oncol Rep. 2010 May; 23(5):1331-7.OR

Abstract

Patients with deeply invading (T3-T4) oesophageal cancers usually receive chemoradiotherapy with or without surgery. However, the prognostic significance of pre-therapy and post-therapy lymph node (LN) status remains unclear. We studied 195 patients who received chemoradiotherapy for deeply invading oesophageal cancers (T3-4, N0-1, M0). Of these, 105 patients underwent surgery while 90 were treated by chemoradiotherapy alone. Of the 105 surgically treated patients, overall survival was significantly better in cN0 patients than in cN1 (3-year survival rate, 65.3 vs. 25.8%, P=0.0014). This difference was similarly observed in 90 patients who received chemoradiotherapy alone. Patient survival differed significantly among patients with no positive LN, 1 positive LN and 2-4 positive LN (3-year survival rate, 57.1 vs. 40.5 vs. 17.6%, P<0.0001). However, there was no significant difference in survival between patients with 2-4 positive LN and > or =5 positive LN. Multivariate analysis identified pre-therapy LN status and the number of involved LNs as the most important independent prognostic factors prior to histopathological tumour regression. In conclusion, pre-therapy LN status and the number of post-therapy involved LNs equally affect survival of patients who receive neo-adjuvant chemoradiotherapy. Control of systemic metastasis is required, based on pre- and post-therapy LN status.

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Authors+Show Affiliations

Miyata H
Department of Gastroenterological Surgery, Graduate School of Medicine, Osaka University, Osaka 565-0871, Japan. hmiyata@gesurg.med.osaka-u.ac.jp
Yamasaki M
No affiliation info available
Takiguchi S
No affiliation info available
Nakajima K
No affiliation info available
Fujiwara Y
No affiliation info available
Mori M
No affiliation info available
Doki Y
No affiliation info available

MeSH

AdultAgedAged, 80 and overAntineoplastic Combined Chemotherapy ProtocolsCarcinoma, Squamous CellChemotherapy, AdjuvantCisplatinEsophageal NeoplasmsEsophagectomyFemaleFluorouracilHumansKaplan-Meier EstimateLymph Node ExcisionLymphatic MetastasisMaleMiddle AgedNeoadjuvant TherapyNeoplasm InvasivenessNeoplasm StagingProportional Hazards ModelsRadiotherapy, AdjuvantRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTreatment Outcome

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20372848

Citation

Miyata, Hiroshi, et al. "Pre- and Post-therapy Nodal Status Equally Affects Survival of Patients With Oesophageal Squamous Cell Carcinoma Receiving Preoperative Chemoradiation." Oncology Reports, vol. 23, no. 5, 2010, pp. 1331-7.
Miyata H, Yamasaki M, Takiguchi S, et al. Pre- and post-therapy nodal status equally affects survival of patients with oesophageal squamous cell carcinoma receiving preoperative chemoradiation. Oncol Rep. 2010;23(5):1331-7.
Miyata, H., Yamasaki, M., Takiguchi, S., Nakajima, K., Fujiwara, Y., Mori, M., & Doki, Y. (2010). Pre- and post-therapy nodal status equally affects survival of patients with oesophageal squamous cell carcinoma receiving preoperative chemoradiation. Oncology Reports, 23(5), 1331-7.
Miyata H, et al. Pre- and Post-therapy Nodal Status Equally Affects Survival of Patients With Oesophageal Squamous Cell Carcinoma Receiving Preoperative Chemoradiation. Oncol Rep. 2010;23(5):1331-7. PubMed PMID: 20372848.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Pre- and post-therapy nodal status equally affects survival of patients with oesophageal squamous cell carcinoma receiving preoperative chemoradiation. AU - Miyata,Hiroshi, AU - Yamasaki,Makoto, AU - Takiguchi,Shuji, AU - Nakajima,Kiyokazu, AU - Fujiwara,Yoshiyuki, AU - Mori,Masaki, AU - Doki,Yuichiro, PY - 2010/4/8/entrez PY - 2010/4/8/pubmed PY - 2010/7/14/medline SP - 1331 EP - 7 JF - Oncology reports JO - Oncol Rep VL - 23 IS - 5 N2 - Patients with deeply invading (T3-T4) oesophageal cancers usually receive chemoradiotherapy with or without surgery. However, the prognostic significance of pre-therapy and post-therapy lymph node (LN) status remains unclear. We studied 195 patients who received chemoradiotherapy for deeply invading oesophageal cancers (T3-4, N0-1, M0). Of these, 105 patients underwent surgery while 90 were treated by chemoradiotherapy alone. Of the 105 surgically treated patients, overall survival was significantly better in cN0 patients than in cN1 (3-year survival rate, 65.3 vs. 25.8%, P=0.0014). This difference was similarly observed in 90 patients who received chemoradiotherapy alone. Patient survival differed significantly among patients with no positive LN, 1 positive LN and 2-4 positive LN (3-year survival rate, 57.1 vs. 40.5 vs. 17.6%, P<0.0001). However, there was no significant difference in survival between patients with 2-4 positive LN and > or =5 positive LN. Multivariate analysis identified pre-therapy LN status and the number of involved LNs as the most important independent prognostic factors prior to histopathological tumour regression. In conclusion, pre-therapy LN status and the number of post-therapy involved LNs equally affect survival of patients who receive neo-adjuvant chemoradiotherapy. Control of systemic metastasis is required, based on pre- and post-therapy LN status. SN - 1791-2431 UR - https://www.unboundmedicine.com/medline/citation/20372848/Pre__and_post_therapy_nodal_status_equally_affects_survival_of_patients_with_oesophageal_squamous_cell_carcinoma_receiving_preoperative_chemoradiation_ L2 - http://www.spandidos-publications.com/or/23/5/1331 DB - PRIME DP - Unbound Medicine ER -