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Twelve years experience with radical hysterectomy and pelvic lymphadenectomy in early stage cervical cancer.
J Obstet Gynaecol. 2010 Apr; 30(3):294-8.JO

Abstract

The objective of this study was to evaluate the outcome, prognostic factors and complications of early stage cervical cancer patients treated with radical hysterectomy and pelvic lymphadenectomy (RHPL). The medical records of cervical cancer patients undergoing RHPL at Chiang Mai University Hospital over 12 years, between January 1995 and December 2006 were reviewed. There were 1,253 patients in the study period. The mean age was 44 years of age. Of these, 26.9% had prior diagnostic conisation. The maximum tumour size was 8 cm. The most common histology was squamous cell carcinoma (67%) followed by adenocarcinoma (23%). The distribution of FIGO staging was: stage IA 8.7%; stage IB 15.8%; stage IB1 61%; stage IB2 6.2%; and stage IIA 8.5%. Pelvic nodes, parametrial and vaginal margin involvement were detected in 15.9%, 10.7% and 3.8% of the patients, respectively. A total of 66.5% of patients underwent RHPL without adjuvant treatment; 12.1% received neoadjuvant chemotherapy. The estimated 10-year recurrence-free survival rate was 90%. Stage IB2/IIA, non-squamous cell carcinoma, nodal involvement and positive vaginal margins were independent, significant, poor prognostic factors. The most common long-term complication was lymphoedema. It was concluded that early stage cervical cancer patients treated with RHPL have long-term favourable outcome with minimal morbidity. Stage IB2 and IIA, non-squamous cell carcinoma, nodal and vaginal involvement were independent adverse prognostic factors.

Authors+Show Affiliations

Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Faculty of Medicine, Chiang Mai University, Chiang Mai, Thailand. psuprase@mail.med.cmu.ac.thNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20373935

Citation

Suprasert, P, et al. "Twelve Years Experience With Radical Hysterectomy and Pelvic Lymphadenectomy in Early Stage Cervical Cancer." Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology, vol. 30, no. 3, 2010, pp. 294-8.
Suprasert P, Srisomboon J, Charoenkwan K, et al. Twelve years experience with radical hysterectomy and pelvic lymphadenectomy in early stage cervical cancer. J Obstet Gynaecol. 2010;30(3):294-8.
Suprasert, P., Srisomboon, J., Charoenkwan, K., Siriaree, S., Cheewakriangkrai, C., Kietpeerakool, C., Phongnarisorn, C., & Sae-Teng, J. (2010). Twelve years experience with radical hysterectomy and pelvic lymphadenectomy in early stage cervical cancer. Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology, 30(3), 294-8. https://doi.org/10.3109/01443610903585192
Suprasert P, et al. Twelve Years Experience With Radical Hysterectomy and Pelvic Lymphadenectomy in Early Stage Cervical Cancer. J Obstet Gynaecol. 2010;30(3):294-8. PubMed PMID: 20373935.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Twelve years experience with radical hysterectomy and pelvic lymphadenectomy in early stage cervical cancer. AU - Suprasert,P, AU - Srisomboon,J, AU - Charoenkwan,K, AU - Siriaree,S, AU - Cheewakriangkrai,C, AU - Kietpeerakool,C, AU - Phongnarisorn,C, AU - Sae-Teng,J, PY - 2010/4/9/entrez PY - 2010/4/9/pubmed PY - 2010/7/8/medline SP - 294 EP - 8 JF - Journal of obstetrics and gynaecology : the journal of the Institute of Obstetrics and Gynaecology JO - J Obstet Gynaecol VL - 30 IS - 3 N2 - The objective of this study was to evaluate the outcome, prognostic factors and complications of early stage cervical cancer patients treated with radical hysterectomy and pelvic lymphadenectomy (RHPL). The medical records of cervical cancer patients undergoing RHPL at Chiang Mai University Hospital over 12 years, between January 1995 and December 2006 were reviewed. There were 1,253 patients in the study period. The mean age was 44 years of age. Of these, 26.9% had prior diagnostic conisation. The maximum tumour size was 8 cm. The most common histology was squamous cell carcinoma (67%) followed by adenocarcinoma (23%). The distribution of FIGO staging was: stage IA 8.7%; stage IB 15.8%; stage IB1 61%; stage IB2 6.2%; and stage IIA 8.5%. Pelvic nodes, parametrial and vaginal margin involvement were detected in 15.9%, 10.7% and 3.8% of the patients, respectively. A total of 66.5% of patients underwent RHPL without adjuvant treatment; 12.1% received neoadjuvant chemotherapy. The estimated 10-year recurrence-free survival rate was 90%. Stage IB2/IIA, non-squamous cell carcinoma, nodal involvement and positive vaginal margins were independent, significant, poor prognostic factors. The most common long-term complication was lymphoedema. It was concluded that early stage cervical cancer patients treated with RHPL have long-term favourable outcome with minimal morbidity. Stage IB2 and IIA, non-squamous cell carcinoma, nodal and vaginal involvement were independent adverse prognostic factors. SN - 1364-6893 UR - https://www.unboundmedicine.com/medline/citation/20373935/Twelve_years_experience_with_radical_hysterectomy_and_pelvic_lymphadenectomy_in_early_stage_cervical_cancer_ L2 - http://www.tandfonline.com/doi/full/10.3109/01443610903585192 DB - PRIME DP - Unbound Medicine ER -