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Circadian activity rhythms and mortality: the study of osteoporotic fractures.
J Am Geriatr Soc. 2010 Feb; 58(2):282-91.JA

Abstract

OBJECTIVES

To determine whether circadian activity rhythms are associated with mortality in community-dwelling older women.

DESIGN

Prospective study of mortality.

SETTING

A cohort study of health and aging.

PARTICIPANTS

Three thousand twenty-seven community-dwelling women from the Study of Osteoporotic Fractures cohort (mean age 84).

MEASUREMENTS

Activity data were collected using wrist actigraphy for a minimum of three 24-hour periods, and circadian activity rhythms were computed. Parameters of interest included height of activity peak (amplitude), midline estimating statistic of rhythm (mesor), strength of activity rhythm (robustness), and time of peak activity (acrophase). Vital status, with cause of death adjudicated through death certificates, was prospectively ascertained.

RESULTS

Over an average of 4.1 years of follow-up, there were 444 (14.7%) deaths. There was an inverse association between peak activity height and all-cause mortality rates, with higher mortality rates observed in the lowest activity quartile (hazard ratio (HR)=2.18, 95% confidence interval (CI)=1.63-2.92) than in the highest quartile after adjusting for age, clinic site, race, body mass index, cognitive function, exercise, instrumental activity of daily living impairments, depression, medications, alcohol, smoking, self-reported health status, married status, and comorbidities. A greater risk of mortality from all causes was observed for those in the lowest quartiles of mesor (HR=1.71, 95% CI=1.29-2.27) and rhythm robustness (HR=1.97, 95% CI=1.50-2.60) than for those in the highest quartiles. Greater mortality from cancer (HR=2.09, 95% CI=1.04-4.22) and stroke (HR=2.64, 95% CI=1.11-6.30) was observed for later peak activity (after 4:33 p.m.; >1.5 SD from mean) than for the mean peak range (2:50-4:33 p.m.).

CONCLUSION

Older women with weak circadian activity rhythms have higher mortality risk. If confirmed in other cohorts, studies will be needed to test whether interventions (e.g., physical activity, bright light exposure) that regulate circadian activity rhythms will improve health outcomes in older adults.

Authors+Show Affiliations

California Pacific Medical Center Research Institute, San Francisco Coordinating Center, UCSF, 185 Berry Street, Lobby 4, Suite 5700, San Francisco, CA 94107, USA. gtranah@psg.ucsf.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Multicenter Study
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20374404

Citation

Tranah, Gregory J., et al. "Circadian Activity Rhythms and Mortality: the Study of Osteoporotic Fractures." Journal of the American Geriatrics Society, vol. 58, no. 2, 2010, pp. 282-91.
Tranah GJ, Blackwell T, Ancoli-Israel S, et al. Circadian activity rhythms and mortality: the study of osteoporotic fractures. J Am Geriatr Soc. 2010;58(2):282-91.
Tranah, G. J., Blackwell, T., Ancoli-Israel, S., Paudel, M. L., Ensrud, K. E., Cauley, J. A., Redline, S., Hillier, T. A., Cummings, S. R., & Stone, K. L. (2010). Circadian activity rhythms and mortality: the study of osteoporotic fractures. Journal of the American Geriatrics Society, 58(2), 282-91. https://doi.org/10.1111/j.1532-5415.2009.02674.x
Tranah GJ, et al. Circadian Activity Rhythms and Mortality: the Study of Osteoporotic Fractures. J Am Geriatr Soc. 2010;58(2):282-91. PubMed PMID: 20374404.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Circadian activity rhythms and mortality: the study of osteoporotic fractures. AU - Tranah,Gregory J, AU - Blackwell,Terri, AU - Ancoli-Israel,Sonia, AU - Paudel,Misti L, AU - Ensrud,Kristine E, AU - Cauley,Jane A, AU - Redline,Susan, AU - Hillier,Teresa A, AU - Cummings,Steven R, AU - Stone,Katie L, AU - ,, Y1 - 2010/01/26/ PY - 2010/4/9/entrez PY - 2010/4/9/pubmed PY - 2010/4/23/medline SP - 282 EP - 91 JF - Journal of the American Geriatrics Society JO - J Am Geriatr Soc VL - 58 IS - 2 N2 - OBJECTIVES: To determine whether circadian activity rhythms are associated with mortality in community-dwelling older women. DESIGN: Prospective study of mortality. SETTING: A cohort study of health and aging. PARTICIPANTS: Three thousand twenty-seven community-dwelling women from the Study of Osteoporotic Fractures cohort (mean age 84). MEASUREMENTS: Activity data were collected using wrist actigraphy for a minimum of three 24-hour periods, and circadian activity rhythms were computed. Parameters of interest included height of activity peak (amplitude), midline estimating statistic of rhythm (mesor), strength of activity rhythm (robustness), and time of peak activity (acrophase). Vital status, with cause of death adjudicated through death certificates, was prospectively ascertained. RESULTS: Over an average of 4.1 years of follow-up, there were 444 (14.7%) deaths. There was an inverse association between peak activity height and all-cause mortality rates, with higher mortality rates observed in the lowest activity quartile (hazard ratio (HR)=2.18, 95% confidence interval (CI)=1.63-2.92) than in the highest quartile after adjusting for age, clinic site, race, body mass index, cognitive function, exercise, instrumental activity of daily living impairments, depression, medications, alcohol, smoking, self-reported health status, married status, and comorbidities. A greater risk of mortality from all causes was observed for those in the lowest quartiles of mesor (HR=1.71, 95% CI=1.29-2.27) and rhythm robustness (HR=1.97, 95% CI=1.50-2.60) than for those in the highest quartiles. Greater mortality from cancer (HR=2.09, 95% CI=1.04-4.22) and stroke (HR=2.64, 95% CI=1.11-6.30) was observed for later peak activity (after 4:33 p.m.; >1.5 SD from mean) than for the mean peak range (2:50-4:33 p.m.). CONCLUSION: Older women with weak circadian activity rhythms have higher mortality risk. If confirmed in other cohorts, studies will be needed to test whether interventions (e.g., physical activity, bright light exposure) that regulate circadian activity rhythms will improve health outcomes in older adults. SN - 1532-5415 UR - https://www.unboundmedicine.com/medline/citation/20374404/Circadian_activity_rhythms_and_mortality:_the_study_of_osteoporotic_fractures_ L2 - https://doi.org/10.1111/j.1532-5415.2009.02674.x DB - PRIME DP - Unbound Medicine ER -