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MAOA T941G polymorphism and the time course of emotional recovery following unpleasant pictures.
Psychophysiology. 2010 Sep; 47(5):857-62.P

Abstract

Difficulty down-regulating negative affect has been linked with anxiety and depression. In addition, recent studies have identified specific polymorphisms of the MAOA gene related to affective psychopathology. Here we examined whether genetic variation in MAOA was associated with the time course of responses to affective stimuli. Emotion-modulation of the startle blink response was measured during and after affective pictures. Women with the G/G genotype of the MAOA T941G single nucleotide polymorphism showed sustained reactivity to unpleasant stimuli, as evidenced by continued blink potentiation during the picture-offset period. These data suggest that the MAOA T941G polymorphism, which has been previously linked with mood disorders, is associated with a maladaptive pattern of affective responding in women.

Authors+Show Affiliations

Department of Psychology, University of Wisconsin-Milwaukee, Milwaukee, Wisconsin 53211, USA. larsoncl@uwm.eduNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20374544

Citation

Larson, Christine L., et al. "MAOA T941G Polymorphism and the Time Course of Emotional Recovery Following Unpleasant Pictures." Psychophysiology, vol. 47, no. 5, 2010, pp. 857-62.
Larson CL, Taubitz LE, Robinson JS. MAOA T941G polymorphism and the time course of emotional recovery following unpleasant pictures. Psychophysiology. 2010;47(5):857-62.
Larson, C. L., Taubitz, L. E., & Robinson, J. S. (2010). MAOA T941G polymorphism and the time course of emotional recovery following unpleasant pictures. Psychophysiology, 47(5), 857-62. https://doi.org/10.1111/j.1469-8986.2010.01005.x
Larson CL, Taubitz LE, Robinson JS. MAOA T941G Polymorphism and the Time Course of Emotional Recovery Following Unpleasant Pictures. Psychophysiology. 2010;47(5):857-62. PubMed PMID: 20374544.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - MAOA T941G polymorphism and the time course of emotional recovery following unpleasant pictures. AU - Larson,Christine L, AU - Taubitz,Lauren E, AU - Robinson,Jordan S, Y1 - 2010/03/29/ PY - 2010/4/9/entrez PY - 2010/4/9/pubmed PY - 2010/12/14/medline SP - 857 EP - 62 JF - Psychophysiology JO - Psychophysiology VL - 47 IS - 5 N2 - Difficulty down-regulating negative affect has been linked with anxiety and depression. In addition, recent studies have identified specific polymorphisms of the MAOA gene related to affective psychopathology. Here we examined whether genetic variation in MAOA was associated with the time course of responses to affective stimuli. Emotion-modulation of the startle blink response was measured during and after affective pictures. Women with the G/G genotype of the MAOA T941G single nucleotide polymorphism showed sustained reactivity to unpleasant stimuli, as evidenced by continued blink potentiation during the picture-offset period. These data suggest that the MAOA T941G polymorphism, which has been previously linked with mood disorders, is associated with a maladaptive pattern of affective responding in women. SN - 1540-5958 UR - https://www.unboundmedicine.com/medline/citation/20374544/MAOA_T941G_polymorphism_and_the_time_course_of_emotional_recovery_following_unpleasant_pictures_ L2 - https://doi.org/10.1111/j.1469-8986.2010.01005.x DB - PRIME DP - Unbound Medicine ER -