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The ABCs of rhinoviruses, wheezing, and asthma.
J Virol. 2010 Aug; 84(15):7418-26.JV

Abstract

Human rhinoviruses (HRVs) were discovered as common cold pathogens over 50 years ago. Recent advances in molecular viral diagnostics have led to an appreciation of their role in more-significant respiratory illnesses, including bronchiolitis in infancy, childhood pneumonia, and acute exacerbations of chronic respiratory diseases such as asthma, chronic obstructive lung disease, and cystic fibrosis. Until a few years ago, only two groups of HRVs (A and B) had been recognized. However, full and partial sequencing of HRVs led to the discovery of a third species of HRV (HRV-C) that has distinct structural and biologic features. Risk factors and pathogenic mechanisms for more-severe HRV infections are being defined, and yet fundamental questions persist about mechanisms relating this common pathogen to allergic diseases and asthma. The close relationship between HRV infections and asthma suggests that antiviral treatments could have a major impact on the morbidity associated with this chronic respiratory disease.

Authors+Show Affiliations

Department of Pediatrics and Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA. gern@medicine.wisc.edu

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Review

Language

eng

PubMed ID

20375160

Citation

Gern, James E.. "The ABCs of Rhinoviruses, Wheezing, and Asthma." Journal of Virology, vol. 84, no. 15, 2010, pp. 7418-26.
Gern JE. The ABCs of rhinoviruses, wheezing, and asthma. J Virol. 2010;84(15):7418-26.
Gern, J. E. (2010). The ABCs of rhinoviruses, wheezing, and asthma. Journal of Virology, 84(15), 7418-26. https://doi.org/10.1128/JVI.02290-09
Gern JE. The ABCs of Rhinoviruses, Wheezing, and Asthma. J Virol. 2010;84(15):7418-26. PubMed PMID: 20375160.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The ABCs of rhinoviruses, wheezing, and asthma. A1 - Gern,James E, Y1 - 2010/04/07/ PY - 2010/4/9/entrez PY - 2010/4/9/pubmed PY - 2010/7/21/medline SP - 7418 EP - 26 JF - Journal of virology JO - J Virol VL - 84 IS - 15 N2 - Human rhinoviruses (HRVs) were discovered as common cold pathogens over 50 years ago. Recent advances in molecular viral diagnostics have led to an appreciation of their role in more-significant respiratory illnesses, including bronchiolitis in infancy, childhood pneumonia, and acute exacerbations of chronic respiratory diseases such as asthma, chronic obstructive lung disease, and cystic fibrosis. Until a few years ago, only two groups of HRVs (A and B) had been recognized. However, full and partial sequencing of HRVs led to the discovery of a third species of HRV (HRV-C) that has distinct structural and biologic features. Risk factors and pathogenic mechanisms for more-severe HRV infections are being defined, and yet fundamental questions persist about mechanisms relating this common pathogen to allergic diseases and asthma. The close relationship between HRV infections and asthma suggests that antiviral treatments could have a major impact on the morbidity associated with this chronic respiratory disease. SN - 1098-5514 UR - https://www.unboundmedicine.com/medline/citation/20375160/The_ABCs_of_rhinoviruses_wheezing_and_asthma_ L2 - https://journals.asm.org/doi/10.1128/JVI.02290-09?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -