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Accelerated senescence of endothelial progenitor cells in hypertension is related to the reduction of calcitonin gene-related peptide.
J Hypertens. 2010 May; 28(5):931-9.JH

Abstract

OBJECTIVES

To explore whether the accelerated senescence of endothelial progenitor cells (EPCs) is related to the reduction of calcitonin gene-related peptide (CGRP) in hypertension.

METHODS AND RESULTS

In-vivo studies, plasma levels of CGRP and the number of senescent EPCs were measured in hypertensive humans and animals, from which the EPCs were isolated to examine the production of CGRP. Moreover, rutaecarpine, as an agent or tool to stimulate CGRP production, was used in hypertensive animals. The effects of rutaecarpine on angiotensin II-induced EPCs senescence were evaluated in vitro. The results showed that the number of circulating senescent EPCs was significantly increased in hypertension concomitantly with the decreased plasma level of CGRP and the decreased CGRP mRNA expression in EPCs. Administration of rutaecarpine reversed EPC senescence along with an elevation in CGRP production in spontaneously hypertensive rats. In the angiotensin II-induced EPCs senescence, the CGRP mRNA expression was reduced, which was reversed by rutaecarpine. The effect of rutaecarpine on EPCs was canceled in the presence of capsazepine, a selective antagonist of transient receptor potential vanilloid 1.

CONCLUSION

The results suggest that CGRP may work as an endogenous protective substance to counteract EPCs senescence in hypertension and the accelerated EPCs senescence in hypertension was related to the reduction of CGRP.

Authors+Show Affiliations

Department of Pharmacology, School of Pharmaceutical Sciences, Central South University, Changsha, Hunan, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20375903

Citation

Zhou, Zhi, et al. "Accelerated Senescence of Endothelial Progenitor Cells in Hypertension Is Related to the Reduction of Calcitonin Gene-related Peptide." Journal of Hypertension, vol. 28, no. 5, 2010, pp. 931-9.
Zhou Z, Peng J, Wang CJ, et al. Accelerated senescence of endothelial progenitor cells in hypertension is related to the reduction of calcitonin gene-related peptide. J Hypertens. 2010;28(5):931-9.
Zhou, Z., Peng, J., Wang, C. J., Li, D., Li, T. T., Hu, C. P., Chen, X. P., & Li, Y. J. (2010). Accelerated senescence of endothelial progenitor cells in hypertension is related to the reduction of calcitonin gene-related peptide. Journal of Hypertension, 28(5), 931-9. https://doi.org/10.1097/HJH.0b013e3283399326
Zhou Z, et al. Accelerated Senescence of Endothelial Progenitor Cells in Hypertension Is Related to the Reduction of Calcitonin Gene-related Peptide. J Hypertens. 2010;28(5):931-9. PubMed PMID: 20375903.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Accelerated senescence of endothelial progenitor cells in hypertension is related to the reduction of calcitonin gene-related peptide. AU - Zhou,Zhi, AU - Peng,Jun, AU - Wang,Chen-Jing, AU - Li,Dai, AU - Li,Ting-Ting, AU - Hu,Chang-Ping, AU - Chen,Xiao-Ping, AU - Li,Yuan-Jian, PY - 2010/4/9/entrez PY - 2010/4/9/pubmed PY - 2010/7/30/medline SP - 931 EP - 9 JF - Journal of hypertension JO - J Hypertens VL - 28 IS - 5 N2 - OBJECTIVES: To explore whether the accelerated senescence of endothelial progenitor cells (EPCs) is related to the reduction of calcitonin gene-related peptide (CGRP) in hypertension. METHODS AND RESULTS: In-vivo studies, plasma levels of CGRP and the number of senescent EPCs were measured in hypertensive humans and animals, from which the EPCs were isolated to examine the production of CGRP. Moreover, rutaecarpine, as an agent or tool to stimulate CGRP production, was used in hypertensive animals. The effects of rutaecarpine on angiotensin II-induced EPCs senescence were evaluated in vitro. The results showed that the number of circulating senescent EPCs was significantly increased in hypertension concomitantly with the decreased plasma level of CGRP and the decreased CGRP mRNA expression in EPCs. Administration of rutaecarpine reversed EPC senescence along with an elevation in CGRP production in spontaneously hypertensive rats. In the angiotensin II-induced EPCs senescence, the CGRP mRNA expression was reduced, which was reversed by rutaecarpine. The effect of rutaecarpine on EPCs was canceled in the presence of capsazepine, a selective antagonist of transient receptor potential vanilloid 1. CONCLUSION: The results suggest that CGRP may work as an endogenous protective substance to counteract EPCs senescence in hypertension and the accelerated EPCs senescence in hypertension was related to the reduction of CGRP. SN - 1473-5598 UR - https://www.unboundmedicine.com/medline/citation/20375903/Accelerated_senescence_of_endothelial_progenitor_cells_in_hypertension_is_related_to_the_reduction_of_calcitonin_gene_related_peptide_ L2 - https://doi.org/10.1097/HJH.0b013e3283399326 DB - PRIME DP - Unbound Medicine ER -