Tags

Type your tag names separated by a space and hit enter

Impact of donepezil hydrochloride on the care burden of family caregivers of patients with Alzheimer's disease.
Psychogeriatrics. 2009 Dec; 9(4):196-203.P

Abstract

BACKGROUND

To evaluate the impact of donepezil hydrochloride on the care burden on family members of patients with Alzheimer's disease (AD). At present, donepezil is the only drug approved for the treatment of AD in Japan. Although the care burden on primary caregivers of AD patients comprises both physical and psychological burdens and donepezil is recognized to improve cognitive dysfunction and associated symptoms, there are few data on the effects of the drug on the care burden.

METHODS

Of the uninstitutionalized AD patients who visited a dementia clinic between June 2008 and May 2009 with their primary family caregivers, 416 subjects who satisfied the enrollment criteria were registered for the study. All participants provided informed consent. Assessment included changes in scores on the Japanese version of the Zarit Caregiver Burden Interview (J-ZBI) and the Mini-Mental State Examination (MMSE), as well as the presence of behavioral and psychological symptoms of dementia (BPSD). Caregivers answered the questionnaires at baseline and after 12 weeks treatment with donepezil (starting dose 3 mg, p.o., once daily, followed by 5 mg after 1 or 2 weeks).

RESULTS

There were significant changes in mean scores on the J-ZBI (-1.9 +/- 9.5; P < 0.01) and MMSE (+0.9 +/- 2.9; P < 0.01) from baseline to Week 12, without significant correlation between these two scores. In patients with BPSD, there was a significant decrease in J-ZBI scores over the 12 weeks (P = 0.013); in contrast, in patients without BPSD, the decrease in the J-ZBI score did not reach statistical significance (P = 0.418).

CONCLUSIONS

The results indicate that donepezil improves cognitive function and some of the BPSD. As a possible consequence of improvements in BPSD, donepezil may also reduce caregivers' burden.

Authors+Show Affiliations

Department of Psychiatry and Neuropathobiology, Faculty of Medical and Pharmaceutical Sciences, Kumamoto University, Honjo, Kumamoto, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20377821

Citation

Hashimoto, Mamoru, et al. "Impact of Donepezil Hydrochloride On the Care Burden of Family Caregivers of Patients With Alzheimer's Disease." Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society, vol. 9, no. 4, 2009, pp. 196-203.
Hashimoto M, Yatabe Y, Kaneda K, et al. Impact of donepezil hydrochloride on the care burden of family caregivers of patients with Alzheimer's disease. Psychogeriatrics. 2009;9(4):196-203.
Hashimoto, M., Yatabe, Y., Kaneda, K., Honda, K., & Ikeda, M. (2009). Impact of donepezil hydrochloride on the care burden of family caregivers of patients with Alzheimer's disease. Psychogeriatrics : the Official Journal of the Japanese Psychogeriatric Society, 9(4), 196-203. https://doi.org/10.1111/j.1479-8301.2009.00302.x
Hashimoto M, et al. Impact of Donepezil Hydrochloride On the Care Burden of Family Caregivers of Patients With Alzheimer's Disease. Psychogeriatrics. 2009;9(4):196-203. PubMed PMID: 20377821.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Impact of donepezil hydrochloride on the care burden of family caregivers of patients with Alzheimer's disease. AU - Hashimoto,Mamoru, AU - Yatabe,Yusuke, AU - Kaneda,Keiichiro, AU - Honda,Kazuki, AU - Ikeda,Manabu, PY - 2010/4/10/entrez PY - 2010/4/10/pubmed PY - 2010/7/16/medline SP - 196 EP - 203 JF - Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society JO - Psychogeriatrics VL - 9 IS - 4 N2 - BACKGROUND: To evaluate the impact of donepezil hydrochloride on the care burden on family members of patients with Alzheimer's disease (AD). At present, donepezil is the only drug approved for the treatment of AD in Japan. Although the care burden on primary caregivers of AD patients comprises both physical and psychological burdens and donepezil is recognized to improve cognitive dysfunction and associated symptoms, there are few data on the effects of the drug on the care burden. METHODS: Of the uninstitutionalized AD patients who visited a dementia clinic between June 2008 and May 2009 with their primary family caregivers, 416 subjects who satisfied the enrollment criteria were registered for the study. All participants provided informed consent. Assessment included changes in scores on the Japanese version of the Zarit Caregiver Burden Interview (J-ZBI) and the Mini-Mental State Examination (MMSE), as well as the presence of behavioral and psychological symptoms of dementia (BPSD). Caregivers answered the questionnaires at baseline and after 12 weeks treatment with donepezil (starting dose 3 mg, p.o., once daily, followed by 5 mg after 1 or 2 weeks). RESULTS: There were significant changes in mean scores on the J-ZBI (-1.9 +/- 9.5; P < 0.01) and MMSE (+0.9 +/- 2.9; P < 0.01) from baseline to Week 12, without significant correlation between these two scores. In patients with BPSD, there was a significant decrease in J-ZBI scores over the 12 weeks (P = 0.013); in contrast, in patients without BPSD, the decrease in the J-ZBI score did not reach statistical significance (P = 0.418). CONCLUSIONS: The results indicate that donepezil improves cognitive function and some of the BPSD. As a possible consequence of improvements in BPSD, donepezil may also reduce caregivers' burden. SN - 1479-8301 UR - https://www.unboundmedicine.com/medline/citation/20377821/Impact_of_donepezil_hydrochloride_on_the_care_burden_of_family_caregivers_of_patients_with_Alzheimer's_disease_ L2 - https://doi.org/10.1111/j.1479-8301.2009.00302.x DB - PRIME DP - Unbound Medicine ER -