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The effects of cannabis and alcohol on simulated arterial driving: Influences of driving experience and task demand.
Accid Anal Prev 2010; 42(3):859-66AA

Abstract

This study compared the effects of three doses of cannabis and alcohol (placebo, low and high doses), both alone and in combination, on the driving performance of young, novice drivers and more experienced drivers. Alcohol was administered as ethanol (95%) mixed with orange juice in doses of approximately 0, 0.4 and 0.6g/kg. Cannabis was administered by inhalation of smoke from pre-rolled cannabis cigarettes (supplied by the National Institute of Drug Abuse, USA). Active cigarettes contained 19 mg delta-9-THC. Using a counterbalanced design, the simulated driving performance of 25 experienced and 22 inexperienced drivers was tested under the nine different drug conditions in an arterial driving environment during which workload was varied through the drive characteristics as well as through the inclusion of a secondary task. High levels of cannabis generally induced greater impairment than lower levels, while alcohol at the doses used had few effects and did not produce synergistic effects when combined with cannabis. Both cannabis and alcohol were associated with increases in speed and lateral position variability, high dose cannabis was associated with decreased mean speed, increased mean and variability in headways, and longer reaction time, while in contrast alcohol was associated with a slight increase in mean speed. Given the limitations of the study, it is of great interest to further explore the qualitative impairments in driving performance associated with cannabis and alcohol separately and how these impairments may manifest in terms of crash characteristics.

Authors+Show Affiliations

Monash University Accident Research Centre, Monash University, Victoria 3800, Australia. Michael.Lenne@muarc.monash.edu.auNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20380913

Citation

Lenné, Michael G., et al. "The Effects of Cannabis and Alcohol On Simulated Arterial Driving: Influences of Driving Experience and Task Demand." Accident; Analysis and Prevention, vol. 42, no. 3, 2010, pp. 859-66.
Lenné MG, Dietze PM, Triggs TJ, et al. The effects of cannabis and alcohol on simulated arterial driving: Influences of driving experience and task demand. Accid Anal Prev. 2010;42(3):859-66.
Lenné, M. G., Dietze, P. M., Triggs, T. J., Walmsley, S., Murphy, B., & Redman, J. R. (2010). The effects of cannabis and alcohol on simulated arterial driving: Influences of driving experience and task demand. Accident; Analysis and Prevention, 42(3), pp. 859-66. doi:10.1016/j.aap.2009.04.021.
Lenné MG, et al. The Effects of Cannabis and Alcohol On Simulated Arterial Driving: Influences of Driving Experience and Task Demand. Accid Anal Prev. 2010;42(3):859-66. PubMed PMID: 20380913.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of cannabis and alcohol on simulated arterial driving: Influences of driving experience and task demand. AU - Lenné,Michael G, AU - Dietze,Paul M, AU - Triggs,Thomas J, AU - Walmsley,Susan, AU - Murphy,Brendan, AU - Redman,Jennifer R, PY - 2008/08/14/received PY - 2008/12/23/revised PY - 2009/04/21/accepted PY - 2010/4/13/entrez PY - 2010/4/13/pubmed PY - 2011/1/7/medline SP - 859 EP - 66 JF - Accident; analysis and prevention JO - Accid Anal Prev VL - 42 IS - 3 N2 - This study compared the effects of three doses of cannabis and alcohol (placebo, low and high doses), both alone and in combination, on the driving performance of young, novice drivers and more experienced drivers. Alcohol was administered as ethanol (95%) mixed with orange juice in doses of approximately 0, 0.4 and 0.6g/kg. Cannabis was administered by inhalation of smoke from pre-rolled cannabis cigarettes (supplied by the National Institute of Drug Abuse, USA). Active cigarettes contained 19 mg delta-9-THC. Using a counterbalanced design, the simulated driving performance of 25 experienced and 22 inexperienced drivers was tested under the nine different drug conditions in an arterial driving environment during which workload was varied through the drive characteristics as well as through the inclusion of a secondary task. High levels of cannabis generally induced greater impairment than lower levels, while alcohol at the doses used had few effects and did not produce synergistic effects when combined with cannabis. Both cannabis and alcohol were associated with increases in speed and lateral position variability, high dose cannabis was associated with decreased mean speed, increased mean and variability in headways, and longer reaction time, while in contrast alcohol was associated with a slight increase in mean speed. Given the limitations of the study, it is of great interest to further explore the qualitative impairments in driving performance associated with cannabis and alcohol separately and how these impairments may manifest in terms of crash characteristics. SN - 1879-2057 UR - https://www.unboundmedicine.com/medline/citation/20380913/abstract/The_effects_of_cannabis_and_alcohol_on_simulated_arterial_driving:_Influences_of_driving_experience_and_task_demand_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0001-4575(09)00091-8 DB - PRIME DP - Unbound Medicine ER -