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More than the sum of its parts? Nutrition in Alzheimer's disease.
Nutrition 2010 Jul-Aug; 26(7-8):694-700N

Abstract

The aim of this article is to emphasize the importance of malnutrition and micronutrient deficiencies in Alzheimer's disease and discuss recent supplementation trials. Alzheimer's disease (AD) is a devastating neurodegenerative disease with increasing socio-economic impact. It leads to cognitive decline over the years, finally resulting in brain atrophy and gradually destroying a person's ability to learn, reason, make judgments, and communicate. Most of the cases are sporadic and risk factors evolve. There is evidence that malnutrition, oxidative stress, and homocysteine-related vitamins play a role in the pathogenesis of AD. A plethora of epidemiologic studies have explored the associations between nutrients and AD. In addition, more and more data from recent trials are evolving to analyze the impact of micronutrient supplementation in AD and incipient AD concerning B vitamin status and antioxidants. Available data do not support definitive conclusions regarding specific recommendations on micronutrient supplementation for the prevention or treatment of AD; however, more data from prospective trials are needed. Approaches with multiple nutritional components might be promising.

Authors+Show Affiliations

Department of Neurology, Ulm University, Ulm, Germany. christine.arnim@uni-ulm.deNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20381316

Citation

von Arnim, Christine A F., et al. "More Than the Sum of Its Parts? Nutrition in Alzheimer's Disease." Nutrition (Burbank, Los Angeles County, Calif.), vol. 26, no. 7-8, 2010, pp. 694-700.
von Arnim CA, Gola U, Biesalski HK. More than the sum of its parts? Nutrition in Alzheimer's disease. Nutrition. 2010;26(7-8):694-700.
von Arnim, C. A., Gola, U., & Biesalski, H. K. (2010). More than the sum of its parts? Nutrition in Alzheimer's disease. Nutrition (Burbank, Los Angeles County, Calif.), 26(7-8), pp. 694-700. doi:10.1016/j.nut.2009.11.009.
von Arnim CA, Gola U, Biesalski HK. More Than the Sum of Its Parts? Nutrition in Alzheimer's Disease. Nutrition. 2010;26(7-8):694-700. PubMed PMID: 20381316.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - More than the sum of its parts? Nutrition in Alzheimer's disease. AU - von Arnim,Christine A F, AU - Gola,Ute, AU - Biesalski,Hans K, Y1 - 2010/04/08/ PY - 2009/08/10/received PY - 2009/10/23/revised PY - 2009/11/05/accepted PY - 2010/4/13/entrez PY - 2010/4/13/pubmed PY - 2011/1/15/medline SP - 694 EP - 700 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 26 IS - 7-8 N2 - The aim of this article is to emphasize the importance of malnutrition and micronutrient deficiencies in Alzheimer's disease and discuss recent supplementation trials. Alzheimer's disease (AD) is a devastating neurodegenerative disease with increasing socio-economic impact. It leads to cognitive decline over the years, finally resulting in brain atrophy and gradually destroying a person's ability to learn, reason, make judgments, and communicate. Most of the cases are sporadic and risk factors evolve. There is evidence that malnutrition, oxidative stress, and homocysteine-related vitamins play a role in the pathogenesis of AD. A plethora of epidemiologic studies have explored the associations between nutrients and AD. In addition, more and more data from recent trials are evolving to analyze the impact of micronutrient supplementation in AD and incipient AD concerning B vitamin status and antioxidants. Available data do not support definitive conclusions regarding specific recommendations on micronutrient supplementation for the prevention or treatment of AD; however, more data from prospective trials are needed. Approaches with multiple nutritional components might be promising. SN - 1873-1244 UR - https://www.unboundmedicine.com/medline/citation/20381316/More_than_the_sum_of_its_parts_Nutrition_in_Alzheimer's_disease_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(09)00448-1 DB - PRIME DP - Unbound Medicine ER -