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Nut consumption and risk of stroke in US male physicians.
Clin Nutr 2010; 29(5):605-9CN

Abstract

BACKGROUND & AIMS

While nut consumption has been shown to lower the risk of hypertension and coronary disease, it is not known whether nut consumption is associated with the risk of stroke. We sought to examine whether nut consumption is associated with total and subtypes of stroke.

METHODS

Prospective cohort of 21,078 participants from the Physicians' Health Study (1982-2008) who were free of stroke at baseline. Nut consumption was assessed using a simple 19-item food questionnaire and stroke cases were confirmed after reviewing medical records. We used Cox's proportional hazards regression to estimate relative risks of total, ischemic, and hemorrhagic stroke according to consumption of any nuts.

RESULTS

During a mean follow up of 21.1 years, 1424 incident cases of stroke occurred (219 hemorrhagic, 1189 ischemic, and 16 of undetermined cause). There was no statistically significant association between nut consumption and total or ischemic stroke. In contrast, there was a suggestive non-linear relation between nut intake and hemorrhagic stroke: compared to subjects who did not consume nuts, multivariable-adjusted hazard ratios (95% CI) for hemorrhagic stroke for subjects consuming nuts <1, 1, 2-4, 5-6, and ≥7 times/week were 1.13 (0.78-1.62), 1.05 (0.70-1.58), 0.49 (0.27-0.89), 1.50 (0.79-2.84), and 1.84 (0.95-3.57), respectively (p for quadratic trend 0.12).

CONCLUSIONS

Our data showed no association between nuts and ischemic stroke and suggested a J-shaped relation between nut consumption and hemorrhagic stroke. Replication of our findings in the general population is warranted.

Authors+Show Affiliations

Division of Aging, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02120, USA. ldjousse@rics.bwh.harvard.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Randomized Controlled Trial
Research Support, N.I.H., Extramural

Language

eng

PubMed ID

20381933

Citation

Djoussé, Luc, et al. "Nut Consumption and Risk of Stroke in US Male Physicians." Clinical Nutrition (Edinburgh, Scotland), vol. 29, no. 5, 2010, pp. 605-9.
Djoussé L, Gaziano JM, Kase CS, et al. Nut consumption and risk of stroke in US male physicians. Clin Nutr. 2010;29(5):605-9.
Djoussé, L., Gaziano, J. M., Kase, C. S., & Kurth, T. (2010). Nut consumption and risk of stroke in US male physicians. Clinical Nutrition (Edinburgh, Scotland), 29(5), pp. 605-9. doi:10.1016/j.clnu.2010.03.005.
Djoussé L, et al. Nut Consumption and Risk of Stroke in US Male Physicians. Clin Nutr. 2010;29(5):605-9. PubMed PMID: 20381933.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Nut consumption and risk of stroke in US male physicians. AU - Djoussé,Luc, AU - Gaziano,J Michael, AU - Kase,Carlos S, AU - Kurth,Tobias, Y1 - 2010/04/09/ PY - 2009/09/30/received PY - 2010/02/03/revised PY - 2010/03/11/accepted PY - 2010/4/13/entrez PY - 2010/4/13/pubmed PY - 2011/1/21/medline SP - 605 EP - 9 JF - Clinical nutrition (Edinburgh, Scotland) JO - Clin Nutr VL - 29 IS - 5 N2 - BACKGROUND & AIMS: While nut consumption has been shown to lower the risk of hypertension and coronary disease, it is not known whether nut consumption is associated with the risk of stroke. We sought to examine whether nut consumption is associated with total and subtypes of stroke. METHODS: Prospective cohort of 21,078 participants from the Physicians' Health Study (1982-2008) who were free of stroke at baseline. Nut consumption was assessed using a simple 19-item food questionnaire and stroke cases were confirmed after reviewing medical records. We used Cox's proportional hazards regression to estimate relative risks of total, ischemic, and hemorrhagic stroke according to consumption of any nuts. RESULTS: During a mean follow up of 21.1 years, 1424 incident cases of stroke occurred (219 hemorrhagic, 1189 ischemic, and 16 of undetermined cause). There was no statistically significant association between nut consumption and total or ischemic stroke. In contrast, there was a suggestive non-linear relation between nut intake and hemorrhagic stroke: compared to subjects who did not consume nuts, multivariable-adjusted hazard ratios (95% CI) for hemorrhagic stroke for subjects consuming nuts <1, 1, 2-4, 5-6, and ≥7 times/week were 1.13 (0.78-1.62), 1.05 (0.70-1.58), 0.49 (0.27-0.89), 1.50 (0.79-2.84), and 1.84 (0.95-3.57), respectively (p for quadratic trend 0.12). CONCLUSIONS: Our data showed no association between nuts and ischemic stroke and suggested a J-shaped relation between nut consumption and hemorrhagic stroke. Replication of our findings in the general population is warranted. SN - 1532-1983 UR - https://www.unboundmedicine.com/medline/citation/20381933/Nut_consumption_and_risk_of_stroke_in_US_male_physicians_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0261-5614(10)00064-6 DB - PRIME DP - Unbound Medicine ER -