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Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids.
J Nutr Biochem. 2010 Sep; 21(9):781-92.JN

Abstract

Typical omega 3 polyunsaturated fatty acids (n-3 PUFAs) are docosahexaenoic acid and eicosapentaenoic acid in the form of fish oils and alpha linolenic acid from flaxseed oil. Epidemiological studies suggested the benefits of n-3 PUFA on cardiovascular health. Intervention studies confirmed that the consumption of n-3 PUFA provided benefits for primary and secondary prevention of cardiovascular disease. Evidence from cellular and molecular research studies indicates that the cardioprotective effects of n-3 PUFA result from a synergism between multiple, intricate mechanisms that involve antiinflammation, proresolving lipid mediators, modulation of cardiac ion channels, reduction of triglycerides, influence on membrane microdomains and downstream cell signaling pathways and antithrombotic and antiarrhythmic effects. n-3 PUFAs inhibit inflammatory signaling pathways (nuclear factor-kappa B activity) and down-regulate fatty acid (FA) synthesis gene expression (sterol regulatory element binding protein-1c) and up-regulate gene expression involved in FA oxidation (peroxisome proliferator-activated receptor alpha). This review examines the various mechanisms by which n-3 PUFA exert beneficial effects against CVD.

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Authors+Show Affiliations

Adkins Y
Western Human Nutrition Research Center, ARS, USDA, University of California Davis, CA 95616, USA.
Kelley DS
No affiliation info available

MeSH

Cardiovascular DiseasesDietary FatsDocosahexaenoic AcidsDown-RegulationEicosapentaenoic AcidEndothelium, VascularFatty Acids, Omega-3Fish OilsHumansInflammationLinseed OilNF-kappa BPPAR alphaSterol Regulatory Element Binding Protein 1ThrombosisToll-Like Receptor 4TriglyceridesUp-Regulationalpha-Linolenic Acid

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20382009

Citation

Adkins, Yuriko, and Darshan S. Kelley. "Mechanisms Underlying the Cardioprotective Effects of Omega-3 Polyunsaturated Fatty Acids." The Journal of Nutritional Biochemistry, vol. 21, no. 9, 2010, pp. 781-92.
Adkins Y, Kelley DS. Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids. J Nutr Biochem. 2010;21(9):781-92.
Adkins, Y., & Kelley, D. S. (2010). Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids. The Journal of Nutritional Biochemistry, 21(9), 781-92. https://doi.org/10.1016/j.jnutbio.2009.12.004
Adkins Y, Kelley DS. Mechanisms Underlying the Cardioprotective Effects of Omega-3 Polyunsaturated Fatty Acids. J Nutr Biochem. 2010;21(9):781-92. PubMed PMID: 20382009.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanisms underlying the cardioprotective effects of omega-3 polyunsaturated fatty acids. AU - Adkins,Yuriko, AU - Kelley,Darshan S, Y1 - 2010/04/10/ PY - 2009/10/06/received PY - 2009/12/01/revised PY - 2009/12/03/accepted PY - 2010/4/13/entrez PY - 2010/4/13/pubmed PY - 2010/12/14/medline SP - 781 EP - 92 JF - The Journal of nutritional biochemistry JO - J. Nutr. Biochem. VL - 21 IS - 9 N2 - Typical omega 3 polyunsaturated fatty acids (n-3 PUFAs) are docosahexaenoic acid and eicosapentaenoic acid in the form of fish oils and alpha linolenic acid from flaxseed oil. Epidemiological studies suggested the benefits of n-3 PUFA on cardiovascular health. Intervention studies confirmed that the consumption of n-3 PUFA provided benefits for primary and secondary prevention of cardiovascular disease. Evidence from cellular and molecular research studies indicates that the cardioprotective effects of n-3 PUFA result from a synergism between multiple, intricate mechanisms that involve antiinflammation, proresolving lipid mediators, modulation of cardiac ion channels, reduction of triglycerides, influence on membrane microdomains and downstream cell signaling pathways and antithrombotic and antiarrhythmic effects. n-3 PUFAs inhibit inflammatory signaling pathways (nuclear factor-kappa B activity) and down-regulate fatty acid (FA) synthesis gene expression (sterol regulatory element binding protein-1c) and up-regulate gene expression involved in FA oxidation (peroxisome proliferator-activated receptor alpha). This review examines the various mechanisms by which n-3 PUFA exert beneficial effects against CVD. SN - 1873-4847 UR - https://www.unboundmedicine.com/medline/citation/20382009/Mechanisms_underlying_the_cardioprotective_effects_of_omega_3_polyunsaturated_fatty_acids_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0955-2863(10)00013-6 DB - PRIME DP - Unbound Medicine ER -