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Association of electrocardiographic changes with severity of coronary artery disease and short term outcome in patients with non-ST-segment elevation acute coronary syndromes.
Saudi Med J. 2010 Apr; 31(4):400-5.SM

Abstract

OBJECTIVE

To assess the association between electrocardiogram (ECG) changes in non-ST-segment elevation acute coronary syndrome (NSTE- ACS) patients with severity of coronary artery disease (CAD) and short-term outcome.

METHODS

In this cross-sectional descriptive-analytical study, 111 patients admitted to the Cardiology Department of Shahid Madani Heart Hospital, Tabriz, Iran between March 2005 and March 2007 with first NSTE-ACS, and had undergone coronary angiography during index event were evaluated.

RESULTS

One hundred and eleven patients (64 males, and 47 females) were enrolled, and their in-hospital and short-term outcome with a mean follow-up period of 4.6 +/- 1.8 months was evaluated. Patients with ST-T changes on admission had higher rates of death (16.7 versus 2.7%, p=0.01), recurrent angina (36.1 versus 6.7%, p=0.001), and pulmonary edema (8.3 versus 1.3%, p=0.045). The mean left ventricular ejection fraction (LVEF) of patients with ECG changes were significantly lower than those without ECG changes (p=0.001). Mitral regurgitation (MR) was also more common among those with ECG changes (p=0.006). In a multivariate regression analysis, the only independent predictor of short-term mortality and adverse clinical event was ST depression on ECG (p=0.001).

CONCLUSION

In patients with first NSTE-ACS, ST deviation is associated with adverse short-term outcome including more severe CAD, lower LVEF, and more common MR.

Authors+Show Affiliations

Cardiology Department, Shahid Madani Heart Hospital, Daneshgah St., Postal Code 5166615573, Tabriz, Iran. ghafaris@gmail.comNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20383417

Citation

Ghaffari, Samad, et al. "Association of Electrocardiographic Changes With Severity of Coronary Artery Disease and Short Term Outcome in Patients With non-ST-segment Elevation Acute Coronary Syndromes." Saudi Medical Journal, vol. 31, no. 4, 2010, pp. 400-5.
Ghaffari S, Separham A, Pourafkari L. Association of electrocardiographic changes with severity of coronary artery disease and short term outcome in patients with non-ST-segment elevation acute coronary syndromes. Saudi Med J. 2010;31(4):400-5.
Ghaffari, S., Separham, A., & Pourafkari, L. (2010). Association of electrocardiographic changes with severity of coronary artery disease and short term outcome in patients with non-ST-segment elevation acute coronary syndromes. Saudi Medical Journal, 31(4), 400-5.
Ghaffari S, Separham A, Pourafkari L. Association of Electrocardiographic Changes With Severity of Coronary Artery Disease and Short Term Outcome in Patients With non-ST-segment Elevation Acute Coronary Syndromes. Saudi Med J. 2010;31(4):400-5. PubMed PMID: 20383417.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Association of electrocardiographic changes with severity of coronary artery disease and short term outcome in patients with non-ST-segment elevation acute coronary syndromes. AU - Ghaffari,Samad, AU - Separham,Ahmad, AU - Pourafkari,Leili, PY - 2010/4/13/entrez PY - 2010/4/13/pubmed PY - 2010/8/31/medline SP - 400 EP - 5 JF - Saudi medical journal JO - Saudi Med J VL - 31 IS - 4 N2 - OBJECTIVE: To assess the association between electrocardiogram (ECG) changes in non-ST-segment elevation acute coronary syndrome (NSTE- ACS) patients with severity of coronary artery disease (CAD) and short-term outcome. METHODS: In this cross-sectional descriptive-analytical study, 111 patients admitted to the Cardiology Department of Shahid Madani Heart Hospital, Tabriz, Iran between March 2005 and March 2007 with first NSTE-ACS, and had undergone coronary angiography during index event were evaluated. RESULTS: One hundred and eleven patients (64 males, and 47 females) were enrolled, and their in-hospital and short-term outcome with a mean follow-up period of 4.6 +/- 1.8 months was evaluated. Patients with ST-T changes on admission had higher rates of death (16.7 versus 2.7%, p=0.01), recurrent angina (36.1 versus 6.7%, p=0.001), and pulmonary edema (8.3 versus 1.3%, p=0.045). The mean left ventricular ejection fraction (LVEF) of patients with ECG changes were significantly lower than those without ECG changes (p=0.001). Mitral regurgitation (MR) was also more common among those with ECG changes (p=0.006). In a multivariate regression analysis, the only independent predictor of short-term mortality and adverse clinical event was ST depression on ECG (p=0.001). CONCLUSION: In patients with first NSTE-ACS, ST deviation is associated with adverse short-term outcome including more severe CAD, lower LVEF, and more common MR. SN - 0379-5284 UR - https://www.unboundmedicine.com/medline/citation/20383417/Association_of_electrocardiographic_changes_with_severity_of_coronary_artery_disease_and_short_term_outcome_in_patients_with_non_ST_segment_elevation_acute_coronary_syndromes_ DB - PRIME DP - Unbound Medicine ER -