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Impact of smoking on bone mineral density and bone metabolism in elderly men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study.

Abstract

Our cross-sectional analysis of 1,576 men aged ≥65 years examined smoking effects on bone status. Number of smoking years was associated with decreased bone mineral density (BMD), after adjusting for age, height, weight, and number of cigarettes smoked daily. Smoking did not affect biochemical marker serum values for bone turnover.

INTRODUCTION

The impact of smoking on bone status in men has not been conclusively established. We examined how smoking and its cessation influence bone status and metabolism in men.

METHODS

We analyzed 1,576 men among a baseline survey of Japanese men aged ≥65 years, the Fujiwara-kyo Osteoporosis Risk in Men study, conducted during 2007-2008.

RESULTS

Lumbar spine (LS) BMD values among never, former, and current smokers were 1.045 ± 0.194, 1.030 ± 0.189, and 1.001 ± 0.182 g/cm(2) (P = 0.005), respectively, while total hip (TH) BMD values were 0.888 ± 0.120, 0.885 ± 0.127, and 0.870 ± 0.124 (P = 0.078), respectively. The significant trend for LS BMD remained after adjusting for the covariates; age, height, weight, physical activity, milk consumption, and drinking habit (P = 0.036). Among never and ever (current and former) smokers, LS and TH BMD decreased with the number of pack years or the number of smoking years, respectively, adjusted for those covariates. Among ever smokers, LS and TH BMD decreased with the number of smoking years after adjusting for age, height, weight, and number of cigarettes smoked daily. Smoking did not reveal significant effect for serum osteocalcin or tartrate resistant acid phosphatase isoenzyme 5b.

CONCLUSION

The impact of smoking on bone status is mainly associated with the number of smoking years in elderly men.

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  • Authors+Show Affiliations

    ,

    Department of Public Health, Kinki University School of Medicine, 377-2, Oono-higasi, Osaka-sayama, Osaka, 589-8511, Japan.

    , , , , , , , , ,

    Source

    MeSH

    Acid Phosphatase
    Aged
    Biomarkers
    Bone Density
    Bone and Bones
    Cross-Sectional Studies
    Hip Joint
    Humans
    Isoenzymes
    Lumbar Vertebrae
    Male
    Osteocalcin
    Osteoporosis
    Smoking
    Smoking Cessation
    Tartrate-Resistant Acid Phosphatase

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    20383631

    Citation

    Tamaki, J, et al. "Impact of Smoking On Bone Mineral Density and Bone Metabolism in Elderly Men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study." Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, vol. 22, no. 1, 2011, pp. 133-41.
    Tamaki J, Iki M, Fujita Y, et al. Impact of smoking on bone mineral density and bone metabolism in elderly men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study. Osteoporos Int. 2011;22(1):133-41.
    Tamaki, J., Iki, M., Fujita, Y., Kouda, K., Yura, A., Kadowaki, E., ... Kurumatani, N. (2011). Impact of smoking on bone mineral density and bone metabolism in elderly men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study. Osteoporosis International : a Journal Established as Result of Cooperation Between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA, 22(1), pp. 133-41. doi:10.1007/s00198-010-1238-x.
    Tamaki J, et al. Impact of Smoking On Bone Mineral Density and Bone Metabolism in Elderly Men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) Study. Osteoporos Int. 2011;22(1):133-41. PubMed PMID: 20383631.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Impact of smoking on bone mineral density and bone metabolism in elderly men: the Fujiwara-kyo Osteoporosis Risk in Men (FORMEN) study. AU - Tamaki,J, AU - Iki,M, AU - Fujita,Y, AU - Kouda,K, AU - Yura,A, AU - Kadowaki,E, AU - Sato,Y, AU - Moon,J S, AU - Tomioka,K, AU - Okamoto,N, AU - Kurumatani,N, Y1 - 2010/04/10/ PY - 2009/11/26/received PY - 2010/03/01/accepted PY - 2010/4/13/entrez PY - 2010/4/13/pubmed PY - 2011/8/31/medline SP - 133 EP - 41 JF - Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA JO - Osteoporos Int VL - 22 IS - 1 N2 - UNLABELLED: Our cross-sectional analysis of 1,576 men aged ≥65 years examined smoking effects on bone status. Number of smoking years was associated with decreased bone mineral density (BMD), after adjusting for age, height, weight, and number of cigarettes smoked daily. Smoking did not affect biochemical marker serum values for bone turnover. INTRODUCTION: The impact of smoking on bone status in men has not been conclusively established. We examined how smoking and its cessation influence bone status and metabolism in men. METHODS: We analyzed 1,576 men among a baseline survey of Japanese men aged ≥65 years, the Fujiwara-kyo Osteoporosis Risk in Men study, conducted during 2007-2008. RESULTS: Lumbar spine (LS) BMD values among never, former, and current smokers were 1.045 ± 0.194, 1.030 ± 0.189, and 1.001 ± 0.182 g/cm(2) (P = 0.005), respectively, while total hip (TH) BMD values were 0.888 ± 0.120, 0.885 ± 0.127, and 0.870 ± 0.124 (P = 0.078), respectively. The significant trend for LS BMD remained after adjusting for the covariates; age, height, weight, physical activity, milk consumption, and drinking habit (P = 0.036). Among never and ever (current and former) smokers, LS and TH BMD decreased with the number of pack years or the number of smoking years, respectively, adjusted for those covariates. Among ever smokers, LS and TH BMD decreased with the number of smoking years after adjusting for age, height, weight, and number of cigarettes smoked daily. Smoking did not reveal significant effect for serum osteocalcin or tartrate resistant acid phosphatase isoenzyme 5b. CONCLUSION: The impact of smoking on bone status is mainly associated with the number of smoking years in elderly men. SN - 1433-2965 UR - https://www.unboundmedicine.com/medline/citation/20383631/Impact_of_smoking_on_bone_mineral_density_and_bone_metabolism_in_elderly_men:_the_Fujiwara_kyo_Osteoporosis_Risk_in_Men__FORMEN__study_ L2 - https://dx.doi.org/10.1007/s00198-010-1238-x DB - PRIME DP - Unbound Medicine ER -