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Electrochemical study of the antiplatelet agent clopidogrel and its determination using differential pulse voltammetry in bulk form and pharmaceutical preparations with a glassy carbon electrode.
Pharmazie. 2010 Mar; 65(3):175-81.P

Abstract

In the present study, the electroanalytical behaviour of clopidogrel (CLP) bisulfate, an antithrombotic drug, was investigated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques using a glassy carbon electrode (GCE). The anodic oxidation of clopidogrel bisulfate was investigated with a GCE to determine the oxidation conditions. The voltammograms of solutions having various concentrations of clopidogrel were recorded in order to obtain the optimum oxidation conditions of this drug on a GCE. To determine the effects of the nature of the supporting electrolyte, pH and scan rate on the anodic oxidation reactions, the experiments were performed in 0.2 M sulphuric acid, and in Britton-Robinson (BR) (pH 2-5) and acetate (pH 3.5-5.63) buffers with a 10-400 mVs(-1) scan rate interval. The oxidation of clopidogrel bisulfate was found to be diffusion-controlled over a concentration range of 0.08 mM-1.0 mM in pH 3.7 acetate buffer by an optimized DPV technique. The voltammetric method developed was applied to the tablet form of pharmaceutical preparation of this compound and the accuracy, precision, selectivity, sensitivity, repeatibility within and between days and reproducibility of the proposed method was investigated statistically. The results were compared with the spectrophotometric and HPLC methods developed in our laboratory and found to be in good agreement. No interference was observed from common pharmaceutical adjuvants.

Authors+Show Affiliations

Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, Tandoğan-Ankara, Turkey. dermis@pharmacy.ankara.edu.trNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20383936

Citation

Dermiş, S, and E Aydoğan. "Electrochemical Study of the Antiplatelet Agent Clopidogrel and Its Determination Using Differential Pulse Voltammetry in Bulk Form and Pharmaceutical Preparations With a Glassy Carbon Electrode." Die Pharmazie, vol. 65, no. 3, 2010, pp. 175-81.
Dermiş S, Aydoğan E. Electrochemical study of the antiplatelet agent clopidogrel and its determination using differential pulse voltammetry in bulk form and pharmaceutical preparations with a glassy carbon electrode. Pharmazie. 2010;65(3):175-81.
Dermiş, S., & Aydoğan, E. (2010). Electrochemical study of the antiplatelet agent clopidogrel and its determination using differential pulse voltammetry in bulk form and pharmaceutical preparations with a glassy carbon electrode. Die Pharmazie, 65(3), 175-81.
Dermiş S, Aydoğan E. Electrochemical Study of the Antiplatelet Agent Clopidogrel and Its Determination Using Differential Pulse Voltammetry in Bulk Form and Pharmaceutical Preparations With a Glassy Carbon Electrode. Pharmazie. 2010;65(3):175-81. PubMed PMID: 20383936.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrochemical study of the antiplatelet agent clopidogrel and its determination using differential pulse voltammetry in bulk form and pharmaceutical preparations with a glassy carbon electrode. AU - Dermiş,S, AU - Aydoğan,E, PY - 2010/4/14/entrez PY - 2010/4/14/pubmed PY - 2010/5/21/medline SP - 175 EP - 81 JF - Die Pharmazie JO - Pharmazie VL - 65 IS - 3 N2 - In the present study, the electroanalytical behaviour of clopidogrel (CLP) bisulfate, an antithrombotic drug, was investigated by cyclic voltammetry (CV) and differential pulse voltammetry (DPV) techniques using a glassy carbon electrode (GCE). The anodic oxidation of clopidogrel bisulfate was investigated with a GCE to determine the oxidation conditions. The voltammograms of solutions having various concentrations of clopidogrel were recorded in order to obtain the optimum oxidation conditions of this drug on a GCE. To determine the effects of the nature of the supporting electrolyte, pH and scan rate on the anodic oxidation reactions, the experiments were performed in 0.2 M sulphuric acid, and in Britton-Robinson (BR) (pH 2-5) and acetate (pH 3.5-5.63) buffers with a 10-400 mVs(-1) scan rate interval. The oxidation of clopidogrel bisulfate was found to be diffusion-controlled over a concentration range of 0.08 mM-1.0 mM in pH 3.7 acetate buffer by an optimized DPV technique. The voltammetric method developed was applied to the tablet form of pharmaceutical preparation of this compound and the accuracy, precision, selectivity, sensitivity, repeatibility within and between days and reproducibility of the proposed method was investigated statistically. The results were compared with the spectrophotometric and HPLC methods developed in our laboratory and found to be in good agreement. No interference was observed from common pharmaceutical adjuvants. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/20383936/Electrochemical_study_of_the_antiplatelet_agent_clopidogrel_and_its_determination_using_differential_pulse_voltammetry_in_bulk_form_and_pharmaceutical_preparations_with_a_glassy_carbon_electrode_ DB - PRIME DP - Unbound Medicine ER -