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Electrochemical behaviour of sertraline hydrochloride at a glassy carbon electrode and its determination in pharmaceutical products using osteryoung square wave voltammetry.
Pharmazie. 2010 Mar; 65(3):182-7.P

Abstract

In this study the electrooxidation of sertraline (STR) hydrochloride in pH 8 Britton-Robinson buffer (BRb) -methanol (MeOH) (1:1,v/v) supporting electrolyte was investigated using Osteryoung Square Wave Voltammetry (OSWV) with the glassy carbon electrode. OSWV is a rapid and sensitive electro-analytical technique for sertraline determination. This study indicated that sertraline was susceptible to oxidation. The effects of the supporting electrolyte, pH and scan rate on the anodic reactions performed in BRb and a scan rate interval 5 - 1000 mVs(-1) were investigated. Sertraline hydrochloride was oxidized irreversibly and diffusion controlled. OSWV was selected for the quantitative determination. Using optimized OSWV technique, the current was linear within a concentration range of 0.04-0.8 mM in pH 8 BRb which at the equivalent volume with MeOH. The applicability of the proposed method was shown by the successful analysis of sertraline in tablet dosage forms. Accuracy, precision, selectivity, sensitivity, within day and between days reproducibility of the method were investigated statistically. Application of the suggested method to pharmaceutical formulation is presented and compared with the UV spectrophotometric and HPLC methods. The results were found to be in a good agreement. No interference was observed from common pharmaceutical adjuvants.

Authors+Show Affiliations

Ankara University, Faculty of Pharmacy, Department of Analytical Chemistry, Tandoğan-Ankara, Turkey. dermis@pharmacy.ankara.edu.trNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20383937

Citation

Dermiş, S, and H Y. Cay. "Electrochemical Behaviour of Sertraline Hydrochloride at a Glassy Carbon Electrode and Its Determination in Pharmaceutical Products Using Osteryoung Square Wave Voltammetry." Die Pharmazie, vol. 65, no. 3, 2010, pp. 182-7.
Dermiş S, Cay HY. Electrochemical behaviour of sertraline hydrochloride at a glassy carbon electrode and its determination in pharmaceutical products using osteryoung square wave voltammetry. Pharmazie. 2010;65(3):182-7.
Dermiş, S., & Cay, H. Y. (2010). Electrochemical behaviour of sertraline hydrochloride at a glassy carbon electrode and its determination in pharmaceutical products using osteryoung square wave voltammetry. Die Pharmazie, 65(3), 182-7.
Dermiş S, Cay HY. Electrochemical Behaviour of Sertraline Hydrochloride at a Glassy Carbon Electrode and Its Determination in Pharmaceutical Products Using Osteryoung Square Wave Voltammetry. Pharmazie. 2010;65(3):182-7. PubMed PMID: 20383937.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Electrochemical behaviour of sertraline hydrochloride at a glassy carbon electrode and its determination in pharmaceutical products using osteryoung square wave voltammetry. AU - Dermiş,S, AU - Cay,H Y, PY - 2010/4/14/entrez PY - 2010/4/14/pubmed PY - 2010/5/21/medline SP - 182 EP - 7 JF - Die Pharmazie JO - Pharmazie VL - 65 IS - 3 N2 - In this study the electrooxidation of sertraline (STR) hydrochloride in pH 8 Britton-Robinson buffer (BRb) -methanol (MeOH) (1:1,v/v) supporting electrolyte was investigated using Osteryoung Square Wave Voltammetry (OSWV) with the glassy carbon electrode. OSWV is a rapid and sensitive electro-analytical technique for sertraline determination. This study indicated that sertraline was susceptible to oxidation. The effects of the supporting electrolyte, pH and scan rate on the anodic reactions performed in BRb and a scan rate interval 5 - 1000 mVs(-1) were investigated. Sertraline hydrochloride was oxidized irreversibly and diffusion controlled. OSWV was selected for the quantitative determination. Using optimized OSWV technique, the current was linear within a concentration range of 0.04-0.8 mM in pH 8 BRb which at the equivalent volume with MeOH. The applicability of the proposed method was shown by the successful analysis of sertraline in tablet dosage forms. Accuracy, precision, selectivity, sensitivity, within day and between days reproducibility of the method were investigated statistically. Application of the suggested method to pharmaceutical formulation is presented and compared with the UV spectrophotometric and HPLC methods. The results were found to be in a good agreement. No interference was observed from common pharmaceutical adjuvants. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/20383937/Electrochemical_behaviour_of_sertraline_hydrochloride_at_a_glassy_carbon_electrode_and_its_determination_in_pharmaceutical_products_using_osteryoung_square_wave_voltammetry_ DB - PRIME DP - Unbound Medicine ER -