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Hepatocellular carcinoma in individuals with HBV infection or HBV-HCV co-infection in a low endemic country.
Scand J Gastroenterol. 2010 Aug; 45(7-8):944-52.SJ

Abstract

OBJECTIVE

The aim of this nationwide cohort study was to assess the risk for hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection or HBV and hepatitis C virus (HCV) co-infection in Sweden, a low endemic country.

MATERIAL AND METHODS

A total of 12,080 patients with HBV and 3238 patients with HBV-HCV co-infection were notified to the Swedish institute for Infectious Disease Control between 1990 and 2004. After excluding 1850 patients with acute HBV and 584 patients infected in adult life, we analyzed the cohort of 9646 subjects with chronic HBV infection. In the co-infection cohort, 1697 patients were analyzed after excluding 1541 cases with acute HBV. The Swedish national cancer registry was used for follow-up. The HCC incidence rate in the cohorts was compared with the HCC incidence rate in the general population and the standardized incidence ratio (SIR) was calculated for different strata according to estimated infection period.

RESULTS

HCC was found in 45 patients in the HBV cohort. In the stratum of 40-49 years of infection we found a SIR of 47 and in stratum 50-59 years the SIR was 54. In the co-infected cohort 10 HCCs were found. The SIR in the stratum 20-29 years of infection was 34 and the SIR in the stratum 30 years and over was 91.

CONCLUSIONS

This national cohort study of HBV infected and HBV-HCV co-infected subjects in a low endemic country confirms a highly increased risk of liver cancer compared to the general population.

Authors+Show Affiliations

Department of Gastroenterology and Hepatology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden. loa.davidsdottir@karolinska.seNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20384529

Citation

Davídsdóttir, Lóa, et al. "Hepatocellular Carcinoma in Individuals With HBV Infection or HBV-HCV Co-infection in a Low Endemic Country." Scandinavian Journal of Gastroenterology, vol. 45, no. 7-8, 2010, pp. 944-52.
Davídsdóttir L, Duberg AS, Törner A, et al. Hepatocellular carcinoma in individuals with HBV infection or HBV-HCV co-infection in a low endemic country. Scand J Gastroenterol. 2010;45(7-8):944-52.
Davídsdóttir, L., Duberg, A. S., Törner, A., Aleman, S., Bäck, E., Ekdahl, K., Blaxhult, A., Ekbom, A., & Hultcrantz, R. (2010). Hepatocellular carcinoma in individuals with HBV infection or HBV-HCV co-infection in a low endemic country. Scandinavian Journal of Gastroenterology, 45(7-8), 944-52. https://doi.org/10.3109/00365521003770251
Davídsdóttir L, et al. Hepatocellular Carcinoma in Individuals With HBV Infection or HBV-HCV Co-infection in a Low Endemic Country. Scand J Gastroenterol. 2010;45(7-8):944-52. PubMed PMID: 20384529.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hepatocellular carcinoma in individuals with HBV infection or HBV-HCV co-infection in a low endemic country. AU - Davídsdóttir,Lóa, AU - Duberg,Ann-Sofi, AU - Törner,Anna, AU - Aleman,Soo, AU - Bäck,Erik, AU - Ekdahl,Karl, AU - Blaxhult,Anders, AU - Ekbom,Anders, AU - Hultcrantz,Rolf, PY - 2010/4/14/entrez PY - 2010/4/14/pubmed PY - 2010/12/14/medline SP - 944 EP - 52 JF - Scandinavian journal of gastroenterology JO - Scand J Gastroenterol VL - 45 IS - 7-8 N2 - OBJECTIVE: The aim of this nationwide cohort study was to assess the risk for hepatocellular carcinoma (HCC) in patients with chronic hepatitis B virus (HBV) infection or HBV and hepatitis C virus (HCV) co-infection in Sweden, a low endemic country. MATERIAL AND METHODS: A total of 12,080 patients with HBV and 3238 patients with HBV-HCV co-infection were notified to the Swedish institute for Infectious Disease Control between 1990 and 2004. After excluding 1850 patients with acute HBV and 584 patients infected in adult life, we analyzed the cohort of 9646 subjects with chronic HBV infection. In the co-infection cohort, 1697 patients were analyzed after excluding 1541 cases with acute HBV. The Swedish national cancer registry was used for follow-up. The HCC incidence rate in the cohorts was compared with the HCC incidence rate in the general population and the standardized incidence ratio (SIR) was calculated for different strata according to estimated infection period. RESULTS: HCC was found in 45 patients in the HBV cohort. In the stratum of 40-49 years of infection we found a SIR of 47 and in stratum 50-59 years the SIR was 54. In the co-infected cohort 10 HCCs were found. The SIR in the stratum 20-29 years of infection was 34 and the SIR in the stratum 30 years and over was 91. CONCLUSIONS: This national cohort study of HBV infected and HBV-HCV co-infected subjects in a low endemic country confirms a highly increased risk of liver cancer compared to the general population. SN - 1502-7708 UR - https://www.unboundmedicine.com/medline/citation/20384529/Hepatocellular_carcinoma_in_individuals_with_HBV_infection_or_HBV_HCV_co_infection_in_a_low_endemic_country_ L2 - https://www.tandfonline.com/doi/full/10.3109/00365521003770251 DB - PRIME DP - Unbound Medicine ER -