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Dentinogenesis imperfecta in children with osteogenesis imperfecta: a clinical and ultrastructural study.
Int J Paediatr Dent. 2010 Mar; 20(2):112-8.IJ

Abstract

AIM

The aim of this study was to assess the correlation between osteogenesis imperfecta (OI) and dentinogenesis imperfecta (DI) from both a clinical and histological point of view, particularly clarifying the structural and ultrastructural dentine changes.

DESIGN

Sixteen children (6-12 years aged) with diagnosis of OI were examined for dental alterations referable to DI. For each patient, the OI type (I, III, or IV) was recorded. Extracted or normally exfoliated primary teeth were subjected to a histological examination (to both optical microscopy and confocal laser-scanning microscopy).

RESULTS

A total of ten patients had abnormal discolourations referable to DI: four patients were affected by OI type I, three patients by OI type III, and three patients by OI type IV. The discolourations, yellow/brown or opalescent grey, could not be related to the different types of OI. Histological exam of primary teeth showed severe pathological change in the dentin, structured into four different layers. A collagen defect due to odontoblast dysfunction was theorized to be on the base of the histological changes.

CONCLUSIONS

There is no correlation between the type of OI and the type of discolouration. The underlying dentinal defect seems to be related to an odontoblast dysfunction.

Authors+Show Affiliations

Department of Pediatric Dentistry, Dental School, University of Brescia, Brescia, Italy. majorana@med.unibs.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

20384825

Citation

Majorana, Alessandra, et al. "Dentinogenesis Imperfecta in Children With Osteogenesis Imperfecta: a Clinical and Ultrastructural Study." International Journal of Paediatric Dentistry, vol. 20, no. 2, 2010, pp. 112-8.
Majorana A, Bardellini E, Brunelli PC, et al. Dentinogenesis imperfecta in children with osteogenesis imperfecta: a clinical and ultrastructural study. Int J Paediatr Dent. 2010;20(2):112-8.
Majorana, A., Bardellini, E., Brunelli, P. C., Lacaita, M., Cazzolla, A. P., & Favia, G. (2010). Dentinogenesis imperfecta in children with osteogenesis imperfecta: a clinical and ultrastructural study. International Journal of Paediatric Dentistry, 20(2), 112-8. https://doi.org/10.1111/j.1365-263X.2010.01033.x
Majorana A, et al. Dentinogenesis Imperfecta in Children With Osteogenesis Imperfecta: a Clinical and Ultrastructural Study. Int J Paediatr Dent. 2010;20(2):112-8. PubMed PMID: 20384825.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dentinogenesis imperfecta in children with osteogenesis imperfecta: a clinical and ultrastructural study. AU - Majorana,Alessandra, AU - Bardellini,Elena, AU - Brunelli,Pier Carlo, AU - Lacaita,Mariagrazia, AU - Cazzolla,Angela Pia, AU - Favia,Gianfranco, PY - 2010/4/14/entrez PY - 2010/4/14/pubmed PY - 2010/7/7/medline SP - 112 EP - 8 JF - International journal of paediatric dentistry JO - Int J Paediatr Dent VL - 20 IS - 2 N2 - AIM: The aim of this study was to assess the correlation between osteogenesis imperfecta (OI) and dentinogenesis imperfecta (DI) from both a clinical and histological point of view, particularly clarifying the structural and ultrastructural dentine changes. DESIGN: Sixteen children (6-12 years aged) with diagnosis of OI were examined for dental alterations referable to DI. For each patient, the OI type (I, III, or IV) was recorded. Extracted or normally exfoliated primary teeth were subjected to a histological examination (to both optical microscopy and confocal laser-scanning microscopy). RESULTS: A total of ten patients had abnormal discolourations referable to DI: four patients were affected by OI type I, three patients by OI type III, and three patients by OI type IV. The discolourations, yellow/brown or opalescent grey, could not be related to the different types of OI. Histological exam of primary teeth showed severe pathological change in the dentin, structured into four different layers. A collagen defect due to odontoblast dysfunction was theorized to be on the base of the histological changes. CONCLUSIONS: There is no correlation between the type of OI and the type of discolouration. The underlying dentinal defect seems to be related to an odontoblast dysfunction. SN - 1365-263X UR - https://www.unboundmedicine.com/medline/citation/20384825/Dentinogenesis_imperfecta_in_children_with_osteogenesis_imperfecta:_a_clinical_and_ultrastructural_study_ L2 - https://doi.org/10.1111/j.1365-263X.2010.01033.x DB - PRIME DP - Unbound Medicine ER -