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Overnight urinary excretion of isoflavones as an indicator for dietary isoflavone intake in Korean girls of pubertal age.
Br J Nutr. 2010 Sep; 104(5):709-15.BJ

Abstract

Little is known about the bioavailability of isoflavones in children. Previous studies have shown that children excrete more isoflavone in urine compared with adults. Thus we examined the relationship between usual dietary isoflavone intake and the urinary excretion of isoflavonoids in Korean girls of pubertal age. Twelve girls each were selected from the lowest and the highest quartiles of isoflavone intake among 252 Korean girls aged 8-11 years. Age, BMI and sexual maturation stage were matched between the two groups. Dietary intakes for 3 d by diet record and overnight urine samples were collected at baseline and at 6 and 12 months. Total and individual isoflavone (daidzein, genistein and glycitein) intakes were calculated from diet records. The parent isoflavone compounds (daidzein, genistein and glycitein) and their metabolites (equol, O-desmethylangolensin (O-DMA), dihydrodaidzein and dihydrogenistein) present in the urine samples were analysed using liquid chromatography-MS. Intake levels of total and individual isoflavone compounds were significantly higher in the high isoflavone (HI) group than the levels in the low isoflavone (LI) group (P < 0.05). Urinary excretion of all isoflavone parent compounds was significantly higher in the HI group than in the LI group (P < 0.0001). Among isoflavone metabolites, only O-DMA and total metabolites were significantly different (P < 0.05). Total isoflavone intake was highly correlated with the urinary excretion of total parent compounds (r 0.68; P < 0.01), parent compounds plus their metabolites (r 0.66-0.69; P < 0.01) and total isoflavonoids (r 0.72; P < 0.0001). In conclusion, overnight urinary excretion of total isoflavonoids is a reliable biomarker of usual isoflavone intake in Korean girls of pubertal age.

Authors+Show Affiliations

Department of Food and Nutrition, Daegu University, Gyeongbuk 712-714, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20385037

Citation

Kim, Jihye, et al. "Overnight Urinary Excretion of Isoflavones as an Indicator for Dietary Isoflavone Intake in Korean Girls of Pubertal Age." The British Journal of Nutrition, vol. 104, no. 5, 2010, pp. 709-15.
Kim J, Kim HJ, Joung H, et al. Overnight urinary excretion of isoflavones as an indicator for dietary isoflavone intake in Korean girls of pubertal age. Br J Nutr. 2010;104(5):709-15.
Kim, J., Kim, H. J., Joung, H., Park, M. K., Li, S., Song, Y., Franke, A. A., & Paik, H. Y. (2010). Overnight urinary excretion of isoflavones as an indicator for dietary isoflavone intake in Korean girls of pubertal age. The British Journal of Nutrition, 104(5), 709-15. https://doi.org/10.1017/S0007114510000978
Kim J, et al. Overnight Urinary Excretion of Isoflavones as an Indicator for Dietary Isoflavone Intake in Korean Girls of Pubertal Age. Br J Nutr. 2010;104(5):709-15. PubMed PMID: 20385037.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Overnight urinary excretion of isoflavones as an indicator for dietary isoflavone intake in Korean girls of pubertal age. AU - Kim,Jihye, AU - Kim,Hye Jin, AU - Joung,Hyojee, AU - Park,Min Kyung, AU - Li,Shanji, AU - Song,YoonJu, AU - Franke,Adrian A, AU - Paik,Hee-Young, Y1 - 2010/04/13/ PY - 2010/4/14/entrez PY - 2010/4/14/pubmed PY - 2010/9/24/medline SP - 709 EP - 15 JF - The British journal of nutrition JO - Br. J. Nutr. VL - 104 IS - 5 N2 - Little is known about the bioavailability of isoflavones in children. Previous studies have shown that children excrete more isoflavone in urine compared with adults. Thus we examined the relationship between usual dietary isoflavone intake and the urinary excretion of isoflavonoids in Korean girls of pubertal age. Twelve girls each were selected from the lowest and the highest quartiles of isoflavone intake among 252 Korean girls aged 8-11 years. Age, BMI and sexual maturation stage were matched between the two groups. Dietary intakes for 3 d by diet record and overnight urine samples were collected at baseline and at 6 and 12 months. Total and individual isoflavone (daidzein, genistein and glycitein) intakes were calculated from diet records. The parent isoflavone compounds (daidzein, genistein and glycitein) and their metabolites (equol, O-desmethylangolensin (O-DMA), dihydrodaidzein and dihydrogenistein) present in the urine samples were analysed using liquid chromatography-MS. Intake levels of total and individual isoflavone compounds were significantly higher in the high isoflavone (HI) group than the levels in the low isoflavone (LI) group (P < 0.05). Urinary excretion of all isoflavone parent compounds was significantly higher in the HI group than in the LI group (P < 0.0001). Among isoflavone metabolites, only O-DMA and total metabolites were significantly different (P < 0.05). Total isoflavone intake was highly correlated with the urinary excretion of total parent compounds (r 0.68; P < 0.01), parent compounds plus their metabolites (r 0.66-0.69; P < 0.01) and total isoflavonoids (r 0.72; P < 0.0001). In conclusion, overnight urinary excretion of total isoflavonoids is a reliable biomarker of usual isoflavone intake in Korean girls of pubertal age. SN - 1475-2662 UR - https://www.unboundmedicine.com/medline/citation/20385037/Overnight_urinary_excretion_of_isoflavones_as_an_indicator_for_dietary_isoflavone_intake_in_Korean_girls_of_pubertal_age_ L2 - https://www.cambridge.org/core/product/identifier/S0007114510000978/type/journal_article DB - PRIME DP - Unbound Medicine ER -