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Dietary glycemic load and index and risk of coronary heart disease in a large italian cohort: the EPICOR study.
Arch Intern Med 2010; 170(7):640-7AI

Abstract

BACKGROUND

Dietary glycemic load (GL) and glycemic index (GI) in relation to cardiovascular disease have been investigated in a few prospective studies with inconsistent results, particularly in men. The present EPICOR study investigated the association of GI and GL with coronary heart disease (CHD) in a large and heterogeneous cohort of Italian men and women originally recruited to the European Prospective Investigation into Cancer and Nutrition study.

METHODS

We studied 47 749 volunteers (15 171 men and 32 578 women) who completed a dietary questionnaire. Multivariate Cox proportional hazards modeling estimated adjusted relative risks (RRs) of CHD and 95% confidence intervals (CIs).

RESULTS

During a median of 7.9 years of follow-up, 463 CHD cases (158 women and 305 men) were identified. Women in the highest carbohydrate intake quartile had a significantly greater risk of CHD than did those in the lowest quartile (RR, 2.00; 95% CI, 1.16-3.43), with no association found in men (P = .04 for interaction). Increasing carbohydrate intake from high-GI foods was also significantly associated with greater risk of CHD in women (RR, 1.68; 95% CI, 1.02-2.75), whereas increasing the intake of low-GI carbohydrates was not. Women in the highest GL quartile had a significantly greater risk of CHD than did those in the lowest quartile (RR, 2.24; 95% CI, 1.26-3.98), with no significant association in men (P = .03 for interaction).

CONCLUSION

In this Italian cohort, high dietary GL and carbohydrate intake from high-GI foods increase the overall risk of CHD in women but not men.

Authors+Show Affiliations

Nutritional Epidemiology Unit, Fondazione IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) Istituto Nazionale Tumori, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20386010

Citation

Sieri, Sabina, et al. "Dietary Glycemic Load and Index and Risk of Coronary Heart Disease in a Large Italian Cohort: the EPICOR Study." Archives of Internal Medicine, vol. 170, no. 7, 2010, pp. 640-7.
Sieri S, Krogh V, Berrino F, et al. Dietary glycemic load and index and risk of coronary heart disease in a large italian cohort: the EPICOR study. Arch Intern Med. 2010;170(7):640-7.
Sieri, S., Krogh, V., Berrino, F., Evangelista, A., Agnoli, C., Brighenti, F., ... Panico, S. (2010). Dietary glycemic load and index and risk of coronary heart disease in a large italian cohort: the EPICOR study. Archives of Internal Medicine, 170(7), pp. 640-7. doi:10.1001/archinternmed.2010.15.
Sieri S, et al. Dietary Glycemic Load and Index and Risk of Coronary Heart Disease in a Large Italian Cohort: the EPICOR Study. Arch Intern Med. 2010 Apr 12;170(7):640-7. PubMed PMID: 20386010.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary glycemic load and index and risk of coronary heart disease in a large italian cohort: the EPICOR study. AU - Sieri,Sabina, AU - Krogh,Vittorio, AU - Berrino,Franco, AU - Evangelista,Alberto, AU - Agnoli,Claudia, AU - Brighenti,Furio, AU - Pellegrini,Nicoletta, AU - Palli,Domenico, AU - Masala,Giovanna, AU - Sacerdote,Carlotta, AU - Veglia,Fabrizio, AU - Tumino,Rosario, AU - Frasca,Graziella, AU - Grioni,Sara, AU - Pala,Valeria, AU - Mattiello,Amalia, AU - Chiodini,Paolo, AU - Panico,Salvatore, PY - 2010/4/14/entrez PY - 2010/4/14/pubmed PY - 2010/5/4/medline SP - 640 EP - 7 JF - Archives of internal medicine JO - Arch. Intern. Med. VL - 170 IS - 7 N2 - BACKGROUND: Dietary glycemic load (GL) and glycemic index (GI) in relation to cardiovascular disease have been investigated in a few prospective studies with inconsistent results, particularly in men. The present EPICOR study investigated the association of GI and GL with coronary heart disease (CHD) in a large and heterogeneous cohort of Italian men and women originally recruited to the European Prospective Investigation into Cancer and Nutrition study. METHODS: We studied 47 749 volunteers (15 171 men and 32 578 women) who completed a dietary questionnaire. Multivariate Cox proportional hazards modeling estimated adjusted relative risks (RRs) of CHD and 95% confidence intervals (CIs). RESULTS: During a median of 7.9 years of follow-up, 463 CHD cases (158 women and 305 men) were identified. Women in the highest carbohydrate intake quartile had a significantly greater risk of CHD than did those in the lowest quartile (RR, 2.00; 95% CI, 1.16-3.43), with no association found in men (P = .04 for interaction). Increasing carbohydrate intake from high-GI foods was also significantly associated with greater risk of CHD in women (RR, 1.68; 95% CI, 1.02-2.75), whereas increasing the intake of low-GI carbohydrates was not. Women in the highest GL quartile had a significantly greater risk of CHD than did those in the lowest quartile (RR, 2.24; 95% CI, 1.26-3.98), with no significant association in men (P = .03 for interaction). CONCLUSION: In this Italian cohort, high dietary GL and carbohydrate intake from high-GI foods increase the overall risk of CHD in women but not men. SN - 1538-3679 UR - https://www.unboundmedicine.com/medline/citation/20386010/Dietary_glycemic_load_and_index_and_risk_of_coronary_heart_disease_in_a_large_italian_cohort:_the_EPICOR_study_ L2 - https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/10.1001/archinternmed.2010.15 DB - PRIME DP - Unbound Medicine ER -