Tags

Type your tag names separated by a space and hit enter

Predicting the magnitude of short-term CD4+ T-cell recovery in HIV-infected patients during first-line highly active antiretroviral therapy.
Antivir Ther. 2010; 15(2):165-75.AT

Abstract

BACKGROUND

The extent of short-term CD4(+) T-cell recovery in patients tolerating first-line highly active antiretroviral therapy (HAART) and attaining undetectable HIV RNA levels is inadequately defined.

METHODS

We retrospectively analysed patients in four Italian cohorts who started HAART between January 1996 and September 2006. All patients had known HCV coinfection status, did not modify the regimen for 6 months and had <50 HIV RNA copies/ml at the end of the sixth month.

RESULTS

The analysis involved 1,488 patients (1,096 males, 73.7%) with a median age of 43 years (interquartile range [IQR] 39-49); 435 (29.2%) were positive for HCV, 71 (4.8%) were positive for hepatitis B surface antigen (HBsAg) and 76 (5.1%) had experienced a previous AIDS-defining event. At baseline, patient CD4(+) T-cell counts were 226 cells/microl (IQR 99-332), CD4(+) T-cell percentages were 14.7% (IQR 8.7-21.2) and HIV RNA levels were 4.91 log(10) copies/ml (IQR 4.38-5.34). Overall, 24-week CD4(+) T-cell recovery was 144 cells/microl (IQR 70-240). At multivariable analysis, T-cell recovery was positively related to the use of a boosted protease inhibitor (P<0.0001) or thymidine analogues (P<0.0001), baseline HIV RNA levels (P<0.0001), the baseline percentage of CD4(+) T-cells (P<0.0001) and the absence of HCV coinfection (P=0.006). Age, gender, baseline CD4(+)/CD8(+) T-cell ratio and a history of AIDS-defining events had no independent effect on CD4(+) T-cell recovery.

CONCLUSIONS

Among HIV-infected patients tolerating first-line HAART and with undetectable HIV RNA after 6 months, CD4(+) T-cell recovery is significantly greater in those without HCV coinfection, with a high baseline viral load, a high baseline percentage of CD4(+) T-cells and in those treated with a boosted protease inhibitor.

Authors+Show Affiliations

Infectious Diseases Department, San Raffaele Scientific Institute, Milan, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Multicenter Study

Language

eng

PubMed ID

20386071

Citation

Castagna, Antonella, et al. "Predicting the Magnitude of Short-term CD4+ T-cell Recovery in HIV-infected Patients During First-line Highly Active Antiretroviral Therapy." Antiviral Therapy, vol. 15, no. 2, 2010, pp. 165-75.
Castagna A, Galli L, Torti C, et al. Predicting the magnitude of short-term CD4+ T-cell recovery in HIV-infected patients during first-line highly active antiretroviral therapy. Antivir Ther. 2010;15(2):165-75.
Castagna, A., Galli, L., Torti, C., D'Arminio Monforte, A., Mussini, C., Antinori, A., Cozzi-Lepri, A., Ladisa, N., De Luca, A., Seminari, E., Gianotti, N., & Lazzarin, A. (2010). Predicting the magnitude of short-term CD4+ T-cell recovery in HIV-infected patients during first-line highly active antiretroviral therapy. Antiviral Therapy, 15(2), 165-75. https://doi.org/10.3851/IMP1513
Castagna A, et al. Predicting the Magnitude of Short-term CD4+ T-cell Recovery in HIV-infected Patients During First-line Highly Active Antiretroviral Therapy. Antivir Ther. 2010;15(2):165-75. PubMed PMID: 20386071.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Predicting the magnitude of short-term CD4+ T-cell recovery in HIV-infected patients during first-line highly active antiretroviral therapy. AU - Castagna,Antonella, AU - Galli,Laura, AU - Torti,Carlo, AU - D'Arminio Monforte,Antonella, AU - Mussini,Cristina, AU - Antinori,Andrea, AU - Cozzi-Lepri,Alessandro, AU - Ladisa,Nicoletta, AU - De Luca,Andrea, AU - Seminari,Elena, AU - Gianotti,Nicola, AU - Lazzarin,Adriano, PY - 2010/4/14/entrez PY - 2010/4/14/pubmed PY - 2010/7/20/medline SP - 165 EP - 75 JF - Antiviral therapy JO - Antivir Ther VL - 15 IS - 2 N2 - BACKGROUND: The extent of short-term CD4(+) T-cell recovery in patients tolerating first-line highly active antiretroviral therapy (HAART) and attaining undetectable HIV RNA levels is inadequately defined. METHODS: We retrospectively analysed patients in four Italian cohorts who started HAART between January 1996 and September 2006. All patients had known HCV coinfection status, did not modify the regimen for 6 months and had <50 HIV RNA copies/ml at the end of the sixth month. RESULTS: The analysis involved 1,488 patients (1,096 males, 73.7%) with a median age of 43 years (interquartile range [IQR] 39-49); 435 (29.2%) were positive for HCV, 71 (4.8%) were positive for hepatitis B surface antigen (HBsAg) and 76 (5.1%) had experienced a previous AIDS-defining event. At baseline, patient CD4(+) T-cell counts were 226 cells/microl (IQR 99-332), CD4(+) T-cell percentages were 14.7% (IQR 8.7-21.2) and HIV RNA levels were 4.91 log(10) copies/ml (IQR 4.38-5.34). Overall, 24-week CD4(+) T-cell recovery was 144 cells/microl (IQR 70-240). At multivariable analysis, T-cell recovery was positively related to the use of a boosted protease inhibitor (P<0.0001) or thymidine analogues (P<0.0001), baseline HIV RNA levels (P<0.0001), the baseline percentage of CD4(+) T-cells (P<0.0001) and the absence of HCV coinfection (P=0.006). Age, gender, baseline CD4(+)/CD8(+) T-cell ratio and a history of AIDS-defining events had no independent effect on CD4(+) T-cell recovery. CONCLUSIONS: Among HIV-infected patients tolerating first-line HAART and with undetectable HIV RNA after 6 months, CD4(+) T-cell recovery is significantly greater in those without HCV coinfection, with a high baseline viral load, a high baseline percentage of CD4(+) T-cells and in those treated with a boosted protease inhibitor. SN - 2040-2058 UR - https://www.unboundmedicine.com/medline/citation/20386071/Predicting_the_magnitude_of_short_term_CD4+_T_cell_recovery_in_HIV_infected_patients_during_first_line_highly_active_antiretroviral_therapy_ L2 - http://www.diseaseinfosearch.org/result/9735 DB - PRIME DP - Unbound Medicine ER -