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Prevention of parenteral nutrition-associated liver disease: lipid minimization.
Curr Opin Organ Transplant. 2010 Jun; 15(3):330-3.CO

Abstract

PURPOSE OF REVIEW

The cause of parenteral nutrition-associated liver disease (PNALD) is unknown. Evidence over the past decade has suggested soybean oil-based intravenous emulsions are a contributing factor to the development of PNALD.

RECENT FINDINGS

This review details the historical and scientific rationale, which associates intravenous lipid emulsion administration and PNALD. The article then reviews our own group's experience with lipid restriction and the reversal of PNALD in neonates on long-term parenteral nutrition. Finally, a clinical approach to restricting soybean-based intravenous lipid emulsions in parenteral nutrition is given.

SUMMARY

An association between intravenous lipid emulsion administration and the development of PNALD seems probable. Strategies to reduce lipid emulsions or develop new, nonsoybean-based lipid emulsions should be considered.

Authors+Show Affiliations

Department of Pharmacy, University of Michigan Hospitals and Health Centers, and CS Mott Children's Hospital, Ann Arbor, Michigan, USA. mcober@umich.eduNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

20386446

Citation

Cober, M Petrea, and Daniel H. Teitelbaum. "Prevention of Parenteral Nutrition-associated Liver Disease: Lipid Minimization." Current Opinion in Organ Transplantation, vol. 15, no. 3, 2010, pp. 330-3.
Cober MP, Teitelbaum DH. Prevention of parenteral nutrition-associated liver disease: lipid minimization. Curr Opin Organ Transplant. 2010;15(3):330-3.
Cober, M. P., & Teitelbaum, D. H. (2010). Prevention of parenteral nutrition-associated liver disease: lipid minimization. Current Opinion in Organ Transplantation, 15(3), 330-3. https://doi.org/10.1097/MOT.0b013e328338c2da
Cober MP, Teitelbaum DH. Prevention of Parenteral Nutrition-associated Liver Disease: Lipid Minimization. Curr Opin Organ Transplant. 2010;15(3):330-3. PubMed PMID: 20386446.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Prevention of parenteral nutrition-associated liver disease: lipid minimization. AU - Cober,M Petrea, AU - Teitelbaum,Daniel H, PY - 2010/4/14/entrez PY - 2010/4/14/pubmed PY - 2010/8/31/medline SP - 330 EP - 3 JF - Current opinion in organ transplantation JO - Curr Opin Organ Transplant VL - 15 IS - 3 N2 - PURPOSE OF REVIEW: The cause of parenteral nutrition-associated liver disease (PNALD) is unknown. Evidence over the past decade has suggested soybean oil-based intravenous emulsions are a contributing factor to the development of PNALD. RECENT FINDINGS: This review details the historical and scientific rationale, which associates intravenous lipid emulsion administration and PNALD. The article then reviews our own group's experience with lipid restriction and the reversal of PNALD in neonates on long-term parenteral nutrition. Finally, a clinical approach to restricting soybean-based intravenous lipid emulsions in parenteral nutrition is given. SUMMARY: An association between intravenous lipid emulsion administration and the development of PNALD seems probable. Strategies to reduce lipid emulsions or develop new, nonsoybean-based lipid emulsions should be considered. SN - 1531-7013 UR - https://www.unboundmedicine.com/medline/citation/20386446/Prevention_of_parenteral_nutrition_associated_liver_disease:_lipid_minimization_ L2 - https://doi.org/10.1097/MOT.0b013e328338c2da DB - PRIME DP - Unbound Medicine ER -