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Correlation between an interleukin-6 -572C/G polymorphism and chronic periodontitis.
Int J Periodontics Restorative Dent. 2010 Jun; 30(3):301-5.IJ

Abstract

Genetic polymorphisms in the interleukin-6 (IL-6) gene are associated with bone homeostasis and diseases characterized by bone loss. The aim of this study was to investigate the correlation between the IL-6-572C/G polymorphism and the risk of chronic periodontitis in a Chinese Han population. The IL-6-572C/G polymorphism was genotyped in 93 patients suffering from chronic periodontitis and 96 control subjects by polymerase chain reaction-restriction fragment length polymorphism. DNA was extracted from the peripheral blood of patients and control subjects and amplified using a polymerase chain reaction. IL-6 genotypes were identified using gel electrophoresis. The IL-6-572 GG genotype and the G allele were more frequent in chronic periodontitis patients than in control subjects (P<.05). When compared with the CC genotype, the odds ratio for chronic periodontitis was 1.88 (95% confidence interval, 1.04 to 3.40; P<.05) for the CG+GG genotype. The frequency of the -572CG+GG genotype was significantly different between the control group and the group with chronic periodontitis. Therefore, the IL-6-572C/G polymorphism may contribute to the susceptibility to chronic periodontitis in the Chinese Han population.

Authors+Show Affiliations

Dental College, Zhengzhou University, and Department of Stomatology, Henan Provincial People's Hospital, Henan, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20386787

Citation

Jingjin, Liu, et al. "Correlation Between an Interleukin-6 -572C/G Polymorphism and Chronic Periodontitis." The International Journal of Periodontics & Restorative Dentistry, vol. 30, no. 3, 2010, pp. 301-5.
Jingjin L, Zemin G, Xin M, et al. Correlation between an interleukin-6 -572C/G polymorphism and chronic periodontitis. Int J Periodontics Restorative Dent. 2010;30(3):301-5.
Jingjin, L., Zemin, G., Xin, M., Donghong, W., Jianhua, G., Jie, Y., & Yonggong, W. (2010). Correlation between an interleukin-6 -572C/G polymorphism and chronic periodontitis. The International Journal of Periodontics & Restorative Dentistry, 30(3), 301-5.
Jingjin L, et al. Correlation Between an Interleukin-6 -572C/G Polymorphism and Chronic Periodontitis. Int J Periodontics Restorative Dent. 2010;30(3):301-5. PubMed PMID: 20386787.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Correlation between an interleukin-6 -572C/G polymorphism and chronic periodontitis. AU - Jingjin,Liu, AU - Zemin,Guan, AU - Xin,Ma, AU - Donghong,Wu, AU - Jianhua,Geng, AU - Jie,Yi, AU - Yonggong,Wang, PY - 2010/4/14/entrez PY - 2010/4/14/pubmed PY - 2010/8/31/medline SP - 301 EP - 5 JF - The International journal of periodontics & restorative dentistry JO - Int J Periodontics Restorative Dent VL - 30 IS - 3 N2 - Genetic polymorphisms in the interleukin-6 (IL-6) gene are associated with bone homeostasis and diseases characterized by bone loss. The aim of this study was to investigate the correlation between the IL-6-572C/G polymorphism and the risk of chronic periodontitis in a Chinese Han population. The IL-6-572C/G polymorphism was genotyped in 93 patients suffering from chronic periodontitis and 96 control subjects by polymerase chain reaction-restriction fragment length polymorphism. DNA was extracted from the peripheral blood of patients and control subjects and amplified using a polymerase chain reaction. IL-6 genotypes were identified using gel electrophoresis. The IL-6-572 GG genotype and the G allele were more frequent in chronic periodontitis patients than in control subjects (P<.05). When compared with the CC genotype, the odds ratio for chronic periodontitis was 1.88 (95% confidence interval, 1.04 to 3.40; P<.05) for the CG+GG genotype. The frequency of the -572CG+GG genotype was significantly different between the control group and the group with chronic periodontitis. Therefore, the IL-6-572C/G polymorphism may contribute to the susceptibility to chronic periodontitis in the Chinese Han population. SN - 0198-7569 UR - https://www.unboundmedicine.com/medline/citation/20386787/Correlation_between_an_interleukin_6__572C/G_polymorphism_and_chronic_periodontitis_ L2 - https://antibodies.cancer.gov/detail/CPTC-IL6-1 DB - PRIME DP - Unbound Medicine ER -