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Mechanical modeling of red blood cells during optical stretching.
J Biomech Eng 2010; 132(4):044504JB

Abstract

Mechanical properties of red blood cells (RBCs) play an important role in regulating cellular functions. Many recent researches suggest that the cell properties or deformability may be used as a diagnostic indicator for the onset and progression of some human diseases. Although optical stretcher (OS) has emerged as an effective tool to investigate the cell mechanics of RBCs, little is known about the deformation behavior of RBCs in an OS. To address this problem, the mechanical model proposed in our previous work is extended in this paper to describe the mechanical responses of RBCs in the OS. With this model, the mechanical responses, such as the tension distribution, the effect of cell radius, and the deformed cell shapes, can be predicted. It is shown that the results obtained from our mechanical model are in good agreement with the experimental data, which demonstrates the validity of the developed model. Based on the derived model, the mechanical properties of RBCs can be further obtained. In conclusion, this study indicates that the developed mechanical model can be used to predict the deformation responses of RBCs during optical stretching and has potential biomedical applications such as characterizing cell properties and distinguishing abnormal cells from normal ones.

Authors+Show Affiliations

Control and Mechatronics Group, Joint Advanced Research Center of City University of Hong Kong and University of Science and Technology of China, Suzhou 215123, China. youhuatan2@student.cityu.edu.hkNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

20387977

Citation

Tan, Youhua, et al. "Mechanical Modeling of Red Blood Cells During Optical Stretching." Journal of Biomechanical Engineering, vol. 132, no. 4, 2010, p. 044504.
Tan Y, Sun D, Huang W. Mechanical modeling of red blood cells during optical stretching. J Biomech Eng. 2010;132(4):044504.
Tan, Y., Sun, D., & Huang, W. (2010). Mechanical modeling of red blood cells during optical stretching. Journal of Biomechanical Engineering, 132(4), p. 044504. doi:10.1115/1.4001042.
Tan Y, Sun D, Huang W. Mechanical Modeling of Red Blood Cells During Optical Stretching. J Biomech Eng. 2010;132(4):044504. PubMed PMID: 20387977.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Mechanical modeling of red blood cells during optical stretching. AU - Tan,Youhua, AU - Sun,Dong, AU - Huang,Wenhao, PY - 2010/4/15/entrez PY - 2010/4/15/pubmed PY - 2010/7/22/medline SP - 044504 EP - 044504 JF - Journal of biomechanical engineering JO - J Biomech Eng VL - 132 IS - 4 N2 - Mechanical properties of red blood cells (RBCs) play an important role in regulating cellular functions. Many recent researches suggest that the cell properties or deformability may be used as a diagnostic indicator for the onset and progression of some human diseases. Although optical stretcher (OS) has emerged as an effective tool to investigate the cell mechanics of RBCs, little is known about the deformation behavior of RBCs in an OS. To address this problem, the mechanical model proposed in our previous work is extended in this paper to describe the mechanical responses of RBCs in the OS. With this model, the mechanical responses, such as the tension distribution, the effect of cell radius, and the deformed cell shapes, can be predicted. It is shown that the results obtained from our mechanical model are in good agreement with the experimental data, which demonstrates the validity of the developed model. Based on the derived model, the mechanical properties of RBCs can be further obtained. In conclusion, this study indicates that the developed mechanical model can be used to predict the deformation responses of RBCs during optical stretching and has potential biomedical applications such as characterizing cell properties and distinguishing abnormal cells from normal ones. SN - 1528-8951 UR - https://www.unboundmedicine.com/medline/citation/20387977/Mechanical_modeling_of_red_blood_cells_during_optical_stretching_ L2 - http://biomechanical.asmedigitalcollection.asme.org/article.aspx?doi=10.1115/1.4001042 DB - PRIME DP - Unbound Medicine ER -